Synthesis, anti-inflammatory activity and molecular docking studies of 2,5-diarylfuran amino acid derivatives

2012 ◽  
Vol 47 ◽  
pp. 52-58 ◽  
Author(s):  
Hélio A. Stefani ◽  
Giancarlo V. Botteselle ◽  
Julio Zukerman-Schpector ◽  
Ignez Caracelli ◽  
Denis da Silva Corrêa ◽  
...  
Keyword(s):  
Molecular Docking ◽  
Amino Acid ◽  
Docking Studies ◽  
Inflammatory Activity ◽  
Amino Acid Derivatives ◽  
Molecular Docking Studies ◽  
Anti Inflammatory

Synthesis of sulpha drug based hydroxytriazene derivatives: Anti-diabetic, antioxidant, anti-inflammatory activity and their molecular docking studies

2020 ◽  
Vol 96 ◽  
pp. 103642 ◽  
Author(s):  
Poonam Sharma ◽  
Varsha Dayma ◽  
Aparna Dwivedi ◽  
Prabhat K. Baroliya ◽  
I.P. Tripathi ◽  
...  
Keyword(s):  
Molecular Docking ◽  
Docking Studies ◽  
Inflammatory Activity ◽  
Molecular Docking Studies ◽  
Sulpha Drug ◽  
Anti Inflammatory

Synthesis, anti‐inflammatory activity, and molecular docking studies of some novel Mannich bases of the 1,3,4‐oxadiazole‐2(3 H )‐thione scaffold

2020 ◽  
Vol 353 (7) ◽  
pp. 2000061
Author(s):  
Tugce Ozyazici ◽  
Enise E. Gurdal ◽  
Duygu Orak ◽  
Hande Sipahi ◽  
Tuba Ercetin ◽  
...  
Keyword(s):  
Molecular Docking ◽  
Mannich Bases ◽  
Docking Studies ◽  
Inflammatory Activity ◽  
Molecular Docking Studies ◽  
Anti Inflammatory

scholarly journals Anti-inflammatory activity and molecular docking studies of quinolyl-thienyl chalcone

2016 ◽  
Vol 11 (3) ◽  
pp. 703 ◽  
Author(s):  
Nasiara Karim ◽  
Rahat Ullah ◽  
Imran Khan ◽  
Muslim Raza ◽  
Abdur Rauf ◽  
...  
Keyword(s):  
Molecular Docking ◽  
Docking Studies ◽  
Inflammatory Activity ◽  
Molecular Docking Studies ◽  
Anti Inflammatory

scholarly journals Molecular Docking Studies, Synthesis, Toxicological Evaluation using Brine Shrimp (Artemia salina L.) Model and Anti-inflammatory Activity of Some N-(substituted)-5-phenyl-1,3,4-thiadiazol-2-amine Derivatives

2020 ◽  
pp. 51-62
Author(s):  
Mayuri V. Bhosale ◽  
Akshay R. Yadav ◽  
Chandrakant S. Magdum ◽  
Shrinivas K. Mohite
Keyword(s):  
Molecular Docking ◽  
Brine Shrimp ◽  
Protein Denaturation ◽  
Artemia Salina ◽  
Docking Studies ◽  
Inflammatory Activity ◽  
Binding Motif ◽  
Toxicological Evaluation ◽  
Molecular Docking Studies ◽  
Anti Inflammatory

A series of new N-(substituted)-5-phenyl-1,3,4-thiadiazol-2-amine derivatives were synthesized under microwave irradiation and evaluated for their anti-inflammatory activity and in-silico (molecular docking studies) to recognize the hypothetical binding motif of the title compounds using VLifeMDS software. The binding mode of the title compounds has been proposed based on the docking studies. They have interesting pharmacophore that display a broad spectrum of biological activity. The 1,3,4-thiadiazole scaffold is an interesting building block that has been used to synthesize a variety of useful bioactive compounds. The present studies widen the scope of the brine shrimp model that may prove quite helpful as a preliminary screen to determine toxic properties. In Brine shrimp lethality bioassay, compounds produced dose dependent cytotoxicity effect to brine shrimp nauplii. Inflammation is a complex process, which is frequently associated with pain and involves occurrences such as the increase of vascular permeability, increase of protein denaturation, and membrane alteration. The pharmacological evaluation of 1,3,4-thiadiazole derivatives revealed that, among all the compounds screened compound code 3c were found to have promising anti-inflammatory activity.

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