SCH66336, inhibitor of protein farnesylation, blocks signal transducer and activators of transcription 3 signaling in lung cancer and interacts with a small molecule inhibitor of epidermal growth factor receptor/human epidermal growth factor receptor 2

Afshin Dowlati; Amy Kluge; David Nethery; Balazs Halmos; Jeffrey A. Kern

doi:10.1097/cad.0b013e3282f1a908

SCH66336, inhibitor of protein farnesylation, blocks signal transducer and activators of transcription 3 signaling in lung cancer and interacts with a small molecule inhibitor of epidermal growth factor receptor/human epidermal growth factor receptor 2

Anti-Cancer Drugs ◽

10.1097/cad.0b013e3282f1a908 ◽

2008 ◽

Vol 19 (1) ◽

pp. 9-16 ◽

Cited By ~ 12

Author(s):

Afshin Dowlati ◽

Amy Kluge ◽

David Nethery ◽

Balazs Halmos ◽

Jeffrey A. Kern

Keyword(s):

Lung Cancer ◽

Epidermal Growth Factor Receptor ◽

Growth Factor ◽

Epidermal Growth Factor ◽

Small Molecule ◽

Growth Factor Receptor ◽

Signal Transducer ◽

Molecule Inhibitor ◽

Epidermal Growth ◽

Transcription 3

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Signal Transducer and Activator of Transcription 3 Is Required for the Oncogenic Effects of Non–Small-Cell Lung Cancer–Associated Mutations of the Epidermal Growth Factor Receptor

Cancer Research ◽

10.1158/0008-5472.can-05-3757 ◽

2006 ◽

Vol 66 (6) ◽

pp. 3162-3168 ◽

Cited By ~ 160

Author(s):

James V. Alvarez ◽

Heidi Greulich ◽

William R. Sellers ◽

Matthew Meyerson ◽

David A. Frank

Keyword(s):

Lung Cancer ◽

Epidermal Growth Factor Receptor ◽

Growth Factor ◽

Epidermal Growth Factor ◽

Growth Factor Receptor ◽

Small Cell ◽

Signal Transducer ◽

Small Cell Lung ◽

Epidermal Growth ◽

Transcription 3

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Intercellular contact augments epidermal growth factor receptor (EGFR) and signal transducer and activator of transcription 3 (STAT3)-activation which increases podoplanin-expression in order to promote squamous cell carcinoma motility

Cellular Signalling ◽

10.1016/j.cellsig.2012.12.004 ◽

2013 ◽

Vol 25 (4) ◽

pp. 760-765 ◽

Cited By ~ 8

Author(s):

Mizue Fujii ◽

Masaru Honma ◽

Hidetoshi Takahashi ◽

Akemi Ishida-Yamamoto ◽

Hajime Iizuka

Keyword(s):

Squamous Cell Carcinoma ◽

Epidermal Growth Factor Receptor ◽

Growth Factor ◽

Epidermal Growth Factor ◽

Growth Factor Receptor ◽

Intercellular Contact ◽

Signal Transducer ◽

Podoplanin Expression ◽

Epidermal Growth ◽

Transcription 3

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A review of small-molecule epidermal growth factor receptor-specific tyrosine kinase inhibitors in development for non-small cell lung cancer

Seminars in Oncology ◽

10.1053/j.seminoncol.2003.12.019 ◽

2004 ◽

Vol 31 ◽

pp. 83-92 ◽

Cited By ~ 8

Author(s):

Katrina Y Glover ◽

Roman Perez-Soler ◽

Vassiliki A Papadimitradopoulou

Keyword(s):

Lung Cancer ◽

Epidermal Growth Factor Receptor ◽

Growth Factor ◽

Epidermal Growth Factor ◽

Small Molecule ◽

Kinase Inhibitors ◽

Growth Factor Receptor ◽

Small Cell ◽

Small Cell Lung ◽

Epidermal Growth

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The absolute oral bioavailability (BA) of 150-mg and bioequivalence (BE) of six 25- and one 150-mg erlotinib (E) tablets, a small molecule inhibitor of the epidermal growth factor receptor (EGFR), in healthy volunteers

Journal of Clinical Oncology ◽

10.1200/jco.2005.23.16_suppl.3163 ◽

2005 ◽

Vol 23 (16_suppl) ◽

pp. 3163-3163

Author(s):

B. L. Lum ◽

J. Lu ◽

S. M. Eppler ◽

M. Hamilton ◽

J. Wolf ◽

...

