Brain tumor perfusion: Comparison of dynamic contrast enhanced magnetic resonance imaging using T1, T2, and contrast, pulsed arterial spin labeling, and H215O positron emission tomography

2009 ◽  
Vol 70 (3) ◽  
pp. 465-474 ◽  
Author(s):  
Lutz Lüdemann ◽  
Carsten Warmuth ◽  
Michail Plotkin ◽  
Annette Förschler ◽  
Matthias Gutberlet ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Positron Emission Tomography ◽  
Arterial Spin Labeling ◽  
Spin Labeling ◽  
Emission Tomography ◽  
Tumor Perfusion ◽  
Resonance Imaging ◽  
Dynamic Contrast Enhanced ◽  
Positron Emission ◽  
Contrast Enhanced

scholarly journals Using Dynamic Contrast-Enhanced Magnetic Resonance Imaging Data to Constrain a Positron Emission Tomography Kinetic Model: Theory and Simulations

2013 ◽  
Vol 2013 ◽  
pp. 1-9 ◽  
Author(s):  
Jacob U. Fluckiger ◽  
Xia Li ◽  
Jennifer G. Whisenant ◽  
Todd E. Peterson ◽  
John C. Gore ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Positron Emission Tomography ◽  
Emission Tomography ◽  
Dynamic Pet ◽  
Resonance Imaging ◽  
Dce Mri ◽  
Dynamic Contrast Enhanced ◽  
Positron Emission ◽  
Contrast Enhanced ◽  
True Values

We show how dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) data can constrain a compartmental model for analyzing dynamic positron emission tomography (PET) data. We first develop the theory that enables the use of DCE-MRI data to separate whole tissue time activity curves (TACs) available from dynamic PET data into individual TACs associated with the blood space, the extravascular-extracellular space (EES), and the extravascular-intracellular space (EIS). Then we simulate whole tissue TACs over a range of physiologically relevant kinetic parameter values and show that using appropriate DCE-MRI data can separate the PET TAC into the three components with accuracy that is noise dependent. The simulations show that accurate blood, EES, and EIS TACs can be obtained as evidenced by concordance correlation coefficients >0.9 between the true and estimated TACs. Additionally, provided that the estimated DCE-MRI parameters are within 10% of their true values, the errors in the PET kinetic parameters are within approximately 20% of their true values. The parameters returned by this approach may provide new information on the transport of a tracer in a variety of dynamic PET studies.

scholarly journals Comparison of Cerebral Blood Flow Acquired by Simultaneous [15O]Water Positron Emission Tomography and Arterial Spin Labeling Magnetic Resonance Imaging

2014 ◽  
Vol 34 (8) ◽  
pp. 1373-1380 ◽  
Author(s):  
Ke Zhang ◽  
Hans Herzog ◽  
Jörg Mauler ◽  
Christian Filss ◽  
Thomas W Okell ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Positron Emission Tomography ◽  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Magnetic Resonance ◽  
Arterial Spin Labeling ◽  
Spin Labeling ◽  
Emission Tomography ◽  
Resonance Imaging ◽  
Positron Emission

Until recently, no direct comparison between [15O]water positron emission tomography (PET) and arterial spin labeling (ASL) for measuring cerebral blood flow (CBF) was possible. With the introduction of integrated, hybrid magnetic resonance (MR)-PET scanners, such a comparison becomes feasible. This study presents results of CBF measurements recorded simultaneously with [15O]water and ASL. A 3T MR-BrainPET scanner was used for the simultaneous acquisition of pseudo-continuous ASL (pCASL) magnetic resonance imaging (MRI) and [15O]water PET. Quantitative CBF values were compared in 10 young healthy male volunteers at baseline conditions. A statistically significant ( P<0.05) correlation was observed between the two modalities; the whole-brain CBF values determined with PET and pCASL were 43.3 ±6.1 mL and 51.9 ± 7.1 mL per 100 g per minute, respectively. The gray/white matter (GM/WM) ratio of CBF was 3.0 for PET and 3.4 for pCASL. A paired t-test revealed differences in regional CBF between ASL and PET with higher ASL-CBF than PET-CBF values in cortical areas. Using an integrated, hybrid MR-PET a direct simultaneous comparison between ASL and [15O]water PET became possible for the first time so that temporal, physiologic, and functional variations were avoided. Regional and individual differences were found despite the overall similarity between ASL and PET, requiring further detailed investigations.

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