101. Prognostic value of lymph node ratio in locally advanced rectal cancer patients after preoperative radiotherapy 25 Gy followed by total mesorectal excision (TME) – Results from randomized trial

2016 ◽  
Vol 42 (9) ◽  
pp. S108
Author(s):  
R. Pach ◽  
P. Richter ◽  
J. Kulig
Keyword(s):  
Rectal Cancer ◽  
Lymph Node ◽  
Prognostic Value ◽  
Lymph Node Ratio ◽  
Preoperative Radiotherapy ◽  
Locally Advanced ◽  
Advanced Rectal Cancer ◽  
Locally Advanced Rectal Cancer ◽  
Mesorectal Excision ◽  
Node Ratio

scholarly journals Prognostic value of lymph node ratio in survival of patients with locally advanced rectal cancer

2015 ◽  
Vol 58 (4) ◽  
pp. 237-244 ◽  
Author(s):  
Di Zhou ◽  
Ming Ye ◽  
Yongrui Bai ◽  
Ling Rong ◽  
Yanli Hou
Keyword(s):  
Rectal Cancer ◽  
Lymph Node ◽  
Prognostic Value ◽  
Lymph Node Ratio ◽  
Locally Advanced ◽  
Advanced Rectal Cancer ◽  
Locally Advanced Rectal Cancer ◽  
Node Ratio

2050 Impact of lymph node ratio in locally advanced rectal cancer

2015 ◽  
Vol 51 ◽  
pp. S345
Author(s):  
A. Freire Coelho ◽  
S. Povoa ◽  
C. Rey ◽  
C. Sarmento ◽  
M. Marques ◽  
...  
Keyword(s):  
Rectal Cancer ◽  
Lymph Node ◽  
Lymph Node Ratio ◽  
Locally Advanced ◽  
Advanced Rectal Cancer ◽  
Locally Advanced Rectal Cancer ◽  
Node Ratio

scholarly journals Prognostic Value of the Distribution of Lymph Node Metastasis in Locally Advanced Rectal Cancer After Neoadjuvant Chemoradiotherapy

2021 ◽  
Vol 8 ◽  
Author(s):  
Bin Chen ◽  
Xing Liu ◽  
Yiyi Zhang ◽  
Jinfu Zhuang ◽  
Yong Peng ◽  
...  
Keyword(s):  
Rectal Cancer ◽  
Lymph Node ◽  
Prognostic Factor ◽  
Lymph Node Metastasis ◽  
Prognostic Value ◽  
Locally Advanced ◽  
Neoadjuvant Chemoradiotherapy ◽  
Advanced Rectal Cancer ◽  
Locally Advanced Rectal Cancer ◽  
Node Metastasis

Background: The objective of this study is to assess the prognostic value of lymph node metastasis distribution (LND) in locally advanced rectal cancer (LARC) after neoadjuvant chemoradiotherapy (nCRT).Methods: This study included 179 patients with pathological stage III LARC who underwent nCRT followed by radical surgery. LND was classified into three groups: LND1, lymph node metastasis at the mesorectum (140/179, 78.2%); LND2, lymph node metastasis along the inferior mesenteric artery trunk nodes (26/179, 14.5%); LND3, lymph node metastasis at the origin of the IMA (13/179, 7.3%). Clinicopathologic characteristics were analyzed to identify independent prognostic factors.Result: LND showed better stratification for 3-year DFS (LND1 66.8, LND2 50, and LND3 15.4%, P < 0.01) compared to the ypN (3-year DFS: N1 59.9 and N2 60.3%, P = 0.34) and ypTNM (3-year DFS: IIIA 68.6%, IIIB 57.5%, and IIIC 53.5, P = 0.19) staging systems. Similar results were found for 3-year LRFS and DMFS. According to multivariate survival analysis, LND was shown to be an independent prognostic factor for DFS, LRFS, and DMFS in patients with positive lymph nodes (P < 0.01, in all cases).Conclusion: LND is an independent prognostic factor in stage III rectal cancer after nCRT. LND can be used as a supplementary indicator for the ypTNM staging system in patients with LARC after nCRT.

Prognostic value of lymph node yield in locally advanced rectal cancer with neoadjuvant chemoradiotherapy.

2018 ◽  
Vol 36 (15_suppl) ◽  
pp. e15680-e15680 ◽  
Author(s):  
Yaqi Wang ◽  
Menglong Zhou ◽  
Lifeng Yang ◽  
Jing Zhang ◽  
Weijuan Deng ◽  
...  
Keyword(s):  
Rectal Cancer ◽  
Lymph Node ◽  
Prognostic Value ◽  
Locally Advanced ◽  
Neoadjuvant Chemoradiotherapy ◽  
Advanced Rectal Cancer ◽  
Locally Advanced Rectal Cancer ◽  
Lymph Node Yield ◽  
Node Yield

Prognostic value of the number of retrieved lymph node and lymph node ratio in locally advanced rectal cancer after preoperative radiation therapy.

2014 ◽  
Vol 32 (3_suppl) ◽  
pp. 582-582
Author(s):  
Jin-hong Park ◽  
Young Seob Shin ◽  
Eun Kyung Choi ◽  
Seung Do Ahn ◽  
Sang Min Yoon ◽  
...  
Keyword(s):  
Rectal Cancer ◽  
Radiation Therapy ◽  
Lymph Node ◽  
Prognostic Value ◽  
Locally Advanced ◽  
Advanced Rectal Cancer ◽  
Locally Advanced Rectal Cancer ◽  
Preoperative Radiation ◽  
Node Negative ◽  
Preoperative Radiation Therapy

582 Background: To assess the prognostic impact of total number of retrieved lymph node (TNN) and lymph node radio (LNR) in patients with locally advanced rectal cancer who received preoperative radiation therapy and surgery Methods: We retrospectively analyzed data from 677 patients with locally advanced rectal cancer who underwent preoperative radiation therapy followed by mesorectal excision at Asan Medical Center between October 1999 and May 2009. The median radiation dose was 50 Gy, and 674 patients (99%) underwent concurrent chemotherapy. All patients were divided into two groups according to the status of lymph node involvement. We assessed the influence of TNN on overall survival (OS) and disease-free survival (DFS) in the patients with node-negative disease (pN0, n = 490), and the prognostic value of LNR, estimated by dividing the number of positive nodes by the number of lymph nodes examined, in the patients with node-positive disease (pN1-2, n = 187). Results: The median follow-up period was 74 months.Patients with pN0 had median 12 lymph nodes examined (range, 0-38). Comparing with patients who had ≤ 8 TNN, patients with > 9 TNN had significantly higher 5-year OS (89% vs. 95%, p = 0.038) and DFS rates (81% vs. 90%, p = 0.013). Multivariate analysis showed that TNN more than 9 was significant prognostic factor for OS (p = 0.032) and DFS (p = 0.007). For patients with pN1-2, patients with low LNR (≤ 0.33, n = 144) showed significantly higher 5-year OS (33% vs. 73%, p < 0.001) and DFS rates (18% vs. 56%, p < 0.001) than high LNR group (> 0.33, n = 43). Also, low LNR was independent prognostic factor for OS (p = 0.001) and DFS (p < 0.001) in multivariate analysis. Conclusions: TNN for node-negative rectal cancer and LNR for node-positive rectal cancer are independent prognostic factors for survival outcome in patients with locally advanced rectal cancer after preoperative radiation therapy. These factors could be considered as useful prognostic indicators irrespective of current TNM staging system.

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