scholarly journals SAT-181 THE ROLES OF KETOHEXOKINASE IN RENAL SODIUM REABSORPTION AND ENDOTHELIAL FUNCTION IN MICE

2020 ◽  
Vol 5 (3) ◽  
pp. S77
Author(s):  
T. Ishimoto ◽  
T. Hayasaki ◽  
T. Doke ◽  
M. Mori-Kawabe ◽  
S. Maruyama
Keyword(s):  
Endothelial Function ◽  
Sodium Reabsorption ◽  
Renal Sodium Reabsorption

Insulin Effect on Renal Sodium Reabsorption in Adolescent Offspring of Essential Hypertensive Parents

Hypertension ◽  
1995 ◽  
Vol 26 (6) ◽  
pp. 1089-1092 ◽  
Author(s):  
B. Grunfeld ◽  
M. Gimenez ◽  
M. Balzaretti ◽  
L. Rabinovich ◽  
M. Romo ◽  
...  
Keyword(s):  
Sodium Reabsorption ◽  
Insulin Effect ◽  
Adolescent Offspring ◽  
Renal Sodium Reabsorption

Stimulation of renal sodium reabsorption by angiotensin II

1977 ◽  
Vol 232 (4) ◽  
pp. F298-F306 ◽  
Author(s):  
M. D. Johnson ◽  
R. L. Malvin
Keyword(s):  