Keyword(s):

Epidermal Growth Factor Receptor ◽

Growth Factor ◽

Epidermal Growth Factor ◽

Healthy Volunteers ◽

Small Molecule ◽

Oral Bioavailability ◽

Growth Factor Receptor ◽

Molecule Inhibitor ◽

Absolute Oral Bioavailability ◽

Epidermal Growth

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Small Molecule Inhibitors of the Epidermal Growth Factor Receptor in Patients with Non–Small-Cell Lung Cancer An Update of Clinical Data from the 2001 American Society of Clinical Oncology Meeting

Clinical Lung Cancer ◽

10.1016/s1525-7304(11)70729-x ◽

2001 ◽

Vol 2 (4) ◽

pp. 258-260

Author(s):

Amy I. D'Orazio ◽

B. Diane Gambill ◽

Mark Kris ◽

Chandra P. Belani

Keyword(s):

Lung Cancer ◽

Epidermal Growth Factor Receptor ◽

Growth Factor ◽

Epidermal Growth Factor ◽

Small Molecule ◽

Growth Factor Receptor ◽

Small Cell ◽

Small Cell Lung ◽

Epidermal Growth ◽

American Society

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METABOLISM AND EXCRETION OF ERLOTINIB, A SMALL MOLECULE INHIBITOR OF EPIDERMAL GROWTH FACTOR RECEPTOR TYROSINE KINASE, IN HEALTHY MALE VOLUNTEERS

Drug Metabolism and Disposition ◽

10.1124/dmd.105.007765 ◽

2005 ◽

Vol 34 (3) ◽

pp. 420-426 ◽

Cited By ~ 152

Author(s):

Jie Ling ◽

Kim A. Johnson ◽

Zhuang Miao ◽

Ashok Rakhit ◽

Michael P. Pantze ◽

...

Keyword(s):

Epidermal Growth Factor Receptor ◽

Growth Factor ◽

Epidermal Growth Factor ◽

Tyrosine Kinase ◽

Small Molecule ◽

Receptor Tyrosine Kinase ◽

Growth Factor Receptor ◽

Healthy Male ◽

Molecule Inhibitor ◽

Epidermal Growth

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Alpha-1 adrenergic receptor transactivates signal transducer and activator of transcription-3 (Stat3) through activation of Src and epidermal growth factor receptor (EGFR) in hepatocytes

Journal of Cellular Physiology ◽

10.1002/jcp.21420 ◽

2008 ◽

Vol 216 (2) ◽

pp. 486-497 ◽

Cited By ~ 24

Author(s):

Chang Han ◽

William C. Bowen ◽

George K. Michalopoulos ◽

Tong Wu

Keyword(s):

Epidermal Growth Factor Receptor ◽

Growth Factor ◽

Epidermal Growth Factor ◽

Adrenergic Receptor ◽

Growth Factor Receptor ◽

Signal Transducer ◽

Epidermal Growth ◽

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Epidermal Growth Factor Receptor Cooperates with Signal Transducer and Activator of Transcription 3 to Induce Epithelial-Mesenchymal Transition in Cancer Cells via Up-regulation of TWIST Gene Expression

Cancer Research ◽

10.1158/0008-5472.can-07-0575 ◽

2007 ◽

Vol 67 (19) ◽

pp. 9066-9076 ◽

Cited By ~ 430

Author(s):

Hui-Wen Lo ◽

Sheng-Chieh Hsu ◽

Weiya Xia ◽

Xinyu Cao ◽

Jin-Yuan Shih ◽

...

Keyword(s):

Gene Expression ◽

Epidermal Growth Factor Receptor ◽

Growth Factor ◽

Epidermal Growth Factor ◽

Epithelial Mesenchymal Transition ◽

Growth Factor Receptor ◽

Signal Transducer ◽

Mesenchymal Transition ◽

Epidermal Growth ◽

Transcription 3

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Combined Targeting of Epidermal Growth Factor Receptor, Signal Transducer and Activator of Transcription-3, and Bcl-XL Enhances Antitumor Effects in Squamous Cell Carcinoma of the Head and Neck

Molecular Pharmacology ◽

10.1124/mol.107.044636 ◽

2008 ◽

Vol 73 (6) ◽

pp. 1632-1642 ◽

Cited By ~ 53

Author(s):

Amanda L. Boehm ◽

Malabika Sen ◽

Raja Seethala ◽

William E. Gooding ◽

Maria Freilino ◽

...

Keyword(s):

Squamous Cell Carcinoma ◽

Epidermal Growth Factor Receptor ◽

Growth Factor ◽

Epidermal Growth Factor ◽

Growth Factor Receptor ◽

Signal Transducer ◽

Antitumor Effects ◽

Receptor Signal ◽

Epidermal Growth ◽

Transcription 3

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Lapatinib: A small-molecule inhibitor of epidermal growth factor receptor and human epidermal growth factor receptor—2 tyrosine kinases used in the treatment of breast cancer

Clinical Therapeutics ◽

10.1016/j.clinthera.2009.11.029 ◽

2009 ◽

Vol 31 ◽

pp. 2332-2348 ◽

Cited By ~ 56

Author(s):

Amye J. Tevaarwerk ◽

Jill M. Kolesar

Keyword(s):

Breast Cancer ◽

Epidermal Growth Factor Receptor ◽

Growth Factor ◽

Epidermal Growth Factor ◽

Small Molecule ◽

Tyrosine Kinases ◽

Growth Factor Receptor ◽

Human Epidermal Growth Factor ◽

Molecule Inhibitor ◽

Epidermal Growth

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