Design, synthesis and structure-activity relationship studies of 4-indole-2-arylaminopyrimidine derivatives as anti-inflammatory agents for acute lung injury

European Journal of Medicinal Chemistry ◽

10.1016/j.ejmech.2021.113766 ◽

2021 ◽

pp. 113766

Author(s):

Tianpeng Chen ◽

Yingying Wei ◽

Gaoyang Zhu ◽

Huajun Zhao ◽

Xingxian Zhang

Keyword(s):

Acute Lung Injury ◽

Lung Injury ◽

Structure Activity Relationship ◽

Activity Relationship ◽

Design Synthesis ◽

Structure Activity ◽

Anti Inflammatory

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Cover Picture: Design, Synthesis, and Structure-Activity Relationship Analysis of Thiazolo[3,2-a ]pyrimidine Derivatives with Anti-inflammatory Activity in Acute Lung Injury (ChemMedChem 13/2017)

ChemMedChem ◽

10.1002/cmdc.201700367 ◽

2017 ◽

Vol 12 (13) ◽

pp. 1013-1013

Author(s):

Lingfeng Chen ◽

Yiyi Jin ◽

Weitao Fu ◽

Siyang Xiao ◽

Chen Feng ◽

...

Keyword(s):

Acute Lung Injury ◽

Lung Injury ◽

Structure Activity Relationship ◽

Inflammatory Activity ◽

Activity Relationship ◽

Pyrimidine Derivatives ◽

Design Synthesis ◽

Relationship Analysis ◽

Structure Activity ◽

Anti Inflammatory

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Design, Synthesis, and Structure-Activity Relationship Analysis of Thiazolo[3,2-a ]pyrimidine Derivatives with Anti-inflammatory Activity in Acute Lung Injury

ChemMedChem ◽

10.1002/cmdc.201700175 ◽

2017 ◽

Vol 12 (13) ◽

pp. 1022-1032 ◽

Author(s):

Lingfeng Chen ◽

Yiyi Jin ◽

Weitao Fu ◽

Siyang Xiao ◽

Chen Feng ◽

...

Keyword(s):

Acute Lung Injury ◽

Lung Injury ◽

Structure Activity Relationship ◽

Inflammatory Activity ◽

Activity Relationship ◽

Pyrimidine Derivatives ◽

Design Synthesis ◽

Relationship Analysis ◽

Structure Activity ◽

Anti Inflammatory

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Discovery of a novel COX-2 inhibitor as an orally potent anti-pyretic and anti-inflammatory drug: Design, synthesis, and structure–activity relationship

Biochemical Pharmacology ◽

10.1016/j.bcp.2011.06.036 ◽

2011 ◽

Vol 82 (7) ◽

pp. 755-768 ◽

Author(s):

Shigeo Hayashi ◽

Yoko Sumi ◽

Naomi Ueno ◽

Akio Murase ◽

Junji Takada

Keyword(s):

Drug Design ◽

Structure Activity Relationship ◽

Activity Relationship ◽

Design Synthesis ◽

Inflammatory Drug ◽

Structure Activity ◽

Cox 2 ◽

Anti Inflammatory

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Novel acid-type cyclooxygenase-2 inhibitors: Design, synthesis, and structure–activity relationship for anti-inflammatory drug

European Journal of Medicinal Chemistry ◽

10.1016/j.ejmech.2012.01.053 ◽

2012 ◽

Vol 50 ◽

pp. 179-195 ◽

Author(s):

Shigeo Hayashi ◽

Naomi Ueno ◽

Akio Murase ◽

Yoko Nakagawa ◽

Junji Takada

Keyword(s):

Structure Activity Relationship ◽

Cyclooxygenase 2 ◽

Activity Relationship ◽

Design Synthesis ◽

Inflammatory Drug ◽

Structure Activity ◽

Acid Type ◽

Anti Inflammatory ◽

Cyclooxygenase 2 Inhibitors

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Anti-inflammatory phospholipase-A2 inhibitors. II. Design, synthesis and structure-activity relationship

