Designing, structural elucidation, comparison of DNA binding, cleavage, radical scavenging activity and anticancer activity of copper(I) complex with 5-dimethyl-2-phenyl-4-[(pyridin-2-ylmethylene)-amino]-1,2-dihydro-pyrazol-3-one Schiff base ligand

2013 ◽  
Vol 64 ◽  
pp. 81-89 ◽  
Author(s):  
Subbaiyan Sathiyaraj ◽  
Krishnan Sampath ◽  
Ray J. Butcher ◽  
Raghavaiah Pallepogu ◽  
Chinnasamy Jayabalakrishnan
Keyword(s):  
Schiff Base ◽  
Dna Binding ◽  
Anticancer Activity ◽  
Schiff Base Ligand ◽  
Radical Scavenging Activity ◽  
Radical Scavenging ◽  
Structural Elucidation ◽  
Scavenging Activity

Natural dibenzoxazepinones from leaves of Carex distachya: Structural elucidation and radical scavenging activity

2007 ◽  
Vol 17 (3) ◽  
pp. 636-639 ◽  
Author(s):  
Antonio Fiorentino ◽  
Brigida D’Abrosca ◽  
Severina Pacifico ◽  
Giuseppe Cefarelli ◽  
Piera Uzzo ◽  
...  
Keyword(s):  
Radical Scavenging Activity ◽  
Radical Scavenging ◽  
Structural Elucidation ◽  
Scavenging Activity

scholarly journals Investigation of Antimicrobial, Antioxidant, and DNA Binding Studies of Bioactive Cu(II), Zn(II), Co(II), and Ni(II) Complexes of Pyrimidine Derivative Schiff Base Ligand

2017 ◽  
Vol 2017 ◽  
pp. 1-8 ◽  
Author(s):  
Shahul Hameed Sukkur Saleem ◽  
Murugesan Sankarganesh ◽  
Paul Raj Adwin Jose ◽  
Karunganathan Sakthikumar ◽  
Liviu Mitu ◽  
...  
Keyword(s):  
Schiff Base ◽  
Dna Binding ◽  
Schiff Base Ligand ◽  
Dna Cleavage ◽  
Radical Scavenging ◽  
Antioxidant Property ◽  
Antimicrobial Activities ◽  
Pyrimidine Derivative ◽  
Planar Geometry ◽  
Binding Studies

A new pyrimidine based Schiff base ligand (HL) and its four complexes of type [MLOAc]·nH2O (Cu(II), 1; Zn(II), 2; Co(II), 3; and Ni(II), 4) have been synthesized and characterized by elemental analysis, MS, 1H-NMR, FT-IR, UV-visible, and ESR techniques. The electronic and ESR spectral data suggested that complexes 1–4 possess square planar geometry. Antimicrobial activities of HL and complexes 1–4 were tested against four bacteria (Staphylococcus aureus, Staphylococcus pneumonia, Salmonella enterica typhi, and Haemophilus influenzae) and two fungal strains (Aspergillus flavus and Aspergillus niger). These results show that complexes 1–4 have good antimicrobial activity compared to HL. The DNA cleavage activity of HL and complexes 1–4 was monitored by the agarose gel electrophoresis method. The antioxidant property of the prepared compounds was assessed by using 2,2′-diphenyl-1-picrylhydrazyl (DPPH) free radical scavenging method. DNA binding properties of HL and complexes 1–4 have been investigated by electronic absorption technique and viscometric measurements.

scholarly journals Synthesis and in vitro Cytotoxicity Study of Novel 4-Substituted Quinazolines Encompassed with Thiazolidinone and Azetidinone

2020 ◽  
Vol 32 (10) ◽  
pp. 2617-2623
Author(s):  
Akash Jori ◽  
Sheshagiri R. Dixit ◽  
Gurubasavraj V. Pujar
Keyword(s):  
Antioxidant Activity ◽  
Free Radical ◽  
Dna Binding ◽  
Anticancer Activity ◽  
Radical Scavenging Activity ◽  
Radical Scavenging ◽  
In Vitro Cytotoxicity ◽  
Free Radical Scavenging ◽  
Binding Studies

A series of quinazolines encompassed with thiazolidinone and azetidinone have been synthesized and evaluated for their antioxidant, anticancer and DNA binding studies. All the synthesized compounds were characterized by IR, 1H & 13C NMR and mass spectra. Antioxidant activity was carried out using % free radical scavenging by DPPH assay. Compounds 4b, 5b and 5d have shown better antioxidant activity (60, 67 and 66%, respectively) among the tested compounds. Compounds having % free radical scavenging activity more than 55% were evaluated for anticancer activity by MTT assay towards cell lines A-549 (lung carcinoma) and MDA-231 (human breast cancer). Results revealed that the tested compounds exhibited moderate to low anticancer activity. Further, DNA binding activity was studied by absorption titration method for all the synthesized compounds, and compound 5b showed a good binding constant of 70.05 and % hyperchromicity of 82.93%.

Structural, spectroscopic, radical scavenging activity, molecular docking and DFT studies of a synthesized Schiff base compound

2019 ◽  
Vol 1179 ◽  
pp. 205-215 ◽  
Author(s):  
Halil Gökce ◽  
Yelda Bingöl Alpaslan ◽  
Celal Tuğrul Zeyrek ◽  
Erbil Ağar ◽  
Aytaç Güder ◽  
...  
Keyword(s):  
Schiff Base ◽  
Molecular Docking ◽  
Radical Scavenging Activity ◽  
Radical Scavenging ◽  
Scavenging Activity ◽  
Dft Studies ◽  
Schiff Base Compound ◽  
Base Compound

Natural Dibenzoxazepinones from Leaves of Carex distachya: Structural Elucidation and Radical Scavenging Activity.

ChemInform ◽  
2007 ◽  
Vol 38 (24) ◽  
Author(s):  
Antonio Fiorentino ◽  
Brigida D'Abrosca ◽  
Severina Pacifico ◽  
Giuseppe Cefarelli ◽  
Piera Uzzo ◽  
...  
Keyword(s):  
Radical Scavenging Activity ◽  
Radical Scavenging ◽  
Structural Elucidation ◽  
Scavenging Activity
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