NADPH-independent inactivation of CYP2B6 by pyrrolobenzodiazepine dimer and potential impact on time-dependent inhibition assay of covalent inhibitors

Drug Metabolism and Pharmacokinetics ◽

10.1016/j.dmpk.2017.11.180 ◽

2018 ◽

Vol 33 (1) ◽

pp. S52-S53

Author(s):

Mika Kosaka ◽

Donglu Zhang ◽

Jing Wang ◽

Zhengyin Yan ◽

Simon Wong

Keyword(s):

Time Dependent ◽

Inhibition Assay ◽

Dependent Inhibition ◽

Covalent Inhibitors ◽

Pyrrolobenzodiazepine Dimer ◽

Potential Impact ◽

Time Dependent Inhibition

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Use of a Multistaged Time-Dependent Inhibition Assay to Assess the Impact of Intestinal Metabolism on Drug-Drug Interaction Potential

Drug Metabolism and Disposition ◽

10.1124/dmd.111.043257 ◽

2011 ◽

Vol 40 (3) ◽

pp. 467-473 ◽

Author(s):

Michael Zientek ◽

Deepak Dalvie

Keyword(s):

Drug Interaction ◽

Interaction Potential ◽

Time Dependent ◽

Intestinal Metabolism ◽

Inhibition Assay ◽

Dependent Inhibition ◽

Drug Drug Interaction ◽

Time Dependent Inhibition

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Human Hepatocyte Suspensions as a Model to Assess Reversible and Time-Dependent Inhibition of CYP1A2, CYP2B6, CYP2C8, CYP2C9, CYP2C19, CYP2D6 and CYP3A4

10.26226/morressier.57ea3d69d462b8028d88e3cf ◽

2016 ◽

Author(s):

George Zhang

Keyword(s):

Human Hepatocyte ◽

Time Dependent ◽

Dependent Inhibition ◽

Time Dependent Inhibition

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Statistical Methods for Analysis of Time-Dependent Inhibition of Cytochrome P450 Enzymes

Drug Metabolism and Disposition ◽

10.1124/dmd.112.047233 ◽

2012 ◽

Vol 40 (12) ◽

pp. 2289-2296 ◽

Author(s):

Phillip Yates ◽

Heather Eng ◽

Li Di ◽

R. Scott Obach

Keyword(s):

Cytochrome P450 ◽

Statistical Methods ◽

Time Dependent ◽

Cytochrome P450 Enzymes ◽

Dependent Inhibition ◽

Time Dependent Inhibition

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Time-dependent inhibition of hindlimb somatic afferent transmission within nucleus tractus solitarius: An in vivo intracellular recording study

Neuroscience ◽

10.1016/0306-4522(95)00156-d ◽

1995 ◽

Vol 68 (2) ◽

pp. 445-453 ◽

Author(s):

G.M. Toney ◽

S.W. Mifflin

Keyword(s):

Intracellular Recording ◽

Nucleus Tractus Solitarius ◽

Time Dependent ◽

Dependent Inhibition ◽

Time Dependent Inhibition

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Combination of GSH Trapping and Time-Dependent Inhibition Assays as a Predictive Method of Drugs Generating Highly Reactive Metabolites

Drug Metabolism and Disposition ◽

10.1124/dmd.111.039180 ◽

2011 ◽

Vol 39 (7) ◽

pp. 1247-1254 ◽

Author(s):

Shintaro Nakayama ◽

Hideo Takakusa ◽

Akiko Watanabe ◽

Yoshihiro Miyaji ◽

Wataru Suzuki ◽

...

Keyword(s):

Time Dependent ◽

Reactive Metabolites ◽

Predictive Method ◽

Dependent Inhibition ◽

Time Dependent Inhibition

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Effect of Solvents on the Time-Dependent Inhibition of CYP3A4 and the Biotransformation of AZD3839 in Human Liver Microsomes and Hepatocytes

Drug Metabolism and Disposition ◽

10.1124/dmd.112.047597 ◽

2012 ◽

Vol 41 (1) ◽

pp. 159-169 ◽

Author(s):

Jenny Aasa ◽

Yin Hu ◽

Göran Eklund ◽

Anders Lindgren ◽

Pawel Baranczewski ◽

...

Keyword(s):

Human Liver ◽

Liver Microsomes ◽

Human Liver Microsomes ◽

Time Dependent ◽

Effect Of Solvents ◽

Dependent Inhibition ◽

Time Dependent Inhibition

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Time-dependent inhibition of Bacillus stearothermophilus alanine racemase by (1-aminoethyl)phosphonate isomers by isomerization to noncovalent slowly dissociating enzyme-(1-aminoethyl)phosphonate complexes

Biochemistry ◽

10.1021/bi00359a029 ◽

1986 ◽

Vol 25 (11) ◽

pp. 3275-3282 ◽

Author(s):

Bernard Badet ◽

Kenji Inagaki ◽

Kenji Soda ◽

Christopher T. Walsh

Keyword(s):

Bacillus Stearothermophilus ◽

Time Dependent ◽

Alanine Racemase ◽

Dependent Inhibition ◽

Time Dependent Inhibition

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Time-Dependent Inhibition of Oxotremorine-Induced Cerebral Hyperemia by N ω -Nitro- l -Arginine in Cats

Stroke ◽

10.1161/01.str.26.11.2160 ◽

1995 ◽

Vol 26 (11) ◽

pp. 2160-2165 ◽

Author(s):

Charisse S. Tietjen ◽

Jeffrey R. Kirsch ◽

Nathalie Clavier ◽

Richard J. Traystman

Keyword(s):

Time Dependent ◽

Dependent Inhibition ◽

Time Dependent Inhibition

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Numerical Analysis of Time-Dependent Inhibition by MDMA

Drug Metabolism and Disposition ◽

10.1124/dmd.119.089268 ◽

2019 ◽

Vol 48 (1) ◽

pp. 1-7

Author(s):

John T. Rodgers ◽

Jeffrey P. Jones

Keyword(s):

Numerical Analysis ◽

Time Dependent ◽

Dependent Inhibition ◽

Time Dependent Inhibition

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A Physiologically Based Pharmacokinetic Model of Voriconazole Integrating Time-Dependent Inhibition of CYP3A4, Genetic Polymorphisms of CYP2C19 and Predictions of Drug–Drug Interactions

Clinical Pharmacokinetics ◽

10.1007/s40262-019-00856-z ◽

2019 ◽

Vol 59 (6) ◽

pp. 781-808 ◽

Author(s):

Xia Li ◽

Sebastian Frechen ◽

Daniel Moj ◽

Thorsten Lehr ◽

Max Taubert ◽

...

Keyword(s):

Drug Interactions ◽

Genetic Polymorphisms ◽

Pharmacokinetic Model ◽

Time Dependent ◽

Physiologically Based Pharmacokinetic Model ◽

Physiologically Based Pharmacokinetic ◽

Physiologically Based ◽

Dependent Inhibition ◽

Time Dependent Inhibition

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