Instability of socio-economic and sustainable development of Ural regions

Problems of development stability of regional economies are of particular importance in current conditions. The article presents the analysis of the sustainability of the development of Russian regions included in one of the most industrially developed federal districts - the Ural. The study used data from Rosstat for 2001-2019. The tendencies of the instability of indicators of socio-economic development of regions are revealed: gross regional product, investments in fixed assets, industrial production, and consumer prices. It has been established that the dynamics of the growth rates of these indicators are volatile. At the same time, all trends demonstrate a reasonably rapid recovery after the external shocks of 2008 and 2014. These indicators’ volatility was assessed using the variation coefficient in three different periods: 2001-2008, 2010-2014, and 2015-2019. The conclusion is made about the high instability of regional socio-economic development, while the level of instability in regions with a lower level of development turned out to be higher than in more developed ones. Particular attention is paid to trends in the level of instability, and it is noted that over time, less developed regions increase instability at a faster pace.

Political Security in Southern Africa: Historical, Contemporary and Futuristic Perspectives

Political security has been widely argued to be one of the fundamental pillars of development, stability and prosperity, as it in turn lays the ground and conducive environment for the attainment of other forms of human security, namely economic security, food security, health security, environmental security, personal security and community security. Political security, as stated by the United Nations Human Development Report (994), entails defense against the different forms of political oppression, respect to human rights, and protection from threats of militarization. Therefore, the purpose of this paper was to establish the extent towhich the concept of Political Security is applicable in Southern Africa within the context of a fast-globalizing landscape through analyzing historical and contemporary trends as well as forecasting future trends and patterns of political security in Southern Africa. Methodologically, the paper used secondary data sources to examine historical and contemporary trends in political security within Southern African countries whilst the International Futures (IFs) model, a comprehensive integrated modeling system, was used as a forecasting tool to establish the likelihood of political security within the different Southern African countries and future political security dynamics and complexities within Southern African countries whilst at the same timeproviding an outlook of the situation within the next 12 years. The study results show varying levels of political security in the region, with the majority of the Southern African states showing worsening political security situation by 2030, except Mauritius, Botswana, Namibia, Seychelles, and South Africa. Recommendations are suggested in the form of national and regional policy and strategic interventions that are key in strengthening political security within Southern Africa.

Fluctuating Asymmetry as a Method of Assessing Environmental Stress in Two Predatory Carabid Species within Mediterranean Agroecosystems

Fluctuating asymmetry (FA) is used in assessing the effect of environmental stress on the development stability of individuals by measuring small random deviations from perfect bilateral symmetry. Here, we checked for FA on two predatory carabid beetles, Pterostichus melas and Poecilus koyi, in order to evaluate species response to agricultural practices within Mediterranean agroecosystems, as well as FA as a method. The samples were collected in vineyards and olive groves, both under integrated pest management (IPM) and ecological pest management (EPM), and in pristine habitats in the Mediterranean region of Croatia. Geometric morphometrics (GMMs) were used to analyze the pronotum and abdomen shape variations and left–right asymmetries of each population. In respect to the FA measurements, analyzed species responded differently, with P. koyi displaying a lower intensity of FA than P. melas. On the other hand, P. melas beetles from vineyards showed a higher intensity of FA compared with populations from pristine habitats and olive groves. Accordingly, FA pointed out olive groves as potentially less adverse habitats to predatory carabids, keeping in mind the different levels of asymmetry between the two species. Our study singled out P.melas as a more suitable species for further research, in the effect that different agricultural practices can have their impact on non-target invertebrates analyzed by measuring the FA.

The Role of α1-Microglobulin (A1M) in Erythropoiesis and Erythrocyte Homeostasis—Therapeutic Opportunities in Hemolytic Conditions

α1-microglobulin (A1M) is a small protein present in vertebrates including humans. It has several physiologically relevant properties, including binding of heme and radicals as well as enzymatic reduction, that are used in the protection of cells and tissue. Research has revealed that A1M can ameliorate heme and ROS-induced injuries in cell cultures, organs, explants and animal models. Recently, it was shown that A1M could reduce hemolysis in vitro, observed with several different types of insults and sources of RBCs. In addition, in a recently published study, it was observed that mice lacking A1M (A1M-KO) developed a macrocytic anemia phenotype. Altogether, this suggests that A1M may have a role in RBC development, stability and turnover. This opens up the possibility of utilizing A1M for therapeutic purposes in pathological conditions involving erythropoietic and hemolytic abnormalities. Here, we provide an overview of A1M and its potential therapeutic effect in the context of the following erythropoietic and hemolytic conditions: Diamond-Blackfan anemia (DBA), 5q-minus myelodysplastic syndrome (5q-MDS), blood transfusions (including storage), intraventricular hemorrhage (IVH), preeclampsia (PE) and atherosclerosis.

The Gut Microbiome as a Component of the Gut–Brain Axis in Cognitive Health

Introduction: The human microbiome, the microorganisms living in and on the body, plays a vital role in brain physiology and pathophysiology. The gut microbiome (GMB) has been identified as a link in the gut–brain axis moderating cognitive development and health. Objectives: The objectives of this scoping review are to discuss mechanisms of the microbiome–gut–brain axis in cognition, review the existing literature on the GMB and cognition, and discuss implications for nursing research. Methods: We searched Pubmed using the terms “gut microbiome,” “brain,” and “cognition” and the terms “gut brain axis,” “microbiome,” and “cognition”; removed duplicates, studies not published in English, and unrelated publications; and added additional articles identified through references. We retained the 85 most relevant publications for this review. Results: Common themes in the current literature include GMB components; interactions on cognitive development; effects of GMB–gut–brain interactions on cognition, mild cognitive impairment and Alzheimer’s disease; effects of GMB interactions with physiologic stress on cognition in critical care; and GMB modification for improved cognition. Review of the literature on each of these topics reveals multiple theoretical mechanisms of action for GMB–gut–brain interaction that modify cognitive development and function across the lifespan. Discussion: GMB components and dysbiosis have been implicated in many cognitive states, and specific microbiota constituents contribute to cognitive development, stability, and impairment. The study of these interactions is relevant to nursing research as it addresses the holistic human experience and microbiome constituents are modifiable, facilitating translation into the clinical setting.