In vitro and in vivo characterization of Lu AA41178: A novel, brain penetrant, pan-selective Kv7 potassium channel opener with efficacy in preclinical models of epileptic seizures and psychiatric disorders

2020 ◽  
Vol 887 ◽  
pp. 173440
Author(s):  
Morten Grupe ◽  
Bo Hjorth Bentzen ◽  
Tau Benned-Jensen ◽  
Vibeke Nielsen ◽  
Kristen Frederiksen ◽  
...  
Keyword(s):  
Potassium Channel ◽  
Psychiatric Disorders ◽  
Epileptic Seizures ◽  
Potassium Channel Opener ◽  
Preclinical Models ◽  
Channel Opener ◽  
In Vivo Characterization

Effects of the New Potassium Channel Opener JTV-506 on Coronary Vessels in vitro and in vivo

2011 ◽  
Vol 49 (03) ◽  
pp. 199-206
Author(s):  
Yukiya Hirata ◽  
Atsunori Kanada ◽  
Hisato Miyai ◽  
Yukiyo Mabuchi ◽  
Kazuo Aisaka
Keyword(s):  
Potassium Channel ◽  
Coronary Vessels ◽  
Potassium Channel Opener ◽  
Channel Opener

The Synthesis and Use of BMS 204352 (MaxiPostTM)

2020 ◽  
Vol 17 (1) ◽  
pp. 67-73
Author(s):  
Renato Dalpozzo
Keyword(s):  
Potassium Channel ◽  
The State ◽  
Synthetic Methods ◽  
Potassium Channel Opener ◽  
Research Fields ◽  
Channel Opener ◽  
In Vivo Tests ◽  
State Of Art

MaxiPostTM is an interesting 3-fluorooxindole derivative, discovered in the late nineties of the last century as potassium channel opener. Since then, two different research fields were discovered: the discovery of new synthetic methods, especially asymmetric ones, and the in vitro and in vivo tests for its use as a drug for different diseases. This mini-review aims to summarize the state of art in both fields.

scholarly journals In vitro and in vivo characterization of a novel naphthylamide ATP-sensitive K+ channel opener, A-151892

2004 ◽  
Vol 143 (1) ◽  
pp. 81-90 ◽  
Author(s):  
Murali Gopalakrishnan ◽  
Steven A Buckner ◽  
Char-Chang Shieh ◽  
Thomas Fey ◽  
Adebola Fabiyi ◽  
...  
Keyword(s):  
K Channel ◽  
Channel Opener ◽  
In Vivo Characterization ◽  
K Channel Opener

Airway pharmacology of the potassium channel opener, HOE 234, in guinea pigs: in vitro and in vivo studies

1992 ◽  
Vol 210 (1) ◽  
pp. 69-75 ◽  
Author(s):  
Heinrich C. Englert ◽  
Klaus Wirth ◽  
Doris Gehring ◽  
Ute Fürst ◽  
Udo Albus ◽  
...  
Keyword(s):  
Potassium Channel ◽  
Guinea Pigs ◽  
In Vivo Studies ◽  
Potassium Channel Opener ◽  
Channel Opener

EFFECTS OF THE POTASSIUM CHANNEL OPENER AND NITRIC OXIDE DONOR NICORANDIL ON THE URETER MOTILITY OF PIGS IN VITRO AND IN VIVO

1999 ◽  
pp. 86
Author(s):  
Hansjorg Danuser ◽  
Ruth Weiss ◽  
Meike Mevissen ◽  
Daniela Abel ◽  
Gunter Scholtysik ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Potassium Channel ◽  
Nitric Oxide Donor ◽  
Potassium Channel Opener ◽  
Channel Opener

In vitro and in vivo characterization of graphene oxide coated porcine bone granules

Carbon ◽  
2016 ◽  
Vol 103 ◽  
pp. 291-298 ◽  
Author(s):  
Valeria Ettorre ◽  
Patrizia De Marco ◽  
Susi Zara ◽  
Vittoria Perrotti ◽  
Antonio Scarano ◽  
...  
Keyword(s):  
Graphene Oxide ◽  
In Vivo Characterization
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