Precise segmentation of abdomen diseases like tumor, cyst and stone are crucial in the design of a computer aided diagnostic system. The complexity of shapes and similarity of texture of disease with the surrounding tissues makes the segmentation of abdomen related diseases much more challenging. Thus, this paper is devoted to the segmentation of abdomen diseases using active contour models. The active contour models are formulated using the level-set method. Edge-based Distance Regularized Level Set Evolution (DRLSE) and region based Selective Binary and Gaussian Filtering Regularized Level Set (SBGFRLS) are used for segmentation of various abdomen diseases. These segmentation methods are applied on 60 CT images (20 images each of tumor, cyst and stone). Comparative analysis shows that edge-based active contour models are able to segment abdomen disease more accurately than region-based level set active contour model.