Strain differences in paroxetine-induced reduction of immobility time in the forced swimming test in mice: Role of serotonin

2008 ◽  
Vol 594 (1-3) ◽  
pp. 117-124 ◽  
Author(s):  
Sara Guzzetti ◽  
Eleonora Calcagno ◽  
Alessandro Canetta ◽  
Giuseppina Sacchetti ◽  
Claudia Fracasso ◽  
...  
Keyword(s):  
Forced Swimming Test ◽  
Strain Differences ◽  
Forced Swimming ◽  
Immobility Time ◽  
Swimming Test

scholarly journals Adenylyl Cyclase (AC) Mediates the Antidepressant-Like Effects of Tropisetron on a Mouse Model of Maternal Separation Stress

2021 ◽  
Vol 2021 ◽  
pp. 1-6
Author(s):  
Ali Hosseinzadeh ◽  
Shakiba Nasiri Boroujeni ◽  
Elham Saghaei ◽  
Zahra Loriooini ◽  
Saeid Habibian Dehkordi ◽  
...  
Keyword(s):  
Effective Dose ◽  
Adenylyl Cyclase ◽  
Maternal Separation ◽  
Forced Swimming Test ◽  
Forced Swimming ◽  
Control Group ◽  
Immobility Time ◽  
Swimming Test ◽  
Medicinal Properties

The adenylyl cyclase (AC) pathway is involved in the pathophysiology of depression. Finding new antidepressants with high medicinal properties and low side effects is warranted. Therefore, this study was designed to determine the antidepressant-like effect of tropisetron on a maternal separation (MS) model in mice, considering the possible role of AC. NMRI male mice were divided into eleven groups. The control group was treated with saline and MS groups were treated with saline, tropisetron (a 5-HT3 receptor antagonist) at doses of 1, 3, and 5 mg/kg; forskolin (an activator of AC) at doses of 5, 10, and 25 mg/kg; a subeffective dose of forskolin with a subeffective dose of tropisetron; and an effective dose of tropisetron plus an effective dose of NB001 (3 mg/kg) (an AC inhibitor). After treatment, animals were subjected to behavioral tests including the forced swimming test (FST), splash test, and open field test (OFT). We showed that MS caused depressive-like behaviors determined as an increase in the immobility time in the forced swimming test (FST) and decreased grooming time in the splash test. Our results showed that administration of tropisetron, as well as forskolin, mitigated the depressive-like behaviors in MS mice. We found that coadministration of a subeffective dose of tropisetron plus a subeffective dose of forskolin potentiated the antidepressant-like effect of tropisetron. However, coadministration of an effective dose of NB001 with an effective dose of tropisetron did not significantly affect the antidepressant-like effect of tropisetron. We concluded that the antidepressant-like effects of tropisetron on MS mice are partially mediated through the adenylyl cyclase pathway.

Role of genotype and dopamine receptors in behaviour of inbred mice in a forced swimming test

1991 ◽  
Vol 105 (4) ◽  
pp. 525-529 ◽  
Author(s):  
Ella M. Nikulina ◽  
Julia A. Skrinskaya ◽  
Nina K. Popova
Keyword(s):  
Dopamine Receptors ◽  
Forced Swimming Test ◽  
Inbred Mice ◽  
Forced Swimming ◽  
Swimming Test

Antidepressant-like effect of pioglitazone in the forced swimming test in mice: The role of PPAR-gamma receptor and nitric oxide pathway

2011 ◽  
Vol 224 (2) ◽  
pp. 336-343 ◽  
Author(s):  
Mohammad Salehi Sadaghiani ◽  
Mehrak Javadi-Paydar ◽  
Mohammad Hadi Gharedaghi ◽  
Yashar Yousefzadeh Fard ◽  
Ahmad Reza Dehpour
Keyword(s):  
Nitric Oxide ◽  
Forced Swimming Test ◽  
Ppar Gamma ◽  
Forced Swimming ◽  
Gamma Receptor ◽  
Swimming Test ◽  
Nitric Oxide Pathway

Role of different types of potassium channels in the antidepressant-like effect of agmatine in the mouse forced swimming test

2007 ◽  
Vol 575 (1-3) ◽  
pp. 87-93 ◽  
Author(s):  
Josiane Budni ◽  
Vinícius M. Gadotti ◽  
Manuella P. Kaster ◽  
Adair R.S. Santos ◽  
Ana Lúcia S. Rodrigues
Keyword(s):  
Potassium Channels ◽  
Forced Swimming Test ◽  
Forced Swimming ◽  
Different Types ◽  
Swimming Test

Antidepressant-like effect of a Ginkgo biloba extract (EGb761) in the mouse forced swimming test: Role of oxidative stress

2011 ◽  
Vol 59 (5) ◽  
pp. 628-636 ◽  
Author(s):  
Patricia Rojas ◽  
Norma Serrano-García ◽  
Omar N. Medina-Campos ◽  
José Pedraza-Chaverri ◽  
Sven O. Ögren ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Ginkgo Biloba ◽  
Forced Swimming Test ◽  
Ginkgo Biloba Extract ◽  
Forced Swimming ◽  
Swimming Test
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