Prevalence and the Risk Factors for Asymptomatic Carotid Artery Stenosis Among Type II Diabetes Mellitus Patients

Abstract Background The aim of this study was to evaluate the correlation between significant asymptomatic carotid artery stenosis (ACAS) and severity of peripheral arterial occlusive disease (PAOD) in the lower limb, and to investigate the risk factors for significant ACAS in patients with lower limb PAOD. Methods Two hundred patients with lower limb PAOD were retrospectively reviewed. Baseline data, medical history and potential risk factors were collected. Lower limb PAOD was classified as stage IIA, stage IIB, stage III and stage IV. The carotid artery stenosis was classified as significant ACAS and non-significant ACAS. Multiple logistic regression estimated odds ratio of the risk factors. Results Compared to patients with non-significant ACAS, the patients with significant ACAS were significantly older in age and had greater percentage of cigarette-smoking andalcohol beverage consumption, and higher levels of total cholesterol and fibrinogen. There was no significant difference in sex, diabetes, hypertension, coronary heart disease and triglyceride between the two groups. The prevalence rate of significant ACAS increased with the stage of lower limb PAOD and with age. Advanced age and hypercholesteremia were risk factors for significant ACAS in this cohort. The prevalence rate of stroke increased with ACAS stage. Conclusion The results suggested that the prevalence rate of significant ACAS was positively correlated with the severity of lower limb PAOD and age. Advanced age and hypercholesteremia appeared to be potential risk factors for significant ACAS in patients with lower limb PAOD.

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Multicenter Review of Preoperative Risk Factors for Endarterectomy for Asymptomatic Carotid Artery Stenosis

Stroke ◽

10.1161/01.str.29.4.750 ◽

1998 ◽

Vol 29 (4) ◽

pp. 750-753 ◽

Cited By ~ 120

Author(s):

Larry B. Goldstein ◽

Gregory P. Samsa ◽

David B. Matchar ◽

Eugene Z. Oddone

Keyword(s):

Risk Factors ◽

Carotid Artery ◽

Carotid Artery Stenosis ◽

Artery Stenosis ◽

Preoperative Risk ◽

Asymptomatic Carotid ◽

Preoperative Risk Factors ◽

Asymptomatic Carotid Artery Stenosis

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Asymptomatic Carotid Artery Stenosis among Patients with Type II Diabetes Mellitus

Journal of Bahria University Medical and Dental College ◽

10.51985/aith5490 ◽

2021 ◽

Vol 11 (01) ◽

pp. 27-30

Author(s):

Sadia Shahid ◽

Abdul Latif Khattak ◽

Karamat Hussain Shah Bukhari ◽

Raffi Uddin ◽

Raees Iqbal Khan ◽

...

Keyword(s):

Diabetes Mellitus ◽

Carotid Artery ◽

Type Ii Diabetes ◽

Leading Edge ◽

Intima Media Thickness ◽

Carotid Bifurcation ◽

Type Ii Diabetes Mellitus ◽

Type Ii ◽

Asymptomatic Carotid ◽

Media Thickness

Objectives: To assess Carotid artery intima-media thickness in patients with type II diabetes mellitus. Study design and setting: This descriptive cross-sectional study was conducted at Department of Medicine, CMH Quetta from June 2018 to May 2019. Methodology: Total 176 known type II diabetes mellitus (DM) patients were included in study. Age ranged from 30-70 years. Patients using statin drugs, chronic kidney disease and decompensated liver cirrhosis were excluded. Carotid artery ultrasonography was carried out by radiologist. Carotid artery intima-media thickness (CIMT) was achieved with a 7 MHz B-mode ultrasound system. The intima-media thickness (IMT) was demarcated as the distance between the leading edge of the luminal echo to the leading edge of the adventitia of the media. This distance was measured during the diastolic phase. This was measured 3 cm before the carotid bifurcation. Also, carotid bifurcation and internal carotid artery 2 cm distally from the carotid bifurcation was scanned. Results: Mean age was 47.86 ± 6.46 years. Most of the patients 125 (71.02%) were consisted of 30 to 50 years of age. Among them the 176 patients, 92 (52.27%) were male and 84 (47.73%) were females. Male to female ratio comprised of 1.1:1. Results further revealed that 43(24.43%) patients showed asymptomatic Carotid artery intima-media thickness. Rest there was no asymptomatic Carotid artery intima-media thickness in 133 (75.57%) patients. Conclusion: This study determined that the frequency of asymptomatic Carotid artery intima-media thickness in patients with type II diabetes mellitus is quite high.

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Oxidative injury associated with stenting of asymptomatic carotid artery stenosis

VASA ◽

10.1024/0301-1526/a000621 ◽

2017 ◽

Vol 46 (4) ◽

pp. 268-274

Author(s):

Erhan Saraçoğlu ◽

Ertan Vuruşkan ◽

Yusuf Çekici ◽

Salih Kiliç ◽

Halil Ay ◽

...

Keyword(s):

Oxidative Stress ◽

Carotid Artery ◽

Oxidative Damage ◽

Carotid Artery Stenosis ◽

Artery Stenosis ◽

Oxidative Stress Marker ◽

Asymptomatic Carotid ◽

Imaging Methods ◽

Neurological Findings ◽

Asymptomatic Carotid Artery Stenosis

Abstract. Background: After carotid artery stenting (CAS), neurological complications that cannot be explained with imaging methods may develop. In our study we aimed to show, using oxidative stress markers, isolated oxidative damage and resulting neurological findings following CAS in patients with asymptomatic carotid artery stenosis. Patients and methods: We included 131 neurologically asymptomatic patients requiring CAS. The neurological findings were evaluated using the modified Rankin Scale (mRS) prior to the procedure, one hour post-procedure, and two days after. Patients with elevated mRS scores but with or without typical hyperintense lesions observed on an MRI and with changes of oxidative stress marker levels at the time (Δtotal-thiol, Δtotal antioxidative status [TAS], and Δtotal oxidant status [TOS]) were evaluated. Results: In the neurological examination carried out one hour prior to the procedure, there were 92 patients with mRS = 0, 20 with mRS = 1, and 12 with mRS = 2. When Δtotal-thiol, ΔTAS, and ΔTOS values and the mRS were compared, it was observed that as the difference in oxidative parameters increased, clinical deterioration also increased proportionally (p = 0.001). Conclusions: We demonstrate a possible correlation between oxidative damage and neurological findings after CAS which could not be explained by routine imaging methods.

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