Development and in vitro evaluation of pressure sensitive adhesive patch for the transdermal delivery of galantamine: Effect of penetration enhancers and crystallization inhibition

2019 ◽  
Vol 139 ◽  
pp. 262-271 ◽  
Author(s):  
Dina Ameen ◽  
Bozena Michniak-Kohn
Keyword(s):  
Transdermal Delivery ◽  
Penetration Enhancers ◽  
Pressure Sensitive Adhesive ◽  
In Vitro Evaluation ◽  
Pressure Sensitive ◽  
Crystallization Inhibition ◽  
Adhesive Patch

scholarly journals Effect of Different Pressure-Sensitive Adhesives on Performance Parameters of Matrix-Type Transdermal Delivery Systems

Pharmaceutics ◽  
2020 ◽  
Vol 12 (3) ◽  
pp. 209 ◽  
Author(s):  
Behnam Dasht Bozorg ◽  
Ajay K. Banga
Keyword(s):  
Transdermal Delivery ◽  
Drug Loading ◽  
In Vitro Release ◽  
Systemic Circulation ◽  
Delivery Systems ◽  
Pressure Sensitive Adhesive ◽  
Matrix Type ◽  
Pressure Sensitive ◽  
Percentage Release

Matrix-type transdermal delivery systems (TDS) are comprised of the drug dissolved or dispersed in a pressure-sensitive adhesive (PSA) matrix and are designed to provide a controlled delivery through the skin and into systemic circulation. PSAs can directly affect the permeation, release, and performance characteristics of the system. In this study we aimed to design and characterize transdermal delivery systems formulated with lidocaine—as the model drug—loaded in different PSAs, including silicone, polyisobutylene (PIB), and acrylate. TDS containing lidocaine at its saturation points were prepared by the solvent casting method. In vitro permeation studies across dermatomed porcine ear skin were performed using Franz diffusion cells. In vitro release studies were carried out using USP apparatus 5 (paddle over disk). The cumulative amount permeated from the acrylate was significantly higher than silicone and PIB. The acrylate TDS contained a ten times higher drug amount than silicone TDS, but the permeation flux was only two folds higher. Results also showed the release of drug does not linearly correlate to saturation, as the silicone TDS comprising of the lowest amount of drug loading, showed the highest percentage release indicating the choice of PSA affected the drug release and permeation profile.

Transdermal Delivery of Targeted Nanoparticles and in vitro Evaluation

2021 ◽  
pp. 411-443
Author(s):  
Ceyda Ekentok Atıcı ◽  
Aysun Çelik Soysal ◽  
Ali Demir Sezer
Keyword(s):  
Transdermal Delivery ◽  
In Vitro Evaluation ◽  
Targeted Nanoparticles
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