O26. A review on target volume delineation using FDG-PET/CT images for radiation oncology

2016 ◽  
Vol 32 ◽  
pp. 149
Author(s):  
M. du Toit ◽  
A. Potgieter ◽  
M. Heunis ◽  
R. Boellaard ◽  
J. Pruim
2008 ◽  
Vol 70 (5) ◽  
pp. 1423-1426 ◽  
Author(s):  
Maria Chiara Bassi ◽  
Lucia Turri ◽  
Gianmauro Sacchetti ◽  
Gianfranco Loi ◽  
Barbara Cannillo ◽  
...  

2009 ◽  
Vol 27 (15_suppl) ◽  
pp. 7574-7574 ◽  
Author(s):  
Y. Xu ◽  
S. Ma ◽  
D. Yu ◽  
J. Wang ◽  
L. Zhang ◽  
...  

7574 Background: 18F-fluorodeoxyglucose (FDG)-positron emission tomography (PET) /computed tomography (CT) has a potential improvement for staging and radiation treatment (RT) planning of various tumor sites. But from a clinical standpoint, the open questions are essentially the following: to what extent does PET/CT change the target volume? Can PET/CT reduce inter-observer variability in target volume delineation? We analyzed the use of FDG-PET/ CT images for staging and evaluated the impact of FDG- PET/CT on the radiotherapy volume delineation compared with CT in patients with non-small cell lung cancer (NSCLC) candidates for radiotherapy. Intraobserver variation in delineating tumor volumes was also observed. Methods: Twenty-three patients with stage I-III NSCLC were enrolled in this pilot study and were treated with fractionated RT based therapy with or without chemotherapy. FDG-PET/CT scans were acquired within 2 weeks prior to RT. PET and CT data sets were sent to the treatment planning system Pinnacle through compact disc. The CT and PET images were subsequently fused by means of a dedicated radiation treatment planning system. Gross Tumor Volume (GTV) was contoured by four radiation oncologists respectively on CT (CT-GTV) and PET/CT images (PET/CT-GTV). The resulting volumes were analyzed and compared. Results: For the first phase, two radiation oncologists outlined together the contours achieving a final consensus. Based on PET/CT, changes in TNM categories occurred in 8/23 cases (35%). Radiation targeting with fused FDG-PET and CT images resulted in alterations in radiation therapy planning in 12/20 patients (60%) by comparison with CT targeting. The most prominent changes in GTV have been observed in cases with atelectasis. For the second phase was four intraobserver variation in delineating tumor volumes. The mean ratio of largest to smallest CT-based GTV was 2.31 (range 1.01–5.96). The addition of the PET data reduced the mean ratio to 1.46 (range 1.12–2.27). Conclusions: PET/CT fusion images could have a potential impact on both tumor staging and treatment planning. Implementing matched PET/CT reduced observer variation in delineating tumor volumes significantly with respect to CT only. [Table: see text]


2012 ◽  
Vol 188 (7) ◽  
pp. 592-598 ◽  
Author(s):  
R.A. Bundschuh ◽  
N. Andratschke ◽  
J. Dinges ◽  
M.N. Duma ◽  
S.T. Astner ◽  
...  

2011 ◽  
Vol 99 ◽  
pp. S355
Author(s):  
L. Vigna ◽  
L. Deantonio ◽  
R. Matheoud ◽  
G. Sacchetti ◽  
G. Loi ◽  
...  

2012 ◽  
Vol 7 (1) ◽  
Author(s):  
Hansjörg Vees ◽  
Nathalie Casanova ◽  
Thomas Zilli ◽  
Hestia Imperiano ◽  
Osman Ratib ◽  
...  

2011 ◽  
Vol 99 ◽  
pp. S432-S433
Author(s):  
R. Lazzari ◽  
A. Cecconi ◽  
V. Dell'Acqua ◽  
A. Vavassori ◽  
L.L. Travaini ◽  
...  

Author(s):  
Elizabeth E. Olanloye ◽  
Aarthi Ramlaul ◽  
Atara I. Ntekim ◽  
Segun S. Adeyemi

Abstract Aim: The aim of this systematic review was to synthesise and summarise evidence surrounding the clinical use of fluoro-2-deoxy-d-glucose positron emission tomography/computed tomography (FDG-PET/CT) and magnetic resonance imaging (MRI) for target volume delineation (TVD) in rectal cancer radiotherapy planning. Methods: PubMed, EMBASE, Cochrane library, CINAHL, Web of Science and Scopus databases and other sources were systematically queried using keywords and relevant synonyms. Eligible full-text studies were assessed for methodological quality using the QUADAS-2 tool. Results: Eight of the 1448 studies identified met the inclusion criteria. Findings showed that MRI significantly delineate larger tumour volumes (TVs) than FDG-PET/CT while diffusion-weighted magnetic resonance imaging (DW-MRI) defined smaller gross tumour volumes (GTVs) compared to T2 weighted-Magnetic Resonance Image. CT-based GTVs were found to be larger compared to FDG-PET/CT. FDG-PET/CT also identified new lesions in 15–17% patients and TVs extending outside the routinely used clinical standard CT TV in 29–83% patients. Between observers, delineated volumes were similar and consistent between MRI sequences, whereas interobserver agreement was significantly improved with FDG-PET/CT than CT. Conclusion: FDG-PET/CT and DW-MRI appear to delineate smaller rectal TVs and show improved interobserver variability. Overall, this study provides valuable insights into the amount of attention in the research literature that has been paid to imaging for TVD in rectal cancer.


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