scholarly journals Dataset of single Mycobacterium tuberculosis bacteria cells with different antibiotic susceptibility obtained by Raman spectroscopy

Data in Brief ◽  
2018 ◽  
Vol 21 ◽  
pp. 2430-2434
Author(s):  
Andrey Zyubin ◽  
Anastasia Lavrova ◽  
Olga Manicheva ◽  
Marine Dogonadze ◽  
Ilia Samusev
Keyword(s):  
Raman Spectroscopy ◽  
Mycobacterium Tuberculosis ◽  
Antibiotic Susceptibility

scholarly journals Replication Rates of Mycobacterium tuberculosis in Human Macrophages Do Not Correlate with Mycobacterial Antibiotic Susceptibility

PLoS ONE ◽  
2014 ◽  
Vol 9 (11) ◽  
pp. e112426 ◽  
Author(s):  
Johanna Raffetseder ◽  
Elsje Pienaar ◽  
Robert Blomgran ◽  
Daniel Eklund ◽  
Veronika Patcha Brodin ◽  
...  
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Antibiotic Susceptibility ◽  
Human Macrophages

scholarly journals Detecting Phenotypically Resistant Mycobacterium tuberculosis Using Wavelength Modulated Raman Spectroscopy

2018 ◽  
pp. 41-50 ◽  
Author(s):  
Vincent O. Baron ◽  
Mingzhou Chen ◽  
Simon O. Clark ◽  
Ann Williams ◽  
Kishan Dholakia ◽  
...  
Keyword(s):  
Raman Spectroscopy ◽  
Mycobacterium Tuberculosis

scholarly journals Effect of common and experimental anti-tuberculosis treatments onMycobacterium tuberculosisgrowing as biofilms

PeerJ ◽  
2016 ◽  
Vol 4 ◽  
pp. e2717 ◽  
Author(s):  
James P. Dalton ◽  
Benedict Uy ◽  
Narisa Phummarin ◽  
Brent R. Copp ◽  
William A. Denny ◽  
...  
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Lung Disease ◽  
Antibiotic Treatment ◽  
Antibiotic Susceptibility ◽  
Minimum Inhibitory Concentrations ◽  
Light Levels ◽  
Solid Media ◽  
H37rv Strain ◽  
Before And After ◽  
Phenotypic State

Much is known regarding the antibiotic susceptibility of planktonic cultures ofMycobacterium tuberculosis, the bacterium responsible for the lung disease tuberculosis (TB). As planktonically-grownM. tuberculosisare unlikely to be entirely representative of the bacterium during infection, we set out to determine how effective a range of anti-mycobacterial treatments were againstM. tuberculosisgrowing as a biofilm, a bacterial phenotype known to be more resistant to antibiotic treatment. Light levels from bioluminescently-labelledM. tuberculosisH37Rv (strain BSG001) were used as a surrogate for bacterial viability, and were monitored before and after one week of treatment. After treatment, biofilms were disrupted, washed and inoculated into fresh broth and plated onto solid media to rescue any surviving bacteria. We found that in this phenotypic stateM. tuberculosiswas resistant to the majority of the compounds tested. Minimum inhibitory concentrations (MICs) increased by 20-fold to greater than 1,000-fold, underlying the potential of this phenotype to cause significant problems during treatment.

Raman spectroscopy experimental spectra simulation for identification in Mycobacterium tuberculosis strains with different antibiotic resistance

2021 ◽  
Author(s):  
Andrey Y. Zyubin ◽  
Anastasia Lavrova ◽  
Eugenie Postnicov ◽  
Olga Manicheva ◽  
Marine Dogonadze ◽  
...  
Keyword(s):  
Raman Spectroscopy ◽  
Antibiotic Resistance ◽  
Mycobacterium Tuberculosis
Sign in / Sign up

Export Citation Format

Share Document