P50. Role of glioma produced CM1 in the brain tumor tropism of human neural stem cells

2010 ◽  
Vol 80 ◽  
pp. S33-S34
Author(s):  
J. Jeon ◽  
S. Cho ◽  
K. Cho ◽  
Y. Lee ◽  
M. Lee
Keyword(s):  
Stem Cells ◽  
Brain Tumor ◽  
Neural Stem Cells ◽  
Human Neural Stem Cells ◽  
Tumor Tropism ◽  
The Brain

scholarly journals Brain Tumor Tropism of Transplanted Human Neural Stem Cells Is Induced by Vascular Endothelial Growth Factor

Neoplasia ◽  
2005 ◽  
Vol 7 (6) ◽  
pp. 623-630 ◽  
Author(s):  
Nils Ole Schmidt ◽  
Wojciech Przylecki ◽  
Wendy Yang ◽  
Mateo Ziu ◽  
Yang Teng ◽  
...  
Keyword(s):  
Stem Cells ◽  
Vascular Endothelial Growth Factor ◽  
Brain Tumor ◽  
Growth Factor ◽  
Neural Stem Cells ◽  
Vascular Endothelial ◽  
Human Neural Stem Cells ◽  
Tumor Tropism ◽  
Endothelial Growth Factor

Glioma-produced extracellular matrix influences brain tumor tropism of human neural stem cells

2006 ◽  
Vol 79 (2) ◽  
pp. 125-133 ◽  
Author(s):  
Mateo Ziu ◽  
Nils Ole Schmidt ◽  
Theresa G. Cargioli ◽  
Karen S. Aboody ◽  
Peter McL. Black ◽  
...  
Keyword(s):  
Stem Cells ◽  
Extracellular Matrix ◽  
Brain Tumor ◽  
Neural Stem Cells ◽  
Human Neural Stem Cells ◽  
Tumor Tropism

Adenosine triphosphate induces proliferation of human neural stem cells: Role of calcium and p70 ribosomal protein S6 kinase

2003 ◽  
Vol 72 (3) ◽  
pp. 352-362 ◽  
Author(s):  
Jae K. Ryu ◽  
Hyun B. Choi ◽  
Kozo Hatori ◽  
Rochelle L. Heisel ◽  
Steven L. Pelech ◽  
...  
Keyword(s):  
Stem Cells ◽  
Neural Stem Cells ◽  
Ribosomal Protein ◽  
Adenosine Triphosphate ◽  
S6 Kinase ◽  
Human Neural Stem Cells ◽  
Ribosomal Protein S6 ◽  
Ribosomal Protein S6 Kinase

Stereological Analysis on Migration of Human Neural Stem Cells in the Brain of Rats Bearing Glioma

Neurosurgery ◽  
2010 ◽  
Vol 66 (2) ◽  
pp. 333-342 ◽  
Author(s):  
Jae-Ho Kim ◽  
Jong-Eun Lee ◽  
Seung U. Kim ◽  
Kyung-Gi Cho
Keyword(s):  
Stem Cells ◽  
Neural Stem Cells ◽  
Stereological Analysis ◽  
Human Neural Stem Cells ◽  
The Brain

Human Neural Stem Cells Genetically Modified to Express Human Nerve Growth Factor (NGF) Gene Restore Cognition in the Mouse with Ibotenic Acid-Induced Cognitive Dysfunction

2012 ◽  
Vol 21 (11) ◽  
pp. 2487-2496 ◽  
Author(s):  
Hong J. Lee ◽  
In J. Lim ◽  
Seung W. Park ◽  
Yun B. Kim ◽  
Yong Ko ◽  
...  
Keyword(s):  
Stem Cells ◽  
Nerve Growth Factor ◽  
Cognitive Function ◽  
Growth Factor ◽  
Neural Stem Cells ◽  
Cholinergic Neurons ◽  
Ibotenic Acid ◽  
Learning Deficit ◽  
Human Neural Stem Cells ◽  
The Brain

Alzheimer's disease (AD) is characterized by degeneration and loss of neurons and synapses throughout the brain, causing the progressive decline in cognitive function leading to dementia. No effective treatment is currently available. Nerve growth factor (NGF) therapy has been proposed as a potential treatment of preventing degeneration of basal forebrain cholinergic neurons in AD. In a previous study, AD patient's own fibroblasts genetically modified to produce NGF were transplanted directly into the brain and protected cholinergic neurons from degeneration and improved cognitive function in AD patients. In the present study, human neural stem cells (NSCs) are used in place of fibroblasts to deliver NGF in ibotenic acid-induced learning-deficit rats. Intrahippocampal injection of ibotenic acid caused severe neuronal loss, resulting in learning and memory deficit. NGF protein released by F3.NGF human NSCs in culture medium is 10-fold over the control F3 naive NSCs at 1.2 μg/106 cells/day. Overexpression of NGF in F3.NGF cells induced improved survival of NSCs from cytotoxic agents H2O2, Aβ, or ibotenic acid in vitro. Intrahippocampal transplantation of F3.NGF cells was found to express NGF and fully improved the learning and memory function of ibotenic acid-challenged animals. Transplanted F3.NGF cells were found all over the brain and differentiated into neurons and astrocytes. The present study demonstrates that human NSCs overexpressing NGF improve cognitive function of learning-deficit model mice.

Maintenance of Neural Stem Cells in the Brain: Role of Notch Signaling

2011 ◽  
pp. 31-39 ◽  
Author(s):  
Ryoichiro Kageyama ◽  
Hiromi Shimojo ◽  
Toshiyuki Ohtsuka ◽  
Itaru Imayoshi
Keyword(s):  
Stem Cells ◽  
Neural Stem Cells ◽  
Notch Signaling ◽  
The Brain

scholarly journals The role of microRNAs in human neural stem cells, neuronal differentiation and subtype specification

2014 ◽  
Vol 359 (1) ◽  
pp. 47-64 ◽  
Author(s):  
Laura Stappert ◽  
Beate Roese-Koerner ◽  
Oliver Brüstle
Keyword(s):  
Stem Cells ◽  
Neural Stem Cells ◽  
Neuronal Differentiation ◽  
Human Neural Stem Cells

To be or not to be accepted: the role of immunogenicity of neural stem cells following transplantation into the brain in animal and human studies

2011 ◽  
Vol 33 (6) ◽  
pp. 619-626 ◽  
Author(s):  
Philipp Capetian ◽  
Máté Döbrössy ◽  
Christian Winkler ◽  
Marco Prinz ◽  
Guido Nikkhah
Keyword(s):  
Stem Cells ◽  
Neural Stem Cells ◽  
Human Studies ◽  
The Brain
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