In vitro time–kill analysis of oritavancin against clinical isolates of methicillin-resistant Staphylococcus aureus with reduced susceptibility to daptomycin

ABSTRACT This study employs time-kill techniques to examine the most common drug combinations used in the therapy of methicillin-resistant Staphylococcus aureus (MRSA) infections, vancomycin plus either gentamicin or rifampin. Community-associated MRSA were more likely to be synergistically inhibited by combinations of vancomycin and gentamicin versus vancomycin alone compared to inhibition associated with hospital-acquired strains.

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In vitro activity of minocycline combined with fosfomycin against clinical isolates of methicillin-resistant Staphylococcus aureus

The Journal of Antibiotics ◽

10.1038/ja.2011.52 ◽

2011 ◽

Vol 64 (8) ◽

pp. 559-562 ◽

Cited By ~ 3

Author(s):

Chunguang Sun ◽

Matthew E Falagas ◽

Rui Wang ◽

Drosos E Karageorgopoulos ◽

Xuhong Yu ◽

...

Keyword(s):

Staphylococcus Aureus ◽

Methicillin Resistant Staphylococcus Aureus ◽

Vitro Activity ◽

Clinical Isolates ◽

In Vitro Activity ◽

Methicillin Resistant

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In vitro synergism of magnolol and honokiol in combination with antibacterial agents against clinical isolates of methicillin-resistant Staphylococcus aureus (MRSA)

BMC Complementary and Alternative Medicine ◽

10.1186/s12906-015-0938-3 ◽

2015 ◽

Vol 15 (1) ◽

Cited By ~ 9

Author(s):

Guo-Ying Zuo ◽

Xin-Juan Zhang ◽

Jun Han ◽

Yu-Qing Li ◽

Gen-Chun Wang

Keyword(s):

Staphylococcus Aureus ◽

Antibacterial Agents ◽

Methicillin Resistant Staphylococcus Aureus ◽

Clinical Isolates ◽

Methicillin Resistant

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ComparativeIn VitroActivities of Oritavancin, Dalbavancin, and Vancomycin against Methicillin-Resistant Staphylococcus aureus Isolates in a Nondividing State

Antimicrobial Agents and Chemotherapy ◽

10.1128/aac.00169-16 ◽

2016 ◽

Vol 60 (7) ◽

pp. 4342-4345 ◽

Cited By ~ 8

Author(s):

Adam Belley ◽

David Lalonde Seguin ◽

Francis Arhin ◽

Greg Moeck

Keyword(s):

Staphylococcus Aureus ◽

Bactericidal Activity ◽

Antibacterial Agents ◽

Methicillin Resistant Staphylococcus Aureus ◽

Methicillin Resistant ◽

Content Type ◽

Skin Structure ◽

Persistent Infections ◽

Time Kill

ABSTRACTAntibacterial agents that kill nondividing bacteria may be of utility in treating persistent infections. Oritavancin and dalbavancin are bactericidal lipoglycopeptides that are approved for acute bacterial skin and skin structure infections in adults caused by susceptible Gram-positive pathogens. Using time-kill methodology, we demonstrate that oritavancin exerts bactericidal activity against methicillin-resistantStaphylococcus aureus(MRSA) isolates that are maintained in a nondividing statein vitro, whereas dalbavancin and the glycopeptide vancomycin do not.

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In Vitro 24-Hour Time-Kill Studies of Vancomycin and Linezolid in Combination versus Methicillin-Resistant Staphylococcus aureus

Antimicrobial Agents and Chemotherapy ◽

10.1128/aac.00237-09 ◽

2009 ◽

Vol 53 (10) ◽

pp. 4495-4497 ◽

Cited By ~ 35

Author(s):

Shveta Rani Singh ◽

Alfred E. Bacon ◽

David C. Young ◽

Kimberly A. Couch

Keyword(s):

Staphylococcus Aureus ◽

Conventional Therapy ◽

Methicillin Resistant Staphylococcus Aureus ◽

Antagonistic Activity ◽

Vitro Activity ◽

Synergistic Activity ◽

In Vitro Activity ◽

Methicillin Resistant ◽

Time Kill

ABSTRACT Many clinicians are trying unique strategies, including vancomycin and linezolid in combination, for treatment of patients who do not respond to conventional therapy against methicillin (meticillin)-resistant Staphylococcus aureus. In our study, which illustrated in vitro activity only, no synergistic activity was seen when the two agents were combined. Conversely, antagonistic activity occurred in three of five strains when linezolid was added to vancomycin. Our results indicate that vancomycin and linezolid in combination should be avoided.

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EFFICACY OF SHORT COURSES OF ORAL NOVOBIOCIN-RIFAMPIN IN ERADICATING CARRIER STATE OF METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS AND IN VITRO KILLING STUDIES OF CLINICAL ISOLATES

The Pediatric Infectious Disease Journal ◽

10.1097/00006454-199103000-00029 ◽

1991 ◽

Vol 10 (3) ◽

pp. 261

Author(s):

&NA;

Keyword(s):

Staphylococcus Aureus ◽

Methicillin Resistant Staphylococcus Aureus ◽

Carrier State ◽

Clinical Isolates ◽

Methicillin Resistant ◽

Short Courses

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Efficacy of Telavancin in a Rabbit Model of Aortic Valve Endocarditis Due to Methicillin-Resistant Staphylococcus aureus or Vancomycin-Intermediate Staphylococcus aureus

Antimicrobial Agents and Chemotherapy ◽

10.1128/aac.49.8.3163-3165.2005 ◽

2005 ◽

Vol 49 (8) ◽

pp. 3163-3165 ◽

Cited By ~ 59

Author(s):

Andres G. Madrigal ◽

Li Basuino ◽

Henry F. Chambers

Keyword(s):

Staphylococcus Aureus ◽

Aortic Valve ◽

Methicillin Resistant Staphylococcus Aureus ◽

No Reduction ◽

Rabbit Model ◽

Daily Regimen ◽

Methicillin Resistant ◽

Days Of Therapy ◽

Time Kill

ABSTRACT The activities of telavancin and vancomycin were compared in vitro and in the rabbit model of aortic valve endocarditis against a methicillin-resistant Staphylococcus aureus strain, COL, and a vancomycin-intermediate S. aureus (VISA) strain, HIP 5836. Telavancin was bactericidal in time-kill studies at a concentration of 5 μg/ml against both COL and HIP5836. Vancomycin was bacteriostatic at 5 μg/ml and bactericidal at 10 μg/ml against COL and was bacteriostatic at 10 μg/ml against VISA strain HIP 5836. Compared to untreated controls, a twice-daily regimen of 30 mg/kg of telavancin reduced mean aortic valve vegetation titers of the COL strain by 4.7 log10 CFU/g after 4 days of therapy and sterilized 6/11 vegetations compared to 3.4 log10 CFU/g with 3/10 vegetations sterilized for a regimen of twice-daily vancomycin, 30 mg/kg; these differences were not statistically significant. Telavancin was significantly more effective than vancomycin in the VISA model, producing a 5.5 log10 CFU/g reduction versus no reduction in CFU with vancomycin. In experiments comparing 2-day regimens of telavancin at 30 mg/kg and 50 mg/kg twice daily, organisms were rapidly eliminated from vegetations, but the effect was not different between the two doses. These results suggest that telavancin may be an effective treatment for endocarditis and other serious staphylococcal infections accompanied by bacteremia, including infections caused by staphylococci not susceptible to vancomycin.

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