Systematic review with meta-analysis: The prevalence, risk factors and outcomes of upper gastrointestinal tract crohn's disease

2021 ◽  
Author(s):  
Yip Han Chin ◽  
Cheng Han Ng ◽  
Snow Yunni Lin ◽  
Sneha Rajiv Jain ◽  
Gwyneth Kong ◽  
...  
Keyword(s):  
Risk Factors ◽  
Systematic Review ◽  
Crohn’S Disease ◽  
Gastrointestinal Tract ◽  
Crohn's Disease ◽  
Meta Analysis ◽  
Upper Gastrointestinal Tract ◽  
Upper Gastrointestinal

scholarly journals Upper Gastrointestinal Tract Involvement in Crohn’s Disease: Frequency, Risk Factors, and Disease Course

2018 ◽  
Vol 12 (12) ◽  
pp. 1399-1409 ◽  
Author(s):  
Thomas Greuter ◽  
Alberto Piller ◽  
Nicolas Fournier ◽  
Ekaterina Safroneeva ◽  
Alex Straumann ◽  
...  
Keyword(s):  
Risk Factors ◽  
Crohn’S Disease ◽  
Gastrointestinal Tract ◽  
Crohn's Disease ◽  
Upper Gastrointestinal Tract ◽  
Disease Course ◽  
Tract Involvement ◽  
Upper Gastrointestinal

scholarly journals Upper Gastrointestinal Crohn’s Disease: Literature Review and Case Presentation

2019 ◽  
Vol 2019 ◽  
pp. 1-5 ◽  
Author(s):  
Soorya N. Aggarwal ◽  
Yana Cavanagh ◽  
Lan Wang ◽  
Amer Akmal ◽  
Matthew A. Grossman
Keyword(s):  
Crohn’S Disease ◽  
Gastrointestinal Tract ◽  
Iron Deficiency ◽  
Crohn's Disease ◽  
Fecal Calprotectin ◽  
Upper Gastrointestinal Tract ◽  
Laboratory Evaluation ◽  
Deficiency Anemia ◽  
Endoscopic Evaluation ◽  
Upper Gastrointestinal

Upper gastrointestinal tract predominant Crohn’s Disease (CD) remains an elusive clinical entity, manifesting limited or vague symptomatology, eluding clinical suspicion, and delaying subsequent diagnostic evaluation. As a result, it has not been widely described and there is a lack of clear recommendations for diagnosis or management. Standard IBD evaluation including serologic testing, imaging, and endoscopy may initially not be fruitful. Furthermore, endoscopic evaluation may be grossly normal in patients without long standing-disease. We describe an 18-year-old male who presented with only unexplained, persistent iron-deficiency anemia. Extensive outpatient testing including multiple endoscopic evaluations with standard biopsies was unfruitful. Ultimately, a positive fecal calprotectin prompted enteroscopy with endoscopic mucosal resection (EMR) in an effort to obtain a larger, deeper tissue specimen. Grossly cobblestoned mucosa along with histopathology revealing focal crypt abscesses, chronic inflammation in the lamina propria, and superficial foveolar epithelial regenerative changes were consistent with CD. This patient’s case illustrates the need for a high degree of suspicion for CD in patients with unexplained or persistent iron deficiency anemias. Persistent investigation yielded an elevation in fecal calprotectin suggesting underlying gastrointestinal inflammation and prompted advanced endoscopic evaluation with EMR. Waxing and waning tissue findings are characteristic of CD and pose a unique challenge in patients with upper gastrointestinal predominant pathology. As such, diligent workup including laboratory evaluation, imaging, and serial endoscopy is critical to establish pathology and dictate subsequent management in IBD, especially upper gastrointestinal tract predominant CD.

(027) Isolated Crohn’s disease of the upper gastrointestinal tract

2009 ◽  
Vol 10 (2) ◽  
pp. AB19
Author(s):  
N. Chouqi ◽  
F. Ajana ◽  
I. Benelbarhdadi ◽  
A. Timraz ◽  
W. Essamri ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Gastrointestinal Tract ◽  
Crohn's Disease ◽  
Upper Gastrointestinal Tract ◽  
Upper Gastrointestinal

Endoscopic and Bioptic Findings in the Upper Gastrointestinal Tract in Patients with Crohn's Disease

Endoscopy ◽  
1993 ◽  
Vol 25 (04) ◽  
pp. 282-286 ◽  
Author(s):  
M. Alcántara ◽  
R. Rodriguez ◽  
J. L. M. Potenciano ◽  
J. L. Carrobles ◽  
C. Muñoz ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Gastrointestinal Tract ◽  
Crohn's Disease ◽  
Upper Gastrointestinal Tract ◽  
Upper Gastrointestinal

Clinical Features and Prognosis of Crohn’s Disease with Upper Gastrointestinal Tract Phenotype in Chinese Patients

2019 ◽  
Vol 64 (11) ◽  
pp. 3291-3299 ◽  
Author(s):  
Xiao-Wei Sun ◽  
Juan Wei ◽  
Zhao Yang ◽  
Xin-Xin Jin ◽  
Hai-Jun Wan ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Gastrointestinal Tract ◽  
Crohn's Disease ◽  
Clinical Features ◽  
Upper Gastrointestinal Tract ◽  
Chinese Patients ◽  
Upper Gastrointestinal

Tu1225 Upper Gastrointestinal Tract Involvement in Crohn's Disease Requiring Anti-TNF Therapy: Clinical Characteristics

2012 ◽  
Vol 142 (5) ◽  
pp. S-779
Author(s):  
William J. Tremaine ◽  
William A. Faubion ◽  
Darrell S. Pardi ◽  
Lawrence J. Timmons ◽  
Sunanda V. Kane ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Gastrointestinal Tract ◽  
Crohn's Disease ◽  
Clinical Characteristics ◽  
Upper Gastrointestinal Tract ◽  
Tract Involvement ◽  
Upper Gastrointestinal

scholarly journals Upper Gastrointestinal Tract Crohn's Disease

1990 ◽  
Vol 4 (1) ◽  
pp. 26-32 ◽  
Author(s):  
Hugh J Freeman
Keyword(s):  
Crohn’S Disease ◽  
Gastrointestinal Tract ◽  
Crohn's Disease ◽  
Treatment Options ◽  
Upper Gastrointestinal Tract ◽  
Distal Intestine ◽  
The Subject ◽  
Atypical Presentations ◽  
Upper Gastrointestinal

Crohn's disease may involve any site within the gastrointestinal tract. Usually pathology is present in the ileum and/or colon, but atypical presentations may occur with apparently 'isolated' involvement of the oropharynx, esophagus or gastroduodenum. If changes typical of Crohn's disease are detected in the upper gastrointestinal tract, then a careful assessment is required involving radiographic, endoscopic and histologic studies to determine if pathology is present in more distal intestine. In addition , microbiologic studies may be important to exclude infectious causes, especially of granulomas. If these studies are negative, prolonged follow-up may be required to establish a diagnosis of Crohn's disease. Although upper gastrointestinal involvement is increasingly recognized as a significant cause of morbidity in Crohn's disease, the treatment options are limited , largely anecdotal and need to be the subject of detailed epidemiologic investigation and clinical trials.

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