European Journal of Medicinal Chemistry ◽

10.1016/0223-5234(92)90138-q ◽

1992 ◽

Vol 27 (6) ◽

pp. 595-610 ◽

Author(s):

W Wilkerson ◽

I DeLucca ◽

W Galbraith ◽

J Kerr

Keyword(s):

Phospholipase A2 ◽

Structure Activity Relationship ◽

Activity Relationship ◽

Design Synthesis ◽

Structure Activity ◽

Anti Inflammatory ◽

Phospholipase A2 Inhibitors

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Design, synthesis and structure–activity relationship studies of novel and diverse cyclooxygenase-2 inhibitors as anti-inflammatory drugs

Journal of Enzyme Inhibition and Medicinal Chemistry ◽

10.3109/14756366.2013.864650 ◽

2014 ◽

Vol 29 (6) ◽

pp. 846-867 ◽

Author(s):

Shigeo Hayashi ◽

Naomi Ueno ◽

Akio Murase ◽

Junji Takada

Keyword(s):

Structure Activity Relationship ◽

Cyclooxygenase 2 ◽

Activity Relationship ◽

Design Synthesis ◽

Structure Activity ◽

Inflammatory Drugs ◽

Anti Inflammatory ◽

Cyclooxygenase 2 Inhibitors

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Design, Synthesis, and Structure–Activity Relationship Study of Novel Indole-2-carboxamide Derivatives as Anti-inflammatory Agents for the Treatment of Sepsis

Journal of Medicinal Chemistry ◽

10.1021/acs.jmedchem.5b02006 ◽

2016 ◽

Vol 59 (10) ◽

pp. 4637-4650 ◽

Author(s):

Zhiguo Liu ◽

Longguang Tang ◽

Heping Zhu ◽

Tingting Xu ◽

Chenyu Qiu ◽

...

Keyword(s):

Structure Activity Relationship ◽

Activity Relationship ◽

Design Synthesis ◽

Structure Activity ◽

Relationship Study ◽

Anti Inflammatory

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Design, Synthesis and Structure-Activity Relationship Studies of Novel 4 (1-adamantyl) Phenyl Analogues as HIF-1α Inhibitors

Medicinal Chemistry ◽

10.2174/1573406412666151109113007 ◽

2016 ◽

Vol 12 (4) ◽

pp. 338-346 ◽

Author(s):

Yan Xia ◽

Qiong Duan ◽

Bao-Hua Zhao ◽

Dong-Feng Li ◽

Rui-Bin Hou

Keyword(s):

Structure Activity Relationship ◽

Activity Relationship ◽

Design Synthesis ◽

Structure Activity

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Design, synthesis, biological evaluation and structure-activity relationship study of quinazolin-4(3H)-one derivatives as novel USP7 inhibitors

European Journal of Medicinal Chemistry ◽

10.1016/j.ejmech.2021.113291 ◽

2021 ◽

pp. 113291

Author(s):

Peng Li ◽

Ying Liu ◽

Hua Yang ◽

Hong-Min Liu

Keyword(s):

Structure Activity Relationship ◽

Biological Evaluation ◽

Activity Relationship ◽

Design Synthesis ◽

Structure Activity ◽

Relationship Study

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New substituted pyrazolones and dipyrazolotriazines as promising tyrosyl-tRNA synthetase and peroxiredoxin-5 inhibitors: Design, synthesis, molecular docking and structure-activity relationship (SAR) analysis

Bioorganic Chemistry ◽

10.1016/j.bioorg.2021.104704 ◽

2021 ◽

Vol 109 ◽

pp. 104704

Author(s):

Ismail M.M. Othman ◽

Mohamed A.M. Gad-Elkareem ◽

El Hassane Anouar ◽

Kaïss Aouadi ◽

Mejdi Snoussi ◽

...

Keyword(s):

Molecular Docking ◽

Structure Activity Relationship ◽

Trna Synthetase ◽

Activity Relationship ◽

Design Synthesis ◽

Structure Activity ◽

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