Analgesic effects of cuminic alcohol (4-isopropylbenzyl alcohol), a monocyclic terpenoid, in animal models of nociceptive and neuropathic pain: Role of opioid receptors, L-arginine/NO/cGMP pathway, and inflammatory cytokines

2021 ◽  
pp. 174075
Author(s):  
Mohammad Abbas Sheikholeslami ◽  
Shiva Ghafghazi ◽  
Siavash Parvardeh ◽  
Sheida Koohsari ◽  
Saeed Haji Aghajani ◽  
...  
Keyword(s):  
Neuropathic Pain ◽  
Animal Models ◽  
Inflammatory Cytokines ◽  
Opioid Receptors ◽  
Analgesic Effects ◽  
Cgmp Pathway

scholarly journals Analgesic Effects of the Cressa Cretica Extract on Induced Neuropathic Pain in Rats, and the Potential Role of Opioid Receptors

2021 ◽  
Vol 15 (4) ◽  
pp. 241-248
Author(s):  
Mohsen Zabihi ◽  
◽  
Ali Mohammad Ranjbar ◽  
Mohammad Hossein Mosaddegh ◽  
Nasrin Zare ◽  
...  
Keyword(s):  
Neuropathic Pain ◽  
Opioid Receptors ◽  
Sensory Nerve ◽  
Total Phenolic ◽  
Behavioral Tests ◽  
Hydroalcoholic Extract ◽  
Analgesic Effects ◽  
Central Neurons ◽  
Phenolic And Flavonoid

Background: Damages to the peripheral fibers of sensory nerve cells and central neurons cause neuropathic pain. Manifestations of neuropathic pain occur in various conditions, including diabetes mellitus, chemotherapy, and as the side effects of some medications. Cressa cretica has long been used in traditional medicine for pain control. This study was conducted to determine the role of opioid receptors in the analgesic effect of the hydroalcoholic extract of C. cretica in an experimental model of neuropathic pain. Methods: The hydroalcoholic extract of C. cretica was prepared, and its total phenolic and flavonoid contents were standardized. Painful peripheral neuropathy was induced in rats by Chronic Constriction Injury (CCI) of the sciatic nerve. To evaluate the effects of the extract, the animals were orally given C. cretica extract (300 mg/kg), gabapentin (70 mg/kg) or normal saline (4 mL/kg) on days 3, 7, 14, and 21 after surgery, and behavioral tests were performed 45 minutes after taking the medications. To evaluate the role of the opioid receptors, Naloxone (1 mg/kg, IP) was given to rats treated with the extract 30 minutes after the extract and then the behavioral tests were performed after 15 minutes. Results: The hydroalcoholic extract of C. cretica attenuates neuropathic pain induced by CCI in rats. The extract works acutely and chronically, depending on the dosage and duration of use. Conclusion: The hydroalcoholic extract of C. cretica reduces CCI-induced neuropathic pain in rats, and Naloxone, as an opioid receptor antagonist, inhibits this effect.

The role of brain-derived neurotrophic factor in different animal models of neuropathic pain

2010 ◽  
Vol 14 (5) ◽  
pp. 473.e1-473.e9 ◽  
Author(s):  
Pascal Vanelderen ◽  
Tom Rouwette ◽  
Tamas Kozicz ◽  
Eric Roubos ◽  
Jan Van Zundert ◽  
...  
Keyword(s):  
Neuropathic Pain ◽  
Animal Models ◽  
Neurotrophic Factor ◽  
Brain Derived Neurotrophic Factor

scholarly journals Complex Regional Pain Syndrome (CRPS/RSD) and Neuropathic Pain: Role of Intravenous Bisphosphonates as Analgesics

2008 ◽  
Vol 8 ◽  
pp. 229-236 ◽  
Author(s):  
Jennifer Yanow ◽  
Marco Pappagallo ◽  
Letha Pillai
Keyword(s):  
Clinical Trials ◽  
Neuropathic Pain ◽  
Animal Models ◽  
Complex Regional Pain Syndrome ◽  
Bone Pain ◽  
Treatment Options ◽  
Pain Syndrome ◽  
Pain Pathways ◽  
Intravenous Bisphosphonates

Neuropathic pain is a sequela of dysfunction, injuries, or diseases of the peripheral and/or central nervous system pain pathways, which has historically been extremely difficult to treat. Complex regional pain syndrome (CRPS) types 1 and 2 are neuropathic pain conditions that have a long history in the medical literature but whose pathophysiology remains elusive and whose available treatment options remain few. While an exact animal model for CRPS doesn't yet exist, there are several animal models of neuropathic pain that develop behaviors of hypersensitivity, one of the hallmark signs of neuropathic pain in humans.Bisphosphonates have been used for pathologic conditions associated with abnormal bone metabolism, such as osteoporosis, Paget’s disease and cancer-related bone pain for many years. More recently, results of clinical trials have indicated the potential role of bisphosphonates in the treatment of CRPS/RSD.In this paper we will review the preclinical studies regarding the use of bisphosphonates as analgesics in animal models of neuropathic pain, and also summarize the clinical trials that have been done to date. We will give an overview of bisphosphonate pharmacology and discuss several potential mechanisms by which bisphosphonates may be analgesic in CRPS/RSD and bone pain of noncancer origin.

