Cytotoxic copper (II) mixed ligand complexes: Crystal structure and DNA cleavage activity

2011 ◽  
Vol 46 (9) ◽  
pp. 4537-4547 ◽  
Author(s):  
Verasuntharam M. Manikandamathavan ◽  
Royapuram P. Parameswari ◽  
Thomas Weyhermüller ◽  
Hannah R. Vasanthi ◽  
Balachandran Unni Nair
Keyword(s):  
Crystal Structure ◽  
Dna Cleavage ◽  
Mixed Ligand ◽  
Mixed Ligand Complexes ◽  
Cleavage Activity ◽  
Dna Cleavage Activity

scholarly journals Synthesis, characterization and DNA cleavage activity of nickel(II) adducts with aromatic heterocyclic bases

2010 ◽  
Vol 75 (1) ◽  
pp. 61-74 ◽  
Author(s):  
Surendra Babu ◽  
Pitchika Krishna ◽  
Hussain Reddy ◽  
G.H. Philip
Keyword(s):  
Dna Cleavage ◽  
Magnetic Moments ◽  
Nuclease Activity ◽  
Mixed Ligand ◽  
Mixed Ligand Complexes ◽  
Cleavage Activity ◽  
Redox Couples ◽  
Dna Cleavage Activity ◽  
Calf Thymus ◽  
Heterocyclic Bases

Mixed ligand complexes of nickel(II) with 2,4-dihydroxyacetophenone oxime (DAPO) and 2,4-dihydroxybenzophenone oxime (DBPO) as primary ligands, and pyridine (Py) and imidazole (Im) as secondary ligands were synthesized and characterized by molar conductivity, magnetic moments measurements, as well as by electronic, IR, and 1H-NMR spectroscopy. Electrochemical studies were performed by cyclic voltammetry. The active signals are assignable to the NiIII/II and NiII/I redox couples. The binding interactions between the metal complexes and calf thymus DNA were investigated by absorption and thermal denaturation. The cleavage activity of the complexes was determined using double-stranded pBR322 circular plasmid DNA by gel electrophoresis. All complexes showed increased nuclease activity in the presence of the oxidant H2O2. The nuclease activities of mixed ligand complexes were compared with those of the parent copper(II) complexes.

Synthesis, crystal structure, magnetic property and DNA cleavage activity of a new terephthalate-bridged tetranuclear copper(II) complex

Polyhedron ◽  
2007 ◽  
Vol 26 (15) ◽  
pp. 4509-4517 ◽  
Author(s):  
Koushik Dhara ◽  
Partha Roy ◽  
Jagnyeswar Ratha ◽  
Mario Manassero ◽  
Pradyot Banerjee
Keyword(s):  
Crystal Structure ◽  
Magnetic Property ◽  
Dna Cleavage ◽  
Cleavage Activity ◽  
Dna Cleavage Activity

Synthesis, crystal structure and DNA cleavage activity of a novel Ni(II)–Cd(II) coordination polymer

2009 ◽  
Vol 362 (4) ◽  
pp. 1109-1114 ◽  
Author(s):  
De-Ming Kong ◽  
Li-Na Zhu ◽  
Jiao Wang ◽  
Ya-Wei Jin ◽  
Xiao-Zeng Li ◽  
...  
Keyword(s):  
Crystal Structure ◽  
Coordination Polymer ◽  
Dna Cleavage ◽  
Cleavage Activity ◽  
Dna Cleavage Activity

Synthesis and Characterisation of RuII Polypyridyl Complexes: DNA-Binding, Photocleavage, and Topoisomerase I and II Inhibitory Activity

2013 ◽  
Vol 66 (11) ◽  
pp. 1406 ◽  
Author(s):  
Xiaojun He ◽  
Guang Yang ◽  
Xiaonan Sun ◽  
Lingjun Xie ◽  
Lifeng Tan
Keyword(s):  
Dna Binding ◽  
Dna Cleavage ◽  
Topoisomerase I ◽  
Mixed Ligand ◽  
Dual Inhibitor ◽  
Cleavage Activity ◽  
Dna Cleavage Activity ◽  
Pbr322 Dna ◽  
Dna Strand ◽  
Strand Passage

Two mixed-ligand ruthenium(ii) complexes [Ru(phen)2(cptcp)]2+ (Ru1; phen = 1,10-phenanthroline, cptcp = 2-(4-carbazol-9-yl-phenyl)-1H-1,3,7,8-tetraaza-cyclopenta-[l]-phenanthrene) and [Ru(phen)2(btcpc)]2+ (Ru2; btcpc = 9-butyl-6-(1H-1,3,7,8-tetraaza-cyclo-cyclopenta-[l]-phenanthren-2-yl)-9H-carbazole-3-carbaldehyde) have been synthesised and characterised. The DNA-binding behaviours of the two complexes have been investigated by using spectroscopic and viscosity measurements. Results suggest that the two complexes bind to DNA by intercalation. The photocleavage of plasmid pBR322 DNA indicates that Ru1 exhibits more effective DNA cleavage activity in comparison to that exhibited by Ru2 under the same conditions, and different cleavage mechanisms are determined. Topoisomerase inhibition and DNA strand passage assay confirm that Ru1 may act as an efficient dual inhibitor of topoisomerases I and II, whereas Ru2 may only act as a single inhibitor of topoisomerases II.

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