cellular networks
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2022 ◽  
Author(s):  
Jonas Søndergaard ◽  
Janyerkye Tulyeu ◽  
Ryuya Edahiro ◽  
Yuya Shira ◽  
Yuta Yamaguchi ◽  
...  

Using single-cell proteomics by mass cytometry, we investigate changes to a broad selection of over 10,000,000 immune cells in a cohort of moderate, severe, and critical Japanese COVID-19 patients and healthy controls with a particular focus on regulatory T-cells (Tregs). We find significant disruption within all compartments of the immune system and the emergence of atypical CTLA-4high CD4 T-cells and proliferating HLA-DRlowCD38high Tregs associated with critical patients. We also observed disrupted regulation of humoral immunity in COVID-19, with a loss of circulating T follicular regulatory T cells (Tfr) and altered T follicular helper (Tfh)/Tfr and plasma cell/Tfr ratios, all of which are significantly lower in male patients. Shifting ratios of CXCR4 and CXCR5 expression in B-cells provides further evidence of an autoimmune phenotype and dysregulated humoral immunity. These results suggest that Tregs are central to the changing cellular networks of a wide range of cells in COVID-19 and that sex specific differences to the balance of Tfr, Tfh and plasma cells may have important implications for the specificity of the humoral immune response to SARS-CoV-2.


Author(s):  
Akhileswar Chowdary ◽  
Garima Chopra ◽  
Abhinav Kumar ◽  
Linga Reddy Cenkeramaddi

2022 ◽  
Vol 70 (3) ◽  
pp. 6381-6394
Author(s):  
Tanveer Ahmad ◽  
Imran Khan ◽  
Azeem Irshad ◽  
Shafiq Ahmad ◽  
Ahmed T. Soliman ◽  
...  

Author(s):  
Jaafar A. Aldhaibani ◽  
Mohanad S. Alkhazraji ◽  
Hasanain Lafta Mohammed ◽  
Abid Yaya

High mobility requirements are one of the challenges face fifth-generation wireless (5G) cellular networks by providing acceptable wireless services to users traveling at speed up to 350 km/h. This paper presents a new scenario to increase the bit rate and coverage for passengers that use the vehicles for traveling through the installation a mobile station (MS) on these vehicles to provide a high-quality service to users. Based on signal to noise ratio (SNR’s) mathematical derivation and the outage probability of the user link, the proposed system is evaluated. Numerical results indicate an enhancement for users who received signal strength (RSS) from (-72 to -55) dBm and (15 to 38) Mbps in bit rate. Moreover, their number of users increased by proposed system adoption.


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