Hydrogen/deuterium exchange mass spectrometry for probing higher order structure of protein therapeutics: methodology and applications

Drug Discovery Today ◽

10.1016/j.drudis.2013.07.019 ◽

2014 ◽

Vol 19 (1) ◽

pp. 95-102 ◽

Author(s):

Hui Wei ◽

Jingjie Mo ◽

Li Tao ◽

Reb J. Russell ◽

Adrienne A. Tymiak ◽

...

Keyword(s):

Mass Spectrometry ◽

Higher Order ◽

Protein Therapeutics ◽

Deuterium Exchange ◽

Order Structure ◽

Hydrogen Deuterium Exchange ◽

Exchange Mass Spectrometry ◽

Hydrogen Deuterium ◽

Deuterium Exchange Mass Spectrometry

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Higher order structure characterization of protein therapeutics by hydrogen/deuterium exchange mass spectrometry

Analytical and Bioanalytical Chemistry ◽

10.1007/s00216-014-7924-3 ◽

2014 ◽

Vol 406 (26) ◽

pp. 6541-6558 ◽

Author(s):

Richard Y.-C. Huang ◽

Guodong Chen

Keyword(s):

Mass Spectrometry ◽

Higher Order ◽

Protein Therapeutics ◽

Structure Characterization ◽

Order Structure ◽

Hydrogen Deuterium Exchange ◽

Exchange Mass Spectrometry ◽

Hydrogen Deuterium ◽

Deuterium Exchange Mass Spectrometry

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Comparative higher-order structure analysis of antibody biosimilars using combined bottom-up and top-down hydrogen-deuterium exchange mass spectrometry

Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics ◽

10.1016/j.bbapap.2016.08.013 ◽

2016 ◽

Vol 1864 (12) ◽

pp. 1801-1808 ◽

Author(s):

Jingxi Pan ◽

Suping Zhang ◽

Christoph H. Borchers

Keyword(s):

Mass Spectrometry ◽

Structure Analysis ◽

Higher Order ◽

Deuterium Exchange ◽

Order Structure ◽

Hydrogen Deuterium Exchange ◽

Top Down ◽

Exchange Mass Spectrometry ◽

Hydrogen Deuterium ◽

Deuterium Exchange Mass Spectrometry

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Hydrogen/Deuterium Exchange Mass Spectrometry for Protein Higher-Order Structure Characterization

Characterization of Protein Therapeutics using Mass Spectrometry ◽

10.1007/978-1-4419-7862-2_8 ◽

2013 ◽

pp. 305-341 ◽

Author(s):

Hui Wei ◽

Adrienne A. Tymiak ◽

Guodong Chen

Keyword(s):

Mass Spectrometry ◽

Higher Order ◽

Deuterium Exchange ◽

Structure Characterization ◽

Order Structure ◽

Hydrogen Deuterium Exchange ◽

Exchange Mass Spectrometry ◽

Hydrogen Deuterium ◽

Deuterium Exchange Mass Spectrometry

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Analysis of Higher Order Structures of Proteins by Hydrogen Deuterium Exchange Mass Spectrometry

Journal of the Mass Spectrometry Society of Japan ◽

10.5702/massspec.s18-44 ◽

2018 ◽

Vol 66 (6) ◽

pp. 218-221

Author(s):

Tetsuo Torisu ◽

Hiroaki Oyama ◽

Susumu Uchiyama

Keyword(s):

Mass Spectrometry ◽

Higher Order ◽

Deuterium Exchange ◽

Hydrogen Deuterium Exchange ◽

Exchange Mass Spectrometry ◽

Hydrogen Deuterium ◽

Deuterium Exchange Mass Spectrometry ◽

Order Structures

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Impact of Glycosylation on the Comparability of the Higher-Order Structures in Idursulfase by Hydrogen–Deuterium Exchange Mass Spectrometry

Analytical Chemistry ◽

10.1021/acs.analchem.0c00661 ◽

2020 ◽

Vol 92 (12) ◽

pp. 8306-8314

Author(s):

Chris Barton ◽

Xuesong Scott Li ◽

Siyang Peter Li ◽

Brian Flaherty ◽

Lionel Sison ◽

...