scholarly journals Role of Peripheral Sensory Neuron mu-Opioid Receptors in Nociceptive, Inflammatory, and Neuropathic Pain

2020 ◽  
Author(s):  
Awinita Barpujari ◽  
Neil Ford ◽  
Shaoqiu He ◽  
Qian Huang ◽  
Claire Gaveriaux Ruff ◽  
...  
Keyword(s):  
Neuropathic Pain ◽  
Sensory Neuron ◽  
Opioid Receptors ◽  
Mu Opioid Receptors ◽  
Mu Opioid ◽  
Peripheral Sensory

scholarly journals Evaluation of calcium-sensitive adenylyl cyclase AC1 and AC8 mRNA expression in the anterior cingulate cortex of mice with neuropathic pain

2021 ◽  
Author(s):  
Stephanie Shiers ◽  
Hajira Elahi ◽  
Stephanie Hennen ◽  
Theodore J Price
Keyword(s):  
Neuropathic Pain ◽  
Animal Models ◽  
Mrna Expression ◽  
Anterior Cingulate Cortex ◽  
Nerve Injury ◽  
Visceral Pain ◽  
Cingulate Cortex ◽  
Anterior Cingulate ◽  
Mechanical Hypersensitivity

AbstractThe anterior cingulate cortex (ACC) is a critical region of the brain for the emotional and affective components of pain in rodents and humans. Hyperactivity in this region has been observed in neuropathic pain states in both patients and animal models and ablation of this region from cingulotomy, or inhibition with genetics or pharmacology can diminish pain and anxiety. Two adenylyl cyclases (AC), AC1 and AC8 play an important role in regulating nociception and anxiety-like behaviors through an action in the ACC, as genetic and pharmacological targeting of these enzymes reduces mechanical hypersensitivity and anxietylike behavior, respectively. However, the distribution of these ACs in the ACC has not been studied in the context of neuropathic pain. To address this gap in knowledge, we conducted RNAscope in situ hybridization to assess AC1 and AC8 mRNA distribution in mice with spared nerve injury (SNI). Given the key role of AC1 in nociception in neuropathic, inflammatory and visceral pain animal models, we hypothesized that AC1 would be upregulated in the ACC of mice following nerve injury. This hypothesis was also founded on data showing increased AC1 expression in the ACC of mice with zymosan-induced visceral inflammation. We found that AC1 and AC8 are widely expressed in many regions of the mouse brain including the hippocampus, ACC, medial prefrontal cortex and midbrain regions, but AC1 is more highly expressed. Contrary to our hypothesis, SNI causes an increase in AC8 mRNA expression in NMDAR-2B (Nr2b) positive neurons in the contralateral ACC but does not affect AC1 mRNA expression. Our findings show that changes in Adcy1 mRNA expression in the ACC are insufficient to explain the important role of this AC in mechanical hypersensitivity in mice following nerve injury and suggest a potential unappreciated role of AC8 in regulation of ACC synaptic changes after nerve injury.

Analgesic Effects of Huwentoxin-IV on Animal Models of Inflammatory and Neuropathic Pain

2013 ◽  
Vol 21 (2) ◽  
pp. 153-158 ◽  
Author(s):  
Yu Liu ◽  
Zhe Wu ◽  
Dongfang Tang ◽  
Xiaohong Xun ◽  
Lichao Liu ◽  
...  
Keyword(s):  
Neuropathic Pain ◽  
Animal Models ◽  
Analgesic Effects

Animal Models of Peripheral Neuropathy and Neuropathic Pain

2017 ◽  
Author(s):  
Katelyn Donaldson ◽  
Ahmet Höke
Keyword(s):  
Neuropathic Pain ◽  
Peripheral Neuropathy ◽  
Animal Models ◽  
Human Disease ◽  
New Drugs ◽  
Molecular Pathways ◽  
Peripheral Neuropathies ◽  
Different Types

There are numerous types of peripheral neuropathies and conditions that cause neuropathic pain with varying symptoms and different mechanisms of pathogenesis. Therefore, it is not surprising that many different animal models of peripheral neuropathies and neuropathic pain have been developed with varying degrees of fidelity to recapitulate the human disease. Nevertheless, these models are useful in a deconstructive manner to examine role of specific molecular pathways in pathogenesis of different types of peripheral neuropathies and test potential new drugs.

The role of pro-inflammatory cytokines in cancer treatment-induced alimentary tract mucositis: Pathobiology, animal models and cytotoxic drugs

2007 ◽  
Vol 33 (5) ◽  
pp. 448-460 ◽  
Author(s):  
Richard M. Logan ◽  
Andrea M. Stringer ◽  
Joanne M. Bowen ◽  
Ann S.-J. Yeoh ◽  
Rachel J. Gibson ◽  
...  
Keyword(s):  
Animal Models ◽  
Cancer Treatment ◽  
Inflammatory Cytokines ◽  
Alimentary Tract ◽  
Cytotoxic Drugs ◽  
Pro Inflammatory Cytokines
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