Enhanced removal of Cr(III)-EDTA chelates from high-salinity water by ternary complex formation on DETA functionalized magnetic carbon-based adsorbents

AbstractThe initial sensing of dietary methionine restriction (MR) occurs in the liver where it activates an integrated stress response (ISR) that quickly reduces methionine utilization. The ISR program is regulated in part by ATF4, but ATF4’s prototypical upstream regulator, eIF2α, is not acutely activated by MR. Bioinformatic analysis of RNAseq and metabolomics data from liver samples harvested 3 h and 6 h after initiating MR shows that general translation is inhibited at the level of ternary complex formation by an acute 50% reduction of hepatic methionine that limits formation of initiator methionine tRNA. The resulting ISR is induced by selective expression of ATF4 target genes that mediate adaptation to reduced methionine intake and return hepatic methionine to control levels within 4 days of starting the diet. Complementary in vitro experiments in HepG2 cells after knockdown of ATF4, or inhibition of mTOR or Erk1/2 support the conclusion that the early induction of genes by MR is partially dependent on ATF4 and regulated by both mTOR and Erk1/2. Taken together, these data show that initiation of dietary MR induces an mTOR- and Erk1/2-dependent stress response that is linked to ATF4 by the sharp, initial drop in hepatic methionine and resulting repression of translation pre-initiation.

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Ternary complex formation of the nickel(II), 2,2’-bipyridine, 1,10’-Phenanthroline and some aminoacids

Physics and Chemistry of Liquids ◽

10.1080/00319104.2021.1949011 ◽

2021 ◽

pp. 1-11

Author(s):

Yoselin Jara ◽

Mary Lorena Araujo ◽

Waleska Madden ◽

Vito Lubes ◽

Lino Hernández

Keyword(s):

Complex Formation ◽

Ternary Complex ◽

Ternary Complex Formation

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Sulfhydryl group modification of thymidylate synthetase and its effect on activity and ternary complex formation.

Journal of Biological Chemistry ◽

10.1016/s0021-9258(17)40041-x ◽

1977 ◽

Vol 252 (17) ◽

pp. 6139-6144 ◽

Cited By ~ 3

Author(s):

P C Plese ◽

R B Dunlap

Keyword(s):

Complex Formation ◽

Ternary Complex ◽

Sulfhydryl Group ◽

Thymidylate Synthetase ◽

Ternary Complex Formation ◽

Group Modification

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Structural determinants for binary and ternary complex formation between insulin-like growth factor-I (IGF-I) and IGF binding protein-3.

Journal of Biological Chemistry ◽

10.1016/s0021-9258(18)48458-x ◽

1992 ◽

Vol 267 (1) ◽

pp. 60-65

Author(s):

R C Baxter ◽

M L Bayne ◽

M A Cascieri

Keyword(s):

Growth Factor ◽

Complex Formation ◽

Ternary Complex ◽

Insulin Like Growth Factor ◽

Structural Determinants ◽

Factor I ◽

Ternary Complex Formation ◽

Igf I ◽

Igf Binding ◽

Igf Binding Protein

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The activity of eukaryotic initiation factor eIF-2 in ternary complex formation with GTP and Met-tRNA.

Journal of Biological Chemistry ◽

10.1016/s0021-9258(18)50744-4 ◽

1979 ◽

Vol 254 (9) ◽

pp. 3201-3205 ◽

Cited By ~ 2

Author(s):

R Benne ◽

H Amesz ◽

J W Hershey ◽

H O Voorma

Keyword(s):

Complex Formation ◽

Ternary Complex ◽

Initiation Factor ◽

Eukaryotic Initiation Factor ◽

Ternary Complex Formation

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Monthly Water Exchange through the Ryukyu Islands Revealed by Salinity Structural Changes

Advanced Materials Research ◽

10.4028/www.scientific.net/amr.864-867.2335 ◽

2013 ◽

Vol 864-867 ◽

pp. 2335-2339

Author(s):

Ya Pan Liu ◽

Jian Cheng Kang ◽

Jiong Zhu ◽

Qin Chen Han

Keyword(s):

Structural Changes ◽

Water Exchange ◽

High Salinity ◽

World Ocean ◽

Core Layer ◽

Ryukyu Islands ◽

High Salinity Water ◽

The Ryukyu Islands ◽

Salinity Water ◽

World Ocean Atlas

Using salinity database of World Ocean Atlas 2009 (WOA09) issued by NOAA in 2010, refer the range of high-salinity tongue to indicate the strength about high-salinity water, from the perspective of structural changes of salinity; the water exchange through Ryukyu Islands upper 500 m have been analyzed, the results show that: due to Ryukyu Trough, currents on both sides of Ryukyu Islands occur exchange, for upper 500 m, high-salinity water in east of the Ryukyu Islands mainly invade the west waterthe Kuroshio in East China Sea; the intrusion strength is powerful from the depth of 100 m to 200 m, and the 150 m layer is the core layer of high-salinity water intrusion; the high-salinity water at the east of Ryukyu Islands invades the Kuroshio are stronger in March, May, June, September, October and November, are weaker in April and December.

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