scholarly journals Evaluation of alternative parameter settings for dose restoration and full plan adaptation in IMPT for prostate cancer

2021 ◽  
Vol 92 ◽  
pp. 15-23
Author(s):  
Thyrza Z. Jagt ◽  
Sebastiaan Breedveld ◽  
Mischa S. Hoogeman
Keyword(s):  
Prostate Cancer ◽  
Plan Adaptation

scholarly journals Dosimetric benefits of daily treatment plan adaptation for prostate cancer stereotactic body radiotherapy

2021 ◽  
Vol 16 (1) ◽  
Author(s):  
Miriam Eckl ◽  
Gustavo R. Sarria ◽  
Sandra Springer ◽  
Marvin Willam ◽  
Arne M. Ruder ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Treatment Plan ◽  
Cone Beam Ct ◽  
Dose Calculation ◽  
Adaptation Strategy ◽  
Daily Basis ◽  
Daily Treatment ◽  
Generative Adversarial Network ◽  
Image Guided Radiotherapy ◽  
Plan Adaptation

Abstract Background Hypofractionation is increasingly being applied in radiotherapy for prostate cancer, requiring higher accuracy of daily treatment deliveries than in conventional image-guided radiotherapy (IGRT). Different adaptive radiotherapy (ART) strategies were evaluated with regard to dosimetric benefits. Methods Treatments plans for 32 patients were retrospectively generated and analyzed according to the PACE-C trial treatment scheme (40 Gy in 5 fractions). Using a previously trained cycle-generative adversarial network algorithm, synthetic CT (sCT) were generated out of five daily cone-beam CT. Dose calculation on sCT was performed for four different adaptation approaches: IGRT without adaptation, adaptation via segment aperture morphing (SAM) and segment weight optimization (ART1) or additional shape optimization (ART2) as well as a full re-optimization (ART3). Dose distributions were evaluated regarding dose-volume parameters and a penalty score. Results Compared to the IGRT approach, the ART1, ART2 and ART3 approaches substantially reduced the V37Gy(bladder) and V36Gy(rectum) from a mean of 7.4cm3 and 2.0cm3 to (5.9cm3, 6.1cm3, 5.2cm3) as well as to (1.4cm3, 1.4cm3, 1.0cm3), respectively. Plan adaptation required on average 2.6 min for the ART1 approach and yielded doses to the rectum being insignificantly different from the ART2 approach. Based on an accumulation over the total patient collective, a penalty score revealed dosimetric violations reduced by 79.2%, 75.7% and 93.2% through adaptation. Conclusion Treatment plan adaptation was demonstrated to adequately restore relevant dose criteria on a daily basis. While for SAM adaptation approaches dosimetric benefits were realized through ensuring sufficient target coverage, a full re-optimization mainly improved OAR sparing which helps to guide the decision of when to apply which adaptation strategy.

PO-1194: MR-based adaptive IGRT of prostate cancer: feasibility, plan adaptation and acute toxicity

2020 ◽  
Vol 152 ◽  
pp. S629
Author(s):  
D. Wegener ◽  
F. Paulsen ◽  
C. De Colle ◽  
D. Thorwart ◽  
U. Grosse ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Acute Toxicity ◽  
Plan Adaptation

Sigmoidoscopic findings following radiation for prostate cancer

2001 ◽  
Vol 120 (5) ◽  
pp. A284-A284
Author(s):  
T BOLIN ◽  
A KNEEBONE ◽  
T LARSSON
Keyword(s):  
Prostate Cancer

1625: Neuroligin 4 ISOFORM Y: A Novel Marker for Prostate Cancer

2007 ◽  
Vol 177 (4S) ◽  
pp. 538-539
Author(s):  
Joseph F. Pazona ◽  
C. Shad Thaxton ◽  
Neema Navai ◽  
Brian T. Helfand ◽  
Lee C. Zhao ◽  
...  
Keyword(s):  
Prostate Cancer

232: Natural History of Treated Biochemical Recurrence after Radical Prostatectomy for Prostate Cancer

2007 ◽  
Vol 177 (4S) ◽  
pp. 77-78
Author(s):  
Christopher R. Porter ◽  
Jochen Walz ◽  
Andrea Gallina ◽  
Claudio Jeldres ◽  
Koichi Kodama ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Radical Prostatectomy ◽  
Natural History ◽  
Biochemical Recurrence ◽  
History Of

466: Age is an Independent Predictor of Bone Metastasis at Prostate Cancer Diagnosis

2007 ◽  
Vol 177 (4S) ◽  
pp. 156-156
Author(s):  
Andrea Salonia ◽  
Pierre I. Karakiewicz ◽  
Andrea Gallina ◽  
Alberto Briganti ◽  
Tommaso C. Camerata ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Bone Metastasis ◽  
Cancer Diagnosis ◽  
Independent Predictor ◽  
Prostate Cancer Diagnosis

456: Genetic Polymorphisms in CYP17, CYPJA4, CYP19 and SRD5A2 and Prostate Cancer Risk in African American Men: the Flint Men's Health Study

2007 ◽  
Vol 177 (4S) ◽  
pp. 153-153
Author(s):  
Aruna V. Sarma ◽  
Leslie Lange ◽  
Anna Ray ◽  
Ethan Lange ◽  
Rodney L. Dunn ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
African American ◽  
Cancer Risk ◽  
Genetic Polymorphisms ◽  
African American Men ◽  
Prostate Cancer Risk ◽  
Men’S Health ◽  
Health Study ◽  
Men's Health

664: CXCL12/CXCR4 Trans-Activation of HER2 in Lipid Rafts of Prostate Cancer Cell Membranes Promotes Bone Metastasis

2007 ◽  
Vol 177 (4S) ◽  
pp. 223-223
Author(s):  
Sreenivasa R. Chinni ◽  
Hamilto Yamamoto ◽  
Zhong Dong ◽  
Aaron Sabbota ◽  
Sanaa Nabha ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Bone Metastasis ◽  
Lipid Rafts ◽  
Cancer Cell ◽  
Cell Membranes ◽  
Prostate Cancer Cell
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