Proportional incidence of interval colorectal cancer in a large population-based faecal immunochemical test screening programme

2020 ◽  
Vol 52 (4) ◽  
pp. 452-456 ◽  
Author(s):  
Silvia Mancini ◽  
Lauro Bucchi ◽  
Orietta Giuliani ◽  
Alessandra Ravaioli ◽  
Rosa Vattiato ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Screening Programme ◽  
Large Population ◽  
Population Based ◽  
Faecal Immunochemical Test ◽  
Immunochemical Test ◽  
Interval Colorectal Cancer ◽  
Proportional Incidence

scholarly journals Impact of screening programme using the faecal immunochemical test on stage of colorectal cancer: Results from the IMPATTO study

2019 ◽  
Vol 145 (1) ◽  
pp. 110-121 ◽  
Author(s):  
Massimo Vicentini ◽  
Manuel Zorzi ◽  
Emanuela Bovo ◽  
Pamela Mancuso ◽  
Marco Zappa ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Screening Programme ◽  
Faecal Immunochemical Test ◽  
Immunochemical Test

scholarly journals Interval cancers after negative immunochemical test compared to screen and non-responders’ detected cancers in Slovenian colorectal cancer screening programme

2018 ◽  
Vol 52 (4) ◽  
pp. 413-421 ◽  
Author(s):  
Dominika Novak Mlakar ◽  
Tatjana Kofol Bric ◽  
Ana Lucija Škrjanec ◽  
Mateja Krajc
Keyword(s):  
Colorectal Cancer ◽  
Cancer Screening ◽  
Colorectal Cancer Screening ◽  
Screening Test ◽  
Screening Programme ◽  
Interval Cancers ◽  
Faecal Immunochemical Test ◽  
Test Sensitivity ◽  
Cancer Screening Programme ◽  
Immunochemical Test

Abstract Background We assessed the incidence and characteristics of interval cancers after faecal immunochemical occult blood test and calculated the test sensitivity in Slovenian colorectal cancer screening programme. Patients and methods The analysis included the population aged between 50 to 69 years, which was invited for screening between April 2011 and December 2012. The persons were followed-up until the next foreseen invitation, in average for 2 years. The data on interval cancers and cancers in non-responders were obtained from cancer registry. Gender, age, years of schooling, the cancer site and stage were compared among three observed groups. We used the proportional incidence method to calculate the screening test sensitivity. Results Among 502,488 persons invited for screening, 493 cancers were detected after positive screening test, 79 interval cancers after negative faecal immunochemical test and 395 in non-responders. The proportion of interval cancers was 13.8%. Among the three observed groups cancers were more frequent in men (p = 0.009) and in persons aged 60+ years (p < 0.001). Comparing screen detected and cancers in non-responders with interval cancers more interval cancers were detected in persons with 10 years of schooling or more (p = 0.029 and p = 0.001), in stage III (p = 0.027) and IV (p < 0.001), and in right hemicolon (p < 0.001). Interval cancers were more frequently in stage I than non-responders cancers (p = 0.004). Test sensitivity of faecal immunochemical test was 88.45%. Conclusions Interval cancers in Slovenian screening programme were detected in expected proportions as in similar programmes. Test sensitivity was among the highest when compared to similar programmes and was accomplished using test kit for two stool samples.

Participation in a population-based screening for colorectal cancer using the faecal immunochemical test decreases mortality in 5 years

2019 ◽  
Vol 31 (2) ◽  
pp. 197-204 ◽  
Author(s):  
Isabel Idigoras Rubio ◽  
Eunate Arana-Arri ◽  
Isabel Portillo Villares ◽  
Isabel Bilbao Iturribarrria ◽  
Lorea Martínez-Indart ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Population Based ◽  
Faecal Immunochemical Test ◽  
Immunochemical Test

Colonoscopy may be weak link in organised colorectal cancer screening programme with faecal immunochemical test

2021 ◽  
pp. 096914132110611
Author(s):  
Bernard Denis ◽  
Isabelle Gendre
Keyword(s):  
Colorectal Cancer ◽  
Cancer Screening ◽  
Colorectal Cancer Screening ◽  
Screening Programme ◽  
Lesion Detection ◽  
Faecal Immunochemical Test ◽  
Adenoma Detection ◽  
Cancer Screening Programme ◽  
Immunochemical Test ◽  
Serrated Lesion

