Design, synthesis and activity of novel 2,6-disubstituted purine derivatives, potential small molecule inhibitors of signal transducer and activator of transcription 3

European Journal of Medicinal Chemistry ◽

10.1016/j.ejmech.2019.06.017 ◽

2019 ◽

Vol 179 ◽

pp. 218-232 ◽

Author(s):

Xuebao Wang ◽

Qin He ◽

Kaiqi Wu ◽

Taoning Guo ◽

Xuze Du ◽

...

Keyword(s):

Small Molecule ◽

Small Molecule Inhibitors ◽

Signal Transducer ◽

Purine Derivatives ◽

Design Synthesis ◽

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Design, Synthesis and Biological Evaluation of Small-Molecule Inhibitors of Signal Transducer and Activator of Transcription 3 (STAT3) Signaling Pathway

Chinese Journal of Organic Chemistry ◽

10.6023/cjoc201602030 ◽

2016 ◽

Vol 36 (8) ◽

pp. 1854

Author(s):

Dingding Gao ◽

Keting Bao ◽

Mingming Zhang ◽

Yingxia Li

Keyword(s):

Signaling Pathway ◽

Small Molecule ◽

Small Molecule Inhibitors ◽

Biological Evaluation ◽

Signal Transducer ◽

Design Synthesis ◽

Stat3 Signaling ◽

Stat3 Signaling Pathway ◽

Transcription 3 ◽

Synthesis And Biological Evaluation

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Structure-Based Discovery of Potent and Selective Small-Molecule Inhibitors Targeting Signal Transducer and Activator of Transcription 3 (STAT3)

European Journal of Medicinal Chemistry ◽

10.1016/j.ejmech.2021.113525 ◽

2021 ◽

pp. 113525

Author(s):

Qiuyao Huang ◽

Yan Zhong ◽

Bingbing Li ◽

Shumin Ouyang ◽

Lin Deng ◽

...

Keyword(s):

Small Molecule ◽

Small Molecule Inhibitors ◽

Signal Transducer ◽

Targeting Signal ◽

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Preclinical Characterization of Signal Transducer and Activator of Transcription 3 Small Molecule Inhibitors for Primary and Metastatic Brain Cancer Therapy

Journal of Pharmacology and Experimental Therapeutics ◽

10.1124/jpet.114.214619 ◽

2014 ◽

Vol 349 (3) ◽

pp. 458-469 ◽

Author(s):

Hikmat H. Assi ◽

Chris Paran ◽

Nathan VanderVeen ◽

Jonathan Savakus ◽

Robert Doherty ◽

...

Keyword(s):

Cancer Therapy ◽

Small Molecule ◽

Brain Cancer ◽

Small Molecule Inhibitors ◽

Signal Transducer ◽

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Small Molecule Inhibitors of Signal Transducer and Activator of Transcription 3 (Stat3) Protein

Journal of Medicinal Chemistry ◽

10.1021/jm300207s ◽

2012 ◽

Vol 55 (15) ◽

pp. 6645-6668 ◽

Author(s):

Bikash Debnath ◽

Shili Xu ◽

Nouri Neamati

Keyword(s):

Small Molecule ◽

Small Molecule Inhibitors ◽

Signal Transducer ◽

Transcription 3

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Identification and characterization of small molecule inhibitors of signal transducer and activator of transcription 3 (STAT3) signaling pathway by virtual screening

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/j.bmcl.2013.01.056 ◽

2013 ◽

Vol 23 (7) ◽

pp. 2225-2229 ◽

Author(s):

Mingming Zhang ◽

Weiliang Zhu ◽

Ning Ding ◽

Wei Zhang ◽

Yingxia Li

Keyword(s):

Virtual Screening ◽

Signaling Pathway ◽

Small Molecule ◽

Small Molecule Inhibitors ◽

Signal Transducer ◽

Stat3 Signaling ◽

Stat3 Signaling Pathway ◽

Transcription 3 ◽

Identification And Characterization

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Protection against Angiotensin II-induced endothelial dysfunction and hypertension via small molecule inhibitors of signal transducer and activator of transcription 3

10.17077/etd.ydzu98x2 ◽

2012 ◽

Author(s):

Andrew William Johnson

Keyword(s):

Angiotensin Ii ◽

Endothelial Dysfunction ◽

Small Molecule ◽

Small Molecule Inhibitors ◽

Signal Transducer ◽

Transcription 3

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Small-Molecule Inhibitors of Signal Transducer and Activator of Transcription 3 Protect Against Angiotensin II–Induced Vascular Dysfunction and Hypertension

Hypertension ◽

10.1161/hypertensionaha.111.00299 ◽

2013 ◽

Vol 61 (2) ◽

pp. 437-442 ◽

Author(s):

Andrew W. Johnson ◽

Dale A. Kinzenbaw ◽

Mary L. Modrick ◽

Frank M. Faraci

Keyword(s):

Angiotensin Ii ◽

Small Molecule ◽

Small Molecule Inhibitors ◽

Vascular Dysfunction ◽

Signal Transducer ◽

Transcription 3

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SCH66336, inhibitor of protein farnesylation, blocks signal transducer and activators of transcription 3 signaling in lung cancer and interacts with a small molecule inhibitor of epidermal growth factor receptor/human epidermal growth factor receptor 2

Anti-Cancer Drugs ◽

10.1097/cad.0b013e3282f1a908 ◽

2008 ◽

Vol 19 (1) ◽

pp. 9-16 ◽

Author(s):

Afshin Dowlati ◽

Amy Kluge ◽

David Nethery ◽

Balazs Halmos ◽

Jeffrey A. Kern

Keyword(s):

Lung Cancer ◽

Epidermal Growth Factor Receptor ◽

Growth Factor ◽

Epidermal Growth Factor ◽

Small Molecule ◽

Growth Factor Receptor ◽

Signal Transducer ◽

Molecule Inhibitor ◽

Epidermal Growth ◽

Transcription 3

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Discovery of potent anticancer agent HJC0416, an orally bioavailable small molecule inhibitor of signal transducer and activator of transcription 3 (STAT3)

European Journal of Medicinal Chemistry ◽

10.1016/j.ejmech.2014.05.049 ◽

2014 ◽

Vol 82 ◽

pp. 195-203 ◽

Author(s):

Haijun Chen ◽

Zhengduo Yang ◽

Chunyong Ding ◽

Ailian Xiong ◽

Christopher Wild ◽

...

Keyword(s):

Small Molecule ◽

Anticancer Agent ◽

Small Molecule Inhibitor ◽

Signal Transducer ◽

Molecule Inhibitor ◽

Orally Bioavailable ◽

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A novel small-molecule inhibitor of hepatitis C virus replication acts by suppressing signal transducer and activator of transcription 3

Journal of Antimicrobial Chemotherapy ◽

10.1093/jac/dkv077 ◽

2015 ◽

Author(s):

Y. Niu ◽

Y. Si ◽

Y. Li ◽

X. Chi ◽

X. Li ◽

...

Keyword(s):

Hepatitis C Virus ◽

Hepatitis C ◽

Virus Replication ◽

Small Molecule ◽

Small Molecule Inhibitor ◽

Signal Transducer ◽

Molecule Inhibitor ◽

Transcription 3

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