Keyword(s):

Mass Spectrometry ◽

Higher Order ◽

Deuterium Exchange ◽

Hydrogen Deuterium Exchange ◽

Exchange Mass Spectrometry ◽

Hydrogen Deuterium ◽

Deuterium Exchange Mass Spectrometry ◽

Order Structures

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Detection of structural and conformational changes in ALS-causing mutant profilin-1 with hydrogen/deuterium exchange mass spectrometry and bioinformatics techniques

Metabolic Brain Disease ◽

10.1007/s11011-021-00763-y ◽

2021 ◽

Author(s):

Ahmad Shahir Sadr ◽

Zahra Abdollahpour ◽

Atousa Aliahmadi ◽

Changiz Eslahchi ◽

Mina Nekouei ◽

...

Keyword(s):

Mass Spectrometry ◽

Conformational Changes ◽

Deuterium Exchange ◽

Hydrogen Deuterium Exchange ◽

Exchange Mass Spectrometry ◽

Hydrogen Deuterium ◽

Deuterium Exchange Mass Spectrometry

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Design and Validation of In-Source Atmospheric Pressure Photoionization Hydrogen/Deuterium Exchange Mass Spectrometry with Continuous Feeding of D2O

Journal of the American Society for Mass Spectrometry ◽

10.1007/s13361-017-1831-8 ◽

2017 ◽

Vol 29 (1) ◽

pp. 85-94 ◽

Author(s):

Thamina Acter ◽

Seulgidaun Lee ◽

Eunji Cho ◽

Maeng-Joon Jung ◽

Sunghwan Kim

Keyword(s):

Mass Spectrometry ◽

Atmospheric Pressure ◽

Deuterium Exchange ◽

Hydrogen Deuterium Exchange ◽

Atmospheric Pressure Photoionization ◽

Exchange Mass Spectrometry ◽

Hydrogen Deuterium ◽

Deuterium Exchange Mass Spectrometry ◽

Continuous Feeding

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Different conformational dynamics of various active states of β-arrestin1 analyzed by hydrogen/deuterium exchange mass spectrometry

Journal of Structural Biology ◽

10.1016/j.jsb.2015.04.006 ◽

2015 ◽

Vol 190 (2) ◽

pp. 250-259 ◽

Author(s):

Dong Kyun Kim ◽

Youngjoo Yun ◽

Hee Ryung Kim ◽

Min-Duk Seo ◽

Ka Young Chung

Keyword(s):

Mass Spectrometry ◽

Conformational Dynamics ◽

Deuterium Exchange ◽

Hydrogen Deuterium Exchange ◽

Exchange Mass Spectrometry ◽

Hydrogen Deuterium ◽

Deuterium Exchange Mass Spectrometry

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Hydrogen deuterium exchange mass spectrometry in biopharmaceutical discovery and development – A review

Analytica Chimica Acta ◽

10.1016/j.aca.2016.08.006 ◽

2016 ◽

Vol 940 ◽

pp. 8-20 ◽

Author(s):

Bin Deng ◽

Cristina Lento ◽

Derek J. Wilson

Keyword(s):

Mass Spectrometry ◽

Deuterium Exchange ◽

Hydrogen Deuterium Exchange ◽

Exchange Mass Spectrometry ◽

Hydrogen Deuterium ◽

Deuterium Exchange Mass Spectrometry

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Hydrogen-Deuterium Exchange Mass Spectrometry of Phosphorylation Induced Changes in Smooth Muscle Myosin

Biophysical Journal ◽

10.1016/j.bpj.2012.11.2501 ◽

2013 ◽

Vol 104 (2) ◽

pp. 452a

Author(s):

K. Ilker Sen ◽

Brian D. Haldeman ◽

Richard Brizendine ◽

Roger Mercer ◽

Christine R. Cremo ◽

...

Keyword(s):

Mass Spectrometry ◽

Smooth Muscle ◽

Smooth Muscle Myosin ◽

Deuterium Exchange ◽

Hydrogen Deuterium Exchange ◽

Exchange Mass Spectrometry ◽

Hydrogen Deuterium ◽

Deuterium Exchange Mass Spectrometry ◽

Induced Changes ◽

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