pyrrolobenzodiazepine dimer Recently Published Documents

Drug Conjugates ◽

cIRCR201-dPBD, a Novel Pyrrolobenzodiazepine Dimer-Containing Site-Specific Antibody–Drug Conjugate Targeting c-Met Overexpression Tumors

ACS Omega ◽

10.1021/acsomega.0c03102 ◽

2020 ◽

Vol 5 (40) ◽

pp. 25798-25809

Author(s):

Byeongkwi Min ◽

Jonghwa Jin ◽

Hyeree Kim ◽

Nam-Gu Her ◽

Changsik Park ◽

...

Keyword(s):

Specific Antibody ◽

Antibody Drug Conjugate ◽

Site Specific ◽

Drug Conjugate ◽

The Role of Specific ATP-Binding Cassette Transporters in the Acquired Resistance to Pyrrolobenzodiazepine Dimer–Containing Antibody–Drug Conjugates

Molecular Cancer Therapeutics ◽

10.1158/1535-7163.mct-20-0222 ◽

2020 ◽

Vol 19 (9) ◽

pp. 1856-1865 ◽

Cited By ~ 1

Author(s):

Simon Corbett ◽

Shiran Huang ◽

Francesca Zammarchi ◽

Philip W. Howard ◽

Patrick H. van Berkel ◽

...

Keyword(s):

Acquired Resistance ◽

Atp Binding ◽

Drug Conjugates ◽

Atp Binding Cassette Transporters ◽

Antibody Drug ◽

Atp Binding Cassette

Anti-CD123-Pyrrolobenzodiazepine Dimer Antibody Drug Conjugate SGN-CD123A

10.32388/j6ii5b ◽

2020 ◽

Author(s):

Keyword(s):

Antibody Drug Conjugate ◽

Drug Conjugate ◽

Hydrophobic interaction chromatography (HIC) method development and characterization of resolved drug-load variants in site-specifically conjugated pyrrolobenzodiazepine dimer-based antibody drug conjugates (PBD-ADCs)

Journal of Pharmaceutical and Biomedical Analysis ◽

10.1016/j.jpba.2019.113027 ◽

2020 ◽

Vol 179 ◽

pp. 113027 ◽

Cited By ~ 1

Author(s):

Thamara Janaratne ◽

Xiu C. Wang ◽

Calvin Becker ◽

Yanqun Zhao ◽

Rob Leanna ◽

...

Keyword(s):

Hydrophobic Interaction ◽

Method Development ◽

Hydrophobic Interaction Chromatography ◽

Drug Load ◽

Drug Conjugates ◽

Synthesis and evaluation of pyrrolobenzodiazepine dimer antibody-drug conjugates with dual β-glucuronide and dipeptide triggers

European Journal of Medicinal Chemistry ◽

10.1016/j.ejmech.2019.06.044 ◽

2019 ◽

Vol 179 ◽

pp. 591-607 ◽

Cited By ~ 1

Author(s):

Stephen J. Gregson ◽

Allison M. Barrett ◽

Neki V. Patel ◽

Gyoung-Dong Kang ◽

Davide Schiavone ◽

...

Keyword(s):

Drug Conjugates ◽

Orphan designation: CD33-directed antibody-drug conjugate consisting of an antibody conjugated to a DNA cross-linking pyrrolobenzodiazepine dimer drug (vadastuximab talirine), Treatment of acute myeloid leukaemia

Case Medical Research ◽

10.31525/cmr-1740561 ◽

2019 ◽

Author(s):

Keyword(s):

Acute Myeloid Leukaemia ◽

Myeloid Leukaemia ◽

Cross Linking ◽

Antibody Drug Conjugate ◽

Orphan Designation ◽

Drug Conjugate ◽

Acute Myeloid ◽

Design and characterization of homogenous antibody-drug conjugates with a drug-to-antibody ratio of one prepared using an engineered antibody and a dual-maleimide pyrrolobenzodiazepine dimer

mAbs ◽

10.1080/19420862.2019.1578611 ◽

2019 ◽

Vol 11 (3) ◽

pp. 500-515 ◽

Cited By ~ 3

Author(s):

Jason B. White ◽

Ryan Fleming ◽

Luke Masterson ◽

Ben T. Ruddle ◽

Haihong Zhong ◽

...

Keyword(s):

Drug Conjugates ◽

Antibody Ratio ◽

NADPH-independent inactivation of CYP2B6 by pyrrolobenzodiazepine dimer and potential impact on time-dependent inhibition assay of covalent inhibitors

Drug Metabolism and Pharmacokinetics ◽

10.1016/j.dmpk.2017.11.180 ◽

2018 ◽

Vol 33 (1) ◽

pp. S52-S53

Author(s):

Mika Kosaka ◽

Donglu Zhang ◽

Jing Wang ◽

Zhengyin Yan ◽

Simon Wong

Keyword(s):

Time Dependent ◽

Inhibition Assay ◽

Dependent Inhibition ◽

Covalent Inhibitors ◽

Potential Impact ◽

Time Dependent Inhibition

Pyrrolobenzodiazepine Dimer Antibody–Drug Conjugates: Synthesis and Evaluation of Noncleavable Drug-Linkers

Journal of Medicinal Chemistry ◽

10.1021/acs.jmedchem.7b00736 ◽

2017 ◽

Vol 60 (23) ◽

pp. 9490-9507 ◽

Cited By ~ 17

Author(s):

Stephen J. Gregson ◽

Luke A. Masterson ◽

Binqing Wei ◽

Thomas H. Pillow ◽

Susan D. Spencer ◽

...

Keyword(s):

Drug Conjugates ◽