Objective To evaluate the quality of colonoscopies performed after a positive faecal immunochemical test in the French colorectal cancer screening programme. Methods Retrospective analysis of all colonoscopies performed between 2015 and 2019 after a positive quantitative faecal immunochemical test in the population-based colorectal cancer screening programme organised in Alsace, part of the French programme. The following indicators were evaluated: annual colonoscopy volume, caecal intubation rate, adenoma detection rate, proximal serrated lesion detection rate and proportion of patients referred directly to surgery for benign polyp management. Endoscopists who performed <30 faecal immunochemical test positive colonoscopies were non-assessable. Results Overall, 13,455 faecal immunochemical test-positive colonoscopies performed by 116 community gastroenterologists were included, 13,067 of them by 80 assessable endoscopists. The overall caecal intubation, adenoma detection and proximal serrated lesion detection rates were 97.9%, 57.6% and 7.6%, respectively. They were <90%, <45% and <1% for 1.3%, 12.5% and 6.3% of the endoscopists, respectively. Overall, 1028 (7.9%) individuals were examined by 13 low-performing endoscopists and 328 (2.4%) individuals by 33 low-volume non-assessable endoscopists. Among 9133 individuals harbouring polyps, 155 (1.7%) had unwarranted surgery for a benign polyp. Overall, 1487 individuals (11.1%; 95% confidence interval 10.5–11.6) were not given the best possible chances, whereas 5545 individuals (41.2%; 95% confidence interval 40.4–42.0) were offered the best possible chances by 37 endoscopists. Conclusions At programme level, the key performance indicators evaluated largely exceeded the target standards. At individual level, at least one in nine individuals was not given the best possible chances during faecal immunochemical test-positive colonoscopies by a minority of poor-performing and/or low-volume endoscopists.

The role of area-level deprivation and gender in participation in population-based faecal immunochemical test (FIT) colorectal cancer screening

2016 ◽  
Vol 93 ◽  
pp. 198-203 ◽  
Author(s):  
Nicholas Clarke ◽  
Deirdre McNamara ◽  
Patricia M. Kearney ◽  
Colm A. O'Morain ◽  
Nikki Shearer ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Screening ◽  
Colorectal Cancer Screening ◽  
Population Based ◽  
Faecal Immunochemical Test ◽  
Immunochemical Test ◽  
And Gender

Faecal immunochemical test-based colorectal cancer screening programme SVIT in Slovenia

2014 ◽  
Vol 23 (4) ◽  
pp. 235-239 ◽  
Author(s):  
Bojan Tepeš ◽  
Borut Štabuc ◽  
Milan Stefanovič ◽  
Matej Bračko ◽  
Snežana Frkovič Grazio ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Cancer Screening ◽  
Colorectal Cancer Screening ◽  
Screening Programme ◽  
Faecal Immunochemical Test ◽  
Cancer Screening Programme ◽  
Immunochemical Test

scholarly journals Faecal immunochemical test after negative colonoscopy may reduce the risk of incident colorectal cancer in a population-based screening programme

Gut ◽  
2020 ◽  
pp. gutjnl-2020-320761
Author(s):  
Szu-Min Peng ◽  
Wen-Feng Hsu ◽  
Ying-Wei Wang ◽  
Li-Ju Lin ◽  
Amy Ming-Fang Yen ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Screening Programme ◽  
Multivariable Analysis ◽  
Study Cohort ◽  
Diagnostic Colonoscopy ◽  
Cox Regression Analysis ◽  
Faecal Immunochemical Test ◽  
Adenoma Detection ◽  
Increased Risk ◽  
Immunochemical Test

ObjectiveSubjects with a positive faecal immunochemical test (FIT) have a much higher likelihood of advanced neoplasms than the general population. Whether FIT-positive subjects with negative colonoscopy should receive subsequent FIT screening remain unclear.DesignSubjects with a negative colonoscopy after positive FIT in the first screening in the Taiwanese Colorectal Cancer (CRC) Screening Program 2004–2009 were followed until the end of 2014. CRC incidence was compared between those who did and did not receive subsequent FIT screening. Cox regression analysis was conducted, adjusting for major confounders to investigate whether subsequent FIT was associated with lower risk of incident CRC.ResultsThe study cohort was comprised of 9179 subjects who had negative diagnostic colonoscopy after positive FIT in 2004–2009, of whom 6195 received subsequent FIT during the study period. The CRC incidence (per 1000 person years) was 1.34 in those who received subsequent FIT and 2.69 in those who did not, with corresponding adjusted HR (aHR) of 0.47 (95% CI 0.31 to 0.71). Lower adenoma detection rate of diagnostic colonoscopy was associated with higher risk of incident CRC but became non-significant in multivariable analysis after adjustment for subsequent FIT. Higher baseline faecal haemoglobin concentration (FHbC, μg haemoglobin/g faeces) was associated with increased risk of incident CRC (reference: FHbC=20–39; aHR=1.93 (1.04–3.56), 0.95 (0.45–2.00), 2.26 (1.16–4.43) and 2.44 (1.44–4.12) for FHbC=40–59, 60–99, 100–149 and ≥150, respectively).ConclusionSubsequent FIT should be scheduled after negative colonoscopy to detect missed neoplasms and reduce the risk of incident CRC in a national FIT screening programme.

Sign in / Sign up

Export Citation Format

Share Document