Xanthan gum to tailor drug release of sustained-release ethylcellulose mini-matrices prepared via hot-melt extrusion: in vitro and in vivo evaluation

2006 ◽  
Vol 63 (3) ◽  
pp. 320-330 ◽  
Author(s):  
E. Verhoeven ◽  
C. Vervaet ◽  
J.P. Remon
Keyword(s):  
Drug Release ◽  
Sustained Release ◽  
Xanthan Gum ◽  
Hot Melt Extrusion ◽  
Melt Extrusion ◽  
In Vivo Evaluation ◽  
Hot Melt

Taste masking of paracetamol by hot-melt extrusion: An in vitro and in vivo evaluation

2012 ◽  
Vol 80 (2) ◽  
pp. 433-442 ◽  
Author(s):  
Mohammed Maniruzzaman ◽  
Joshua S. Boateng ◽  
Marion Bonnefille ◽  
Attila Aranyos ◽  
John C. Mitchell ◽  
...  
Keyword(s):  
Hot Melt Extrusion ◽  
Taste Masking ◽  
Melt Extrusion ◽  
In Vivo Evaluation ◽  
Hot Melt

SUSTAINED RELEASE HYDROPHILIC MATRICES BASED ON XANTHAN GUM AND HYDROXYPROPYL METHYLCELLULOSE: DEVELOPMENT, OPTIMIZATION, IN VITRO AND IN VIVO EVALUATION

2010 ◽  
Vol 2 ◽  
pp. 89-103
Author(s):  
Muhammad Sajid Hamid Akash . ◽  
Ikram Ullah Khan . ◽  
Syed Nisar Hussain Shah . ◽  
Sajid Asghar . ◽  
Asif massud . ◽  
...  
Keyword(s):  
Sustained Release ◽  
Xanthan Gum ◽  
Hydroxypropyl Methylcellulose ◽  
In Vivo Evaluation ◽  
Hydrophilic Matrices

scholarly journals Development of taste masked caffeine citrate formulations utilizing hot melt extrusion technology and in vitro–in vivo evaluations

2015 ◽  
Vol 487 (1-2) ◽  
pp. 167-176 ◽  
Author(s):  
Manjeet B. Pimparade ◽  
Joseph T. Morott ◽  
Jun-Bom Park ◽  
Vijay I. Kulkarni ◽  
Soumyajit Majumdar ◽  
...  
Keyword(s):  
Hot Melt Extrusion ◽  
Melt Extrusion ◽  
Caffeine Citrate ◽  
Extrusion Technology ◽  
Hot Melt

scholarly journals DEVELOPMENT OF TAMOXIFEN CITRATE PELLETS BY HOT-MELT EXTRUSION FOR IMMEDIATE RELEASE: STUDY OF EFFECT OF VARIABLES

2019 ◽  
pp. 111-124
Author(s):  
VISHAL YADAV ◽  
S. SATHESH KUMAR
Keyword(s):  
Drug Release ◽  
Immediate Release ◽  
Hot Melt Extrusion ◽  
Melt Extrusion ◽  
Peg 6000 ◽  
Tamoxifen Citrate ◽  
Croscarmellose Sodium ◽  
Hot Melt ◽  
Mcf 7

Objective: Objective of the study was to develop tamoxifen citrate immediate release pellets by hot-melt extrusion (HME) and to study the effect of various formulation and process variables. Methods: Pellets were prepared by HME technique. Effect of various parameters such as the concentration of ethylcellulose, PEG 6000, croscarmellose sodium, and spheronization speed were studied by using Central Composite Design. Pellets were evaluated for theoretical yield (%), mean pellet size (mm), sphericity (pellips), friability (%), porosity (%), mechanical crushing force (n), and dissolution efficiency. Optimized formulation was studied for compatibility study using IR, DSC, and XRD, SEM, In vitro drug release. In vitro Cell Cytotoxicity and Viability Assay were carried out using MCF-7 (human breast cancer cells) by MTT assay. Results: Results showed that a variable such as the amount of Methyl Cellulose, PEG 6000 and Spheronization speed showed positive correlation and amount of Croscarmellose sodium showed a negative correlation with dependent variables. Optimized formulation showed Korsmeyer Peppas model as a mechanism of drug release. Value of n was found to be in between 0.77+0.04, which reveals that, release mechanism of the drug as non-Fickian transport (0.45<n<0.89). MTT results of MCF-7 cells showed that optimized immediate release pellets have maximum cytotoxicity at 80 µg/ml. Conclusion: Study concluded that HME method and materials i.e. PEG 6000 and methylcellulose can effectively use to get immediate release of tamoxifen citrate so as to increase dissolution rate and cytotoxic effect.

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