scholarly journals Randomized controlled comparative trial between low dose dexmedetomidine sedation and that of fentanyl in children after surgical procedures in surgical Pediatric Intensive Care Unit

2016 ◽  
Vol 32 (1) ◽  
pp. 137-142
Author(s):  
Riham Hussein Saleh
2005 ◽  
Vol 40 (11) ◽  
pp. 736-741 ◽  
Author(s):  
Ulrike Rapp-Bernhardt ◽  
Friedrich-Wilhelm Roehl ◽  
Rainer Esseling ◽  
Horst Lenzen ◽  
Manfred Schiborr ◽  
...  

Author(s):  
Haroldo Teófilo de Carvalho ◽  
José Roberto Fioretto ◽  
Rossano Cesar Bonatto ◽  
Cristiane Franco Ribeiro ◽  
Joelma Gonçalves Martin ◽  
...  

AbstractExtubation failure is a common event in intensive care units. Corticosteroids are effective in preventing failure in adults, but no consensus has been reached on this matter in pediatrics. We assessed the efficacy of intravenous dexamethasone in mechanically ventilated children and adolescents for more than 48 hours, with at least one risk factor for failure. Extubations were scheduled 24 hours in advance when possible, and patients were randomly assigned into two groups: one group received a loading dose followed by up to four doses of dexamethasone, and the other group received no corticosteroids. Need for reintubation and length of stay in the pediatric intensive care unit were similar in both groups, and frequency of reintubation was 12.9%.


2018 ◽  
Vol 49 (2) ◽  
pp. 148-153
Author(s):  
Gloria Lucía Lema Zuluaga ◽  
Mauricio Fenández Laverde ◽  
Ana Marverin Correa Varela ◽  
John Jairo Zuleta Tobón

Objective: To compare two endotracheal suctioning protocols according to morbidity, days of mechanical ventilation, length of stay in the Pediatric Intensive Care Unit (PICU), incidence of VentilatorAssociated Pneumonia (VAP) and mortality. Methods: A Pragmatic randomized controlled trial performed at University Hospital Pablo Tobón Uribe, Medellin-Colombia. Fortyfive children underwent an as-needed endotracheal suctioning protocol and forty five underwent a routine endotracheal suctioning protocol. Composite primary end point was the presence of hypoxemia, arrhythmias, accidental extubation and heart arrest. A logistic function trough generalized estimating equations (GEE) were used to calculate the Relative Risk for the main outcome. Results: Characteristics of patients were similar between groups. The composite primary end point was found in 22 (47%) of intervention group and 25 (55%) children of control group (RR= 0.84; 95% CI: 0.56-1.25), as well in 35 (5.8%) of 606 endotracheal suctioning performed to intervention group and 48(7.4%) of 649 performed to control group (OR= 0.80; 95% CI: 0.5-1.3). Conclusions: There were no differences between an as-needed and a routine endotracheal suctioning protocol. Trial Registration: ClinicalTrials.gov identifier: NCT01069185


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