Incremental Value of Global Longitudinal Strain in the Long-Term Prediction of Heart Failure among Patients with Coronary Artery Disease

2021 ◽  
Author(s):  
Kawa Haji ◽  
Thomas H. Marwick ◽  
Simon Stewart ◽  
Melinda Carrington ◽  
Yih-Kai Chan ◽  
...  
Keyword(s):  
Heart Failure ◽  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Longitudinal Strain ◽  
Global Longitudinal Strain ◽  
Term Prediction ◽  
Incremental Value ◽  
Artery Disease ◽  
Long Term Prediction

Additional diagnostic accuracy of global longitudinal strain at peak dobutamine stress in patients with moderate pretest probability of coronary artery disease

2020 ◽  
Vol 37 (8) ◽  
pp. 1222-1232
Author(s):  
Ahmed A. Elamragy ◽  
Mohamed A. Abdelwahab ◽  
Dalia R. Elremisy ◽  
Mohamed Hassan ◽  
Waleed A. Ammar ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Diagnostic Accuracy ◽  
Longitudinal Strain ◽  
Global Longitudinal Strain ◽  
Dobutamine Stress ◽  
Pretest Probability ◽  
Artery Disease

scholarly journals Speckle-tracking during dipyridamole stress echocardiography in the detection of myocardial ischemia in patients with suspected coronary artery disease

2020 ◽  
Vol 41 (Supplement_2) ◽  
Author(s):  
L Moderato ◽  
G Pastorini ◽  
D Lazzeroni ◽  
A Monello ◽  
G Rusticali ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Stress Echocardiography ◽  
Longitudinal Strain ◽  
Global Longitudinal Strain ◽  
Model Average ◽  
Significant Difference ◽  
Artery Disease ◽  
Dipyridamole Stress Echocardiography ◽  
Dipyridamole Stress

Abstract Background The aim of this study was to investigate the incremental value of global longitudinal strain (GLS), postsystolic strain index (PSI) and prestretch (PSE) by automated function imaging with respect to wall motion (WM) and coronary flow reserve (CFR) for the diagnosis of significant coronary artery disease (CAD) during dipyridamole stress echocardiography. Methods We retrospectibely enrolled 227 patients with known or suspected CAD, approaching our echo lab to perform a DSE; all patient underwent coronary angiography within 1 month for clinical reasons. Obstructive CAD was defined as the evidence of >70% stenosis during coronary angiogram. Obstructive CAD was detected in 143 (63%) patients, while 84 (37%) had no significant CAD. Global longitudinal strain, PSI and PSE were measured at rest and peak of the stress (after 6 minutes of 0,84mg/kg of dipyridamole infusion). Results Patient with CAD showed a significantly lower GLS at rest (−16.9±4.2 vs −18.6±3.4; p<0.01) and peak (14.9±3.8 vs −21.50±3.3; p<0.01) Figure A; the behavior of GLS was opposite, in patient with CAD showed an increase while in patient without CAD a significant decrease after dipyridamole infusion. There was also a significant difference between groups for Delta PSI (PSIpeak − PSIrest) and Delta PSE (PSEpeak − PSErest), respectively 126±145 vs −40±97, (p<0.01) and 108±163 vs −41±106 (p<0.01) Figure C. ROC analyses produced a statistically valid model: Average GLS at peak (p 0.001; AUC=0.906, cut-off value −18%, sensitivity 83% and specificity 82%); on the basis of these results, we compared WM and myocardial deformation analysis and GLS was superior to CFR LAD, Delta EF, Delta ESV and Delta WMI (Figure B). Conclusions GLS, PSE and PSI show an opposite response to dipyridamole, in patients with CAD in patient without CAD and show much higher sensitivity and specificity compared to the conventional parameters like WMI, EF and CFR in detecting CAD Funding Acknowledgement Type of funding source: None

Global Longitudinal Strain at Rest for Detection of Coronary Artery Disease in Patients without Diabetes Mellitus

2018 ◽  
Vol 38 (3) ◽  
pp. 413-421 ◽  
Author(s):  
Hou-juan Zuo ◽  
Xiu-ting Yang ◽  
Qi-gong Liu ◽  
Yan Zhang ◽  
He-song Zeng ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Longitudinal Strain ◽  
Global Longitudinal Strain ◽  
Artery Disease

scholarly journals Prevalence and Mortality of Hypochloremia Among Patients Suffering From Coronary Artery Disease and Congestive Heart Failure: An Analysis of Patients in CIN-I and MIMIC-III Databases

2021 ◽  
Vol 8 ◽  
Author(s):  
Haozhang Huang ◽  
Jin Liu ◽  
Yan Liang ◽  
Kunming Bao ◽  
Linfang Qiao ◽  
...  
Keyword(s):  
Heart Failure ◽  
Coronary Artery Disease ◽  
Congestive Heart Failure ◽  
Coronary Artery ◽  
Mortality Risk ◽  
Medical Information ◽  
Short Term ◽  
Artery Disease ◽  
Mimic Iii

Background: Hypochloremia is an independent predictor for mortality in patients with coronary artery disease (CAD) but whether the same correlation exists in CAD patients with congestive heart failure (CHF) is unclear.Methods: This is an analysis of data stored in the databases of the CIN-I [a registry of Cardiorenal Improvement (NCT04407936) in China from January 2007 to December 2018] and Medical Information Mart for Intensive Care (MIMIC)-III. CAD patients with CHF were included. The outcome measures were 90-day all-cause mortality (ACM) and long-term ACM.Results: Data from 8,243 CAD patients with CHF were analyzed. We found that 10.2% of the study population had hypochloremia (Cl− <98 mmol/L) in CIN-I (n = 4,762) and 20.1% had hypochloremia in MIMIC-III (n = 3,481). Patients suffering from hypochloremia were, in general, older and had a higher prevalence of comorbidities. After adjustment for confounders, hypochloremia remained a significant predictor of short-term mortality risk [90-day ACM: adjusted hazard ratio (aHR), 1.69; 95% CI, 1.27–2.25; P < 0.001 in CIN-I, and 1.36 (1.17–1.59); P < 0.001 in MIMIC-III]. Hypochloremia was also associated with long-term mortality [aHR, 1.26; 95% CI, 1.06–1.50; P = 0.009 in CIN-I, and 1.48 (1.32–1.66); P < 0.001 in MIMIC-III]. Prespecified subgroup analyses revealed an association of hypochloremia with long-term ACM to be attenuated slightly in the women of the two databases (P interaction < 0.05).Conclusions: Hypochloremia is independently associated with higher short-term and long-term ACM. Further studies are needed to determine if early preventive measurements and active intervention of hypochloremia can reduce the mortality risk of CAD patients with CHF.

scholarly journals Charms & Harms: Hawthorn

2011 ◽  
Vol 3 (1) ◽  
pp. 63 ◽  
Author(s):  
Phil Rasmussen
Keyword(s):  
Heart Failure ◽  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Herbal Medicines ◽  
Efficacy And Safety ◽  
Beneficial Effects ◽  
Large Numbers ◽  
Artery Disease ◽  
Long Term Studies

SUMMARY MESSAGE: Some evidence exists for hawthorn extracts having beneficial effects when taken concurrently with optimal medication for the treatment of mild chronic heart failure, although further long-term studies involving large numbers of patients are needed. Evidence is less convincing for its efficacy in hypertension, angina, coronary artery disease, arrhythmias and other cardiac conditions. As with all herbal medicines, different hawthorn products vary in their pharmaceutical quality, and the implications of this for dosage, efficacy and safety should be considered.

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