Physico-chemical characterization of disoxaril–dimethyl-β-cyclodextrin inclusion complex and in vitro permeation studies

2006 ◽  
Vol 41 (2) ◽  
pp. 233-240 ◽  
Author(s):  
Cinzia Anna Ventura ◽  
Ignazio Giannone ◽  
Teresa Musumeci ◽  
Rosario Pignatello ◽  
Lorella Ragni ◽  
...  
Keyword(s):  
Inclusion Complex ◽  
Chemical Characterization ◽  
Cyclodextrin Inclusion ◽  
Physico Chemical ◽  
In Vitro Permeation ◽  
Permeation Studies ◽  
Cyclodextrin Inclusion Complex

Characterization of a new TiF4 and β-cyclodextrin inclusion complex and its in vitro evaluation on inhibiting enamel demineralization

2013 ◽  
Vol 58 (3) ◽  
pp. 239-247 ◽  
Author(s):  
Camila Nassur ◽  
Adílis Kalina Alexandria ◽  
Luciana Pomarico ◽  
Valeria Pereira de Sousa ◽  
Lúcio Mendes Cabral ◽  
...  
Keyword(s):  
Inclusion Complex ◽  
In Vitro Evaluation ◽  
Enamel Demineralization ◽  
Cyclodextrin Inclusion ◽  
Cyclodextrin Inclusion Complex

Preparation of celecoxib-dimethyl-β-cyclodextrin inclusion complex: characterization and in vitro permeation study

2005 ◽  
Vol 40 (7) ◽  
pp. 624-631 ◽  
Author(s):  
Cinzia Anna Ventura ◽  
Ignazio Giannone ◽  
Donatella Paolino ◽  
Venerando Pistarà ◽  
Antonino Corsaro ◽  
...  
Keyword(s):  
Inclusion Complex ◽  
Cyclodextrin Inclusion ◽  
Permeation Study ◽  
In Vitro Permeation ◽  
Complex Characterization ◽  
Cyclodextrin Inclusion Complex

scholarly journals Development, stability and in vitro permeation studies of gels containing mometasone furoate for the treatment of dermatitis of the scalp

2010 ◽  
Vol 46 (1) ◽  
pp. 109-114 ◽  
Author(s):  
Ana Cristina Gomes Barros Salgado ◽  
Alexandra Maria Nunes Nogueira da Silva ◽  
Marta Cristina Jorge Cabral Machado ◽  
Maria Aida da Silva Costa Duarte ◽  
Helena Margarida de Oliveira Marques Ribeiro
Keyword(s):  
Inflammatory Diseases ◽  
Chemical Characterization ◽  
Mometasone Furoate ◽  
Suitable Alternative ◽  
In Vitro Permeation ◽  
Permeation Studies ◽  
Development Stability ◽  
Microbiological Properties

Dermatological inflammatory diseases such as atopic dermatitis, psoriasis and seborrhoeic dermatitis often affect the scalp and the eyebrows. Although there are many dosage forms available, these are particularly critical anatomic regions for application of topical formulations because of the presence of hair. Lotions are therefore the recommended type of drug delivery system for these areas. The presence of hair may limit the application and thus the acceptability of the formulation and its compliance. Because of its low apparent viscosity, lotion application is unpleasant. Gels, given their consistency and adhesiveness, are a suitable alternative to lotions in this situation. The aim of this study was to formulate a stable gel containing mometasone furoate, which is an anti-inflammatory and anti-pruritic corticosteroid, in order to improve topical treatment of scalp dermatitis. In this study, pharmaceutical development, physical-chemical characterization, stability and in vitro permeation studies were performed. In terms of the pH, viscosity, assay and macroscopic and microbiological properties, the gel was stable over the period of study. The in vitro permeation studies allowed the characterization of the mometasone furoate permeation profile for the gel through different membranes. Mometasone furoate presented a slow permeation through the skin. This gel appears safe for topical application.

BEHAVIOURAL STUDY OF CYCLODEXTRIN INCLUSION COMPLEX ON ENHANCEMENT OF SOLUBILITY OF ACECLOFENAC

INDIAN DRUGS ◽  
2015 ◽  
Vol 52 (11) ◽  
pp. 19-23
Author(s):  
J Shaikh ◽  
◽  
S. V. Deshmane ◽  
R. N Purohit ◽  
K. R. Biyani
Keyword(s):  
Inclusion Complex ◽  
Solid Dispersion ◽  
Water Soluble ◽  
In Vitro Dissolution ◽  
Phase Solubility ◽  
Solubility Study ◽  
Cyclodextrin Inclusion ◽  
Poorly Water Soluble ◽  
Cyclodextrin Inclusion Complex

The main objective of the present study was to enhance the solubility and dissolution rate of poorly water soluble aceclofenac using its solid dispersion with β-cyclodextrin. FTIR and DSC study was carried out to find out any incompatibility. The phase solubility of drug was carried out in 1, 2, 5, and 10% of β-cyclodextrin in distilled water. Kneading method and solvent evaporation method was use to prepared solid dispersion of aceclofenac and β-cyclodextrin. Different evaluation tests like solubility study in different solvents, PXRD and in vitro dissolution study of aceclofenac- β-cyclodextrin inclusion complex were carried out. The overall finding indicated that β-cyclodextrin is a desirable water soluble carrier, that helps in increasing solubility of drug. Due to its structural feature, β-cyclodextrin forms a good inclusion complex that decreases contact angle of drug with water molecules by increasing wetting properties. Hence, it can be concluded that, β-cyclodextrin is better water soluble carrier molecule in terms of its compatibility and increasing solubility behavior of poorly water soluble drug aceclofenac.

scholarly journals Characterization of nimodipine/β-cyclodextrin inclusion complex

1998 ◽  
Vol 50 (S9) ◽  
pp. 180-180 ◽  
Author(s):  
Irena Homšek ◽  
Branko Kolarić ◽  
Slavica Ristić ◽  
Ivana Kolarić
Keyword(s):  
Inclusion Complex ◽  
Cyclodextrin Inclusion ◽  
Cyclodextrin Inclusion Complex

scholarly journals Delineating the behavior of Berberis anthocyanin/β-cyclodextrin inclusion complex in vitro: A molecular dynamics approach

LWT ◽  
2022 ◽  
pp. 113090
Author(s):  
Prakash Chandra Pradhan ◽  
Abhishek Mandal ◽  
Anirban Dutta ◽  
Rohan Sarkar ◽  
Aditi Kundu ◽  
...  
Keyword(s):  
Molecular Dynamics ◽  
Inclusion Complex ◽  
Cyclodextrin Inclusion ◽  
Cyclodextrin Inclusion Complex
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