scholarly journals Clinical significance of interferon lambda-3 (IFNλ3)/interleukin 28B (IL28B) in systemic lupus erythematosus patients

2022 ◽  
Vol 44 (2) ◽  
pp. 121-125
Author(s):  
Fatma H. Abdelraouf ◽  
Manal E.S. Ramadan ◽  
Dina O. Abdulazim ◽  
AliGenena ◽  
Heba M. Selim
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Clinical Significance ◽  
Lupus Erythematosus ◽  
Systemic Lupus ◽  
Interleukin 28B ◽  
Interferon Lambda ◽  
Interferon Lambda 3

scholarly journals The Expression and Clinical Significance of Different Forms of Mer Receptor Tyrosine Kinase in Systemic Lupus Erythematosus

2014 ◽  
Vol 2014 ◽  
pp. 1-12 ◽  
Author(s):  
Huaqun Zhu ◽  
Xiaolin Sun ◽  
Lei Zhu ◽  
Fanlei Hu ◽  
Lianjie Shi ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Disease Activity ◽  
Clinical Significance ◽  
Receptor Tyrosine Kinase ◽  
Lupus Erythematosus ◽  
Healthy Subjects ◽  
Mrna Levels ◽  
Systemic Lupus ◽  
Real Time Quantitative Pcr ◽  
Cd163 Expression

Objective. To investigate the expression and clinical significance of trans-membrane MerTK (mMer) on circulating CD14+ monocytes/macrophages and soluble MerTK (sMer) levels in plasma in systemic lupus erythematosus (SLE).Method. 108 SLE patients and 42 healthy controls were recruited in this study. The expression of mMer on the surfaces of CD14+ monocytes/macrophages was evaluated by flow cytometry (FCM). The sMer levels were measured by ELISA. Real-time quantitative PCR was applied to evaluate the mRNA levels of MerTK and ADAM17.Results. Both mMer expression on CD14+ monocytes/macrophages and sMer levels in plasma significantly increased in SLE patients compared to healthy subjects. The frequency of anti-inflammatory MerTK expressing CD14+CD16+ monocytes decreased in SLE. mMer expression was positively correlated with CD163 expression on CD14+ cells. Both the mMer expression on CD14+ monocytes/macrophages and sMer levels in plasma were positively correlated with SLEDAI. Furthermore, more elevated mMer and sMer levels were found in patients with higher SLEDAI, presence of anti-SSA, anti-Sm autoantibodies, and lupus nephritis.Conclusion. Both mMer and sMer levels significantly increased in SLE and positively correlated with disease activity and severity. The upregulation of MerTK expression may serve as a biomarker of the disease activity and severity of SLE.

Clinical Significance of Autoantibodies in Systemic Lupus Erythematosus

Rheumatology ◽  
1994 ◽  
Vol 33 (12) ◽  
pp. 1202-1203 ◽  
Author(s):  
M. HIETARINTA ◽  
M. VIANDER ◽  
A. TOIVANEN ◽  
O. LASSILA
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Clinical Significance ◽  
Lupus Erythematosus ◽  
Systemic Lupus

scholarly journals AB0567 Clinical significance of the detection of hla-drb1 alleles in patients with systemic lupus erythematosus

2018 ◽  
Author(s):  
E. Belolipetskaia ◽  
I. Beliaeva ◽  
V. Mazurov ◽  
S. Lapin ◽  
O. Tkachenko ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Clinical Significance ◽  
Lupus Erythematosus ◽  
Systemic Lupus

Clinical significance of anti-annexin V antibodies in patients with systemic lupus erythematosus

1997 ◽  
Vol 54 (3) ◽  
pp. 209-213 ◽  
Author(s):  
Junichi Kaburaki ◽  
Masataka Kuwana ◽  
Mihoko Yamamoto ◽  
Shinichi Kawai ◽  
Yasuo Ikeda
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Clinical Significance ◽  
Lupus Erythematosus ◽  
Annexin V ◽  
Systemic Lupus
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