Acetazolamid orális alkalmazása mellett jelentkező chorioidealeválás két esete: ismert idioszinkráziás hatás szokatlan megjelenési formája?

Sulpha drugs are widely employed in medicine for various diseases and disorders. During the last several decades, numerous papers had been published on supra ciliary and posterior choroidal effusion likely presenting as an idiosyncratic effect of these drugs especially of acetazolamide. In each publication, the effusion was associated with either an acute angle-closure glaucoma or transitory myopia or both of these as leading symptoms. In the current publication, authors report on two cases where the acetazolamide-induced choroidal effusion was an accidental finding without either a myopic shift in refraction or an acute elevation in intraocular pressure. To our best knowledge, ours is the first report in the literature describing this unusual, “silent” form of a sulpha drug-induced choroidal effusion. Since the choroidal involvement may vary in size and location, and is not necessarily associated with acute glaucoma and myopia, one can assume that a considerable amount of acetazolamide-related ocular side-effects will not be discovered. The above case report aims to draw the attention of other specialities to the need for ophthalmic examination for their patients taking sulpha drugs with acute visual deterioration. Orv Hetil. 2017; 158(50): 1998–2002.

Effect of Trimethoprim on Glycogen Contents in Freshwater Mussels, Lamellidens corrianus (Lea) & Parreysia cylindrica (Annandale & Prashad)

Freshwater bivalves, Lamellidens corrianus were exposed to acute dose of trimethoprim one of the ingredients of sulpha drug (174.80PPM) and Parreysia cylindrica (136.29PPM) up to 96 hours and chronic dose to Lamellidens corrianus of the same antibiotics (34.96 PPM) and to Parreysia cylindrica was (27.25 PPM) up to 21 days. After 24 and 96 hours of acute treatment and 7, 14 and 21 days of chronic treatment, the mantle, gills, foot, ovary, testis, digestive glands and whole body of the bivalves were separated, dried in the oven and their glycogen contents were estimated.Except gills, trimethoprim reduced the glycogen contents from most of the tissues of L. corrianus while in Parreysia cylindrica overall reduction in the glycogen depot was observed. The most affected tissue in which the great depletion observed was digestive glands.DOI: http://dx.doi.org/10.3126/ijls.v6i1.5767

Synthesis, Spectroscopic Characterization and Theoretical Study of Schiff Bases Derived from Phenylsulfonylamide

The synthesis, characterization, and theoretical study of two Schiff bases of ligands derived from condensation of sulphoacetamide sodium with 4-methoxy benzaldehyde and salicalaldehyde arereported. Spectroscopic techniques, including IR, UV, 1H NMR, and CHN analysis were used to identify the product. The calculated HOMO is largely localized on the N-benzylideneaniline fragment, while the calculated LUMO of the studied molecule is seen to be substantially localized along the C–C axis of the conjugated system. Keyword: Sulphoacetamide sodium complex; Schiff bases; Sulpha drug; Semi-empirical (PM3) methods. © 2009 JSR Publications. ISSN: 2070-0237 (Print); 2070-0245 (Online). All rights reserved. DOI: 10.3329/jsr.v1i3.2589 J. Sci. Res. 1 (3), 563-568 (2009)

Voltammetric and potentiometric studies of some sulpha drug-Schiff base compounds and their metal complexes

The electrochemical behavior of some sulpha drug-Schiff bases at a mercury electrode was examined in the Britton-Robinson universal buffer of various pH values (2.5–11.7) containing 20% v/v) of ethanol using DC-polarography, cyclic voltammetry and controlled-potential electrolysis. The DC-polarograms and cyclic voltammograms of the examined compounds exhibited a single, 2-electron, irreversible, diffusion-controlled cathodic step within the entire pH range which is attributed to the reduction of the azomethine group-CH=N- to -CH2-NH-. The symmetry transfer coefficient (α) of the electrode reaction and the diffusion coefficient (D 0) of the reactant species were determined. The electrode reaction pathway of the compounds at the mercury electrode was suggested to follow the sequence: H+, e−, e−, H+. The dissociation constant of the sulpha drug-Schiff bases, the stability constant and stoichiometry of their complexes with various divalent transition metal ions (Mn2+, Co2+, Ni2+, Cu2+ and Zn2+) were determined potentiometrically at room temperature.

Large scale molecular dynamics simulation of native and mutant dihydropteroate synthase–sulphanilamide complexes suggests the molecular basis for dihydropteroate synthase drug resistance

Antibiotic resistance is hampering the efficacy of drugs in the treatment of several pathological infections. Dihydropteroate synthase (DHPS) has been targeted by sulphonamide inhibitors for the past 60 years and has developed different amino acid mutations to survive sulpha drug action. We couple homology modelling techniques and massively parallel molecular dynamics simulations to study both the drug-bound and apo forms of native and mutant DHPS. Simulations of the complex between sulphanilamide and Streptomyces pneumoniae , DHPS shows how sulphanilamide is able to position itself close to 6-hydroxymethyl-7, 8-dihydropteridine-phosphate in a suitable position for the enzymatic transformation whereas in the mutant complex the sulpha drug is expelled from the catalytic site. Our simulations, therefore, provide insight into the molecular basis for drug resistance with S. pneumoniae DHPS.