The effect of advanced maternal age on maternal and neonatal outcomes of placenta previa: A register-based cohort study

Background: Advanced maternal age is an important predictor for maternal and neonatal outcomes such as maternal mortality, low birth weight, stillbirth, preterm birth, cesarean section and preeclampsia. Objective: To determine the association of advanced maternal age and adverse maternal and neonatal outcomes in Iranian pregnant women. Methods: In this hospital-based cross-sectional study, 5117 pregnant women from 103 hospitals in Tehran, Iran, were participated in the study in 2015. The required data were gathered from hospitals which equipped to the department of obstetrics and gynecology. Advanced maternal age was considered as an independent variable and unwanted pregnancy, preeclampsia, preterm birth, cesarean section and low birth weight were considered as interested outcomes. Results: In our study, the prevalence of advanced maternal age was 12.08%. Advanced maternal age was significantly associated with higher risk of unwanted pregnancy (OR: 1.39, 95% CI: 1.12-1.73), preterm birth (OR: 1.75, 95% CI: 1.28- 2.39) and cesarean section (OR: 1.34, 95% CI: 1.03-1.74). In our study, there was no significant relationship between advanced maternal age and preeclampsia but this relationship could be clinically important (OR: 1.48, 95% CI: 0.99-2.20, P=0.052), and there is no significant relationship between advanced maternal age and low birth weight (OR: 1.08, 95% CI: 0.67-1.74, P=0.736). Conclusion: Advanced maternal age is associated with higher risk of unintended pregnancy, preterm birth and cesarean section but our findings did not support advanced maternal age as a risk factor associated with low birth weight.

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Comparison of Adverse Maternal and Neonatal Outcomes in Women Affected by Placenta Previa With and Without a History of Cesarean Delivery: A Cohort Study

Journal of Obstetrics and Gynaecology Canada ◽

10.1016/j.jogc.2020.12.022 ◽

2021 ◽

Author(s):

Ri-hua Xie ◽

Sihao Zeng ◽

Lepeng Zhou ◽

Suiwen Wen ◽

Yan Liao ◽

...

Keyword(s):

Cohort Study ◽

Cesarean Delivery ◽

Placenta Previa ◽

Neonatal Outcomes ◽

History Of ◽

Maternal And Neonatal Outcomes

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Effect of advanced maternal age on maternal and neonatal outcomes in assisted reproductive technology pregnancies

European Journal of Obstetrics & Gynecology and Reproductive Biology ◽

10.1016/j.ejogrb.2017.07.029 ◽

2017 ◽

Vol 216 ◽

pp. 178-183 ◽

Cited By ~ 5

Author(s):

Amirhossein Moaddab ◽

Frank A. Chervenak ◽

Laurence B. Mccullough ◽

Haleh Sangi-Haghpeykar ◽

Amir A. Shamshirsaz ◽

...

Keyword(s):

Assisted Reproductive Technology ◽

Maternal Age ◽

Advanced Maternal Age ◽

Reproductive Technology ◽

Neonatal Outcomes ◽

Maternal And Neonatal Outcomes

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Influence of Obesity on Maternal and Neonatal Outcomes in Advanced Maternal Age Women [22D]

Obstetrics and Gynecology ◽

10.1097/01.aog.0000663472.60779.74 ◽

2020 ◽

Vol 135 ◽

pp. 44S

Author(s):

Nonda Hanneman ◽

Minhazur Sarker ◽

Aaron B. Caughey ◽

Amy M. Valent

Keyword(s):

Maternal Age ◽

Advanced Maternal Age ◽

Neonatal Outcomes ◽

Maternal And Neonatal Outcomes

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Clinical outcomes of placenta previa with and without coverage of a uterine scar: A retrospective cohort study in a tertiary hospital

10.21203/rs.2.13946/v1 ◽

2019 ◽

Author(s):

Jiaming Rao ◽

Dazhi Fan ◽

Zixing Zhou ◽

Gengdong Chen ◽

Huiting Ma ◽

...

Keyword(s):

Cohort Study ◽

Postpartum Hemorrhage ◽

Retrospective Cohort ◽

Placenta Previa ◽

Fetal Distress ◽

Neonatal Outcomes ◽

Intraoperative Blood Loss ◽

Maternal And Neonatal Outcomes ◽

Uterine Scar ◽

Singleton Pregnancies

Abstract Background To compare the maternal and neonatal outcomes of placenta previa (PP) with and without coverage of a uterine scar in China. Methods A retrospective cohort study comparing all singleton pregnancies with PP was conducted at a tertiary, university-affiliated medical center between January 2012 and April 2017. Maternal and neonatal outcomes of PP with and without coverage of a uterine scar were compared. Results There were 58,062 deliveries during the study period, of which 738 (1.27%) were complicated PP in singleton pregnancies and were further classified into two groups: the PP with coverage of a uterine scar group (PPCS, n=166) and the PP without coverage of a uterine scar group (Non-PPCS, n=572). Overall, the PPCS group had poorer maternal and neonatal outcomes for premature birth (< 37 weeks,68.1% vs 54.8%; P=0.010), cesarean section(100% vs 97.6%; P=0.042), Intraoperative blood loss > 1000 ml (78.3% vs 16.0%; P<0.001) or > 3000ml (29.5% vs 3.0%; P<0.001), postpartum hemorrhage(48.8% vs 15.7%; P<0.001), transfusion (35.2% vs 16.1%; P<0.001), hemorrhage shock(8.4% vs 1.9%; P<0.001), hysterectomy (3.0% vs 0.5%; P=0.006) and fetal distress (36.1% vs 12.0%; P<0.001) than the Non-PPCS group. In pregnancies complicated without abnormal invasive placenta (AIP, n=587), the PPCS group had poorer maternal and neonatal outcomes for Intraoperative blood loss > 1000 ml (69.0% vs 12.5%; P<0.001) or > 3000ml (9.2% vs 1.0%; P<0.001), bleeding within 2-24 hours after delivery (114.7±283.9 vs 47.7±45.1 ml, P<0.001), postpartum hemorrhage (70.1% vs 15.2%, P<0.001), transfusion (28.7% vs 13.6%, P<0.001) and fetal stress (35.6% vs 11.4%, P<0.001) than the Non-PPCS group. Conclusion The PPCS group had poorer maternal and neonatal outcomes than the Non-PPCS group. Women with PPCS were more likely to have intraoperative and postpartum hemorrhage, transfusion and fetal distress, even without AIP.

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The Effect of Very Advanced Maternal Age on Maternal and Neonatal Outcomes: A Systematic Review

Journal of Obstetrics and Gynaecology Canada ◽

10.1016/j.jogc.2017.10.027 ◽

2018 ◽

Vol 40 (9) ◽

pp. 1208-1218 ◽

Cited By ~ 16

Author(s):

Jordana Leader ◽

Amrit Bajwa ◽

Andrea Lanes ◽

Xiaolin Hua ◽

Ruth Rennicks White ◽

...

Keyword(s):

Systematic Review ◽

Maternal Age ◽

Advanced Maternal Age ◽

Neonatal Outcomes ◽

Maternal And Neonatal Outcomes ◽

Very Advanced Maternal Age

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Maternal and neonatal outcomes of placenta previa with and without coverage of a uterine scar: A retrospective cohort study in a tertiary hospital

10.21203/rs.3.rs-31117/v1 ◽

2020 ◽

Author(s):

Jiaming Rao ◽

Dazhi Fan ◽

Zixing Zhou ◽

Gengdong Chen ◽

Pengsheng Li ◽

...

Keyword(s):

Cohort Study ◽

Blood Loss ◽

Retrospective Cohort ◽

Placenta Previa ◽

Fetal Distress ◽

Neonatal Outcomes ◽

Intraoperative Blood Loss ◽

Maternal And Neonatal Outcomes ◽

Uterine Scar ◽

Singleton Pregnancies

Abstract Background To compare the maternal and neonatal outcomes of placenta previa (PP) with and without coverage of a uterine scar in Foshan, China. Methods A retrospective cohort study comparing all singleton pregnancies with PP was conducted at a tertiary, university-affiliated medical center from 1 January 2012 to 31 April 2017 in Foshan, China. Demographic, clinical and laboratory data were extracted from electronic medical records. Maternal and neonatal outcomes of PP with and without coverage of a uterine scar were compared by statistical method. Results There were 58,062 deliveries during the study period, of which 738 (1.27%) were complicated PP in singleton pregnancies and were further classified into two groups: the PP with coverage of a uterine scar group (PPCS, n = 166) and the PP without coverage of a uterine scar group (Non-PPCS, n = 572). Overall, premature birth (< 37 weeks,68.1% vs 54.8%; P = 0.010), cesarean section(100% vs 97.6%; P = 0.042), Intraoperative blood loss > 1000 ml (78.3% vs 16.0%; P < 0.001) or > 3000 ml (29.5% vs 3.0%; P < 0.001), postpartum hemorrhage(48.8% vs 15.7%; P < 0.001), transfusion (35.2% vs 16.1%; P < 0.001), hemorrhage shock(8.4% vs 1.9%; P < 0.001), hysterectomy (3.0% vs 0.5%; P = 0.006) and fetal distress (36.1% vs 12.0%; P < 0.001) had a significant difference between PPCS group and Non-PPCS group. After grouping by whether complicated with AIP, we found that PPCS was significant associated with more intraoperative blood loss༞1000 ml, intraoperative blood loss༞3000 ml, bleeding within 2–24 hours after delivery, fetal distress and higher hospitalization expenses than the Non-PPCS group. After grouping by whether complicated with AIP and different placenta positions(Anterior, Posterior and Ante-posterior or laterally positioned), we found that PPCS was significant associated with more intraoperative blood loss༞1000 ml and higher hospitalization expenses than the Non-PPCS in AIP women and more intraoperative blood loss༞1000 ml, postpartum hemorrhage and higher hospitalization expenses in Non-AIP women. Conclusion The PPCS group had poorer maternal and neonatal outcomes than the Non-PPCS group after grouping by whether pregnancies complicated with AIP or with different placental positions.

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