Carotid intima-media thickness and neutrophil/lymphocyte ratio in patient with overt and subclinical hypothyroidism

2013 ◽  
Vol 24 ◽  
pp. e107
Author(s):  
F. Günes ◽  
M. Asık ◽  
B. Altun ◽  
H. Sen ◽  
E. Binnetoglu ◽  
...  
Keyword(s):  
Subclinical Hypothyroidism ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Neutrophil Lymphocyte Ratio ◽  
Lymphocyte Ratio ◽  
Media Thickness

Investigation of the arterial intima-media thickness in Behcet’s disease patients without vascular complaints

Vascular ◽  
2017 ◽  
Vol 26 (4) ◽  
pp. 356-361
Author(s):  
Nazım Kankilic ◽  
Aydın Aslan ◽  
Oguz Karahan ◽  
Sinan Demirtas ◽  
Ahmet Caliskan ◽  
...  
Keyword(s):  
Behçet’S Disease ◽  
Behcet’S Disease ◽  
Behçet's Disease ◽  
Intima Media Thickness ◽  
Vascular Involvement ◽  
Behcet's Disease ◽  
Neutrophil Lymphocyte Ratio ◽  
Lymphocyte Ratio ◽  
Media Thickness ◽  
Arterial Intima

Objectives Behcet’s disease is a multisystemic, inflammatory disease. Various factors have been implicated in the disease, including genetics, infections, immunoglobulins, immune complexes, antibodies, and oxidative stress. However, the underlying etiopathogenesis remains unclear. Behcet’s disease can occur with or without vascular involvement. This prospective study investigated the relationship between the intima-media thickness of the major arteries, in addition to other factors affecting the disease process, in Behcet’s disease without vascular involvement. Methods Twenty-four patients (average age: 38.50 ± 10.931) without vascular involvement or any vascular complaints who were diagnosed with Behcet’s disease were included in the study. Sixteen healthy subjects (average age: 39.75 ± 7.793) were included as a control group. Demographic information and medical histories were recorded, and routine blood tests were performed in both groups. The intima-media thickness of the subclavian, axillary, femoral, and carotid arteries of all the participants were recorded using Doppler ultrasonography. The data were then subjected to intergroup statistical and correlation analyses. Results There were no significant differences between the arterial intima-media thickness values of the Behcet’s disease patients and those of the control group ( p > 0.05). However, there was a significant difference between the neutrophil–lymphocyte ratio ( p = 0.004), low-density lipoprotein ( p = 0.007), and triglyceride ( p = 0042) levels of the two groups. Significant correlations were found between intima-media thickness and neutrophil–lymphocyte ratio levels ( p = 0.012) and the disease duration ( p = 0.030). There was also a significant correlation between the intima-media thickness of the femoral artery and disease duration ( p = 0.014). Conclusions The results showed that the duration of illness had a significant effect on arterial intima-media thickness in Behcet’s disease. Blood neutrophil–lymphocyte ratio levels were also associated with increased intima-media thickness.

scholarly journals The Correlation between Carotid Intima-Media Thickness and Neutrophil to Lymphocyte Ratio in Prediabetes Patients

2021 ◽  
Vol 42 (6) ◽  
pp. 464-470
Author(s):  
Dayoung Lee ◽  
Mi-Jeong Park ◽  
Mee Young Kim ◽  
Jung Jin Cho ◽  
Jong Lull Yoon
Keyword(s):  
Regression Analysis ◽  
Binary Logistic Regression ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Neutrophil To Lymphocyte Ratio ◽  
Binary Logistic Regression Analysis ◽  
Diabetic Patients ◽  
Cvd Risk ◽  
Lymphocyte Ratio ◽  
Media Thickness

Background: Prediabetes is a metabolic state between normoglycemia and diabetes and is known to carry a higher risk of developing overt diabetes and cardiovascular disease (CVD). The relative and absolute risks of all-cause mortality, CVD, coronary heart disease, and stroke in prediabetes patients, as well as in diabetic patients, is higher than that in patients with normoglycemia. Carotid intima-media thickness (cIMT) is a method used to stratify CVD risk. In this study, we aimed to determine whether the neutrophil-to-lymphocyte ratio (NLR) correlates with cIMT in prediabetes patients.Methods: From January 1, 2016, to February 20, 2021, 581 adults their 30s–70s who underwent carotid ultrasonography as part of a comprehensive medical examination at the Dongtan Sacred Heart Hospital were enrolled. Statistical analysis using SPSS presented t-test and chi-square test significance levels into a group with normal cIMT (nIMT; cIMT <1 mm) and a group with thick cIMT (tIMT; cIMT ≥1 mm). Binary logistic regression analysis was performed to confirm the correlation between NLR and cIMT.Results: In prediabetic adults, age, hemoglobin A1c (HbA1c), systolic blood pressure, and NLR were significantly higher in the tIMT group than in the nIMT group. In the regression analysis, NLR, age, and HbA1c were significantly correlated with cIMT.Conclusion: NLR was significantly higher in the tIMT group than in the nIMT group; therefore, NLR may be used to assess CVD risk in prediabetes patients.

Abstract 111: Effect of Thyroxin Treatment on Carotid Intima Media Thickness (CIMT) Reduction in Patients With Subclinical Hypothyroidism (SCH)-A Meta-Analysis of Randomized Clinical Trials

2017 ◽  
Vol 37 (suppl_1) ◽  
Author(s):  
Yugandhar Kandimalla ◽  
Muhammad Aziz ◽  
Archana Machavarapu ◽  
Rehan Malik ◽  
Adnan Younus ◽  
...  
Keyword(s):  
Clinical Trials ◽  
Subclinical Hypothyroidism ◽  
Randomized Clinical Trials ◽  
Meta Analysis ◽  
Hormone Replacement ◽  
Surrogate Marker ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Post Treatment ◽  
Media Thickness

Background: Research shows that subclinical hypothyroidism (SCH) is related to increased carotid intima media thickness (CIMT), a surrogate marker of stroke and subclinical cardiovascular disease (CVD). It is controversial whether SCH should be treated or not to reduce risk of stroke and CVD morbidity and mortality. The aim of this meta-analysis was to determine whether SCH is associated with an increase in CIMT as compared to Euthyroidism (EU) and whether thyroxin therapy in SCH can reverse the change in CIMT. Methods: Two independent reviewers did an extensive database search up to December 2016. Total of 12 randomized clinical trials discussed effect of thyroxin treatment on CIMT values at pre-and-post treatment in SCH subjects. Results: CIMT was significantly higher among SCH (n=280) as compared to EU controls (n=263) at baseline, pooled standardized mean difference (SMD) of CIMT was 0.44 mm [95%CI 0.14, 0.74], SE=0.15; p=0.004 with heterogeneity I 2 = 65%. After treatment with thyroxin in SCH subjects (n=314), there was a statistically significant decrease in CIMT from pre-to-post treatment, pooled SMD of CIMT decrease was [SMD -0.32; 95%CI (-0.47, -0.16), SE=0.08; p<0.0001, with heterogeneity I 2 = 2%], and was no longer different from EU controls [SMD 0.13 mm; 95% CI (-0.04, 0.30); p= 0.14; I 2 = 27%]. The total cholesterol, triglycerides, and low density lipoprotein were higher in SCH as compared to EU controls and decreased significantly after treatment with thyroxin. Conclusion: This meta-analysis shows that thyroxin therapy in SCH subjects significantly decreases CIMT and improves lipid profile, modifiable risk factors for stroke and CVD. Thyroid hormone replacement in SCH subjects might have a role in slowing down or preventing progression of atherosclerosis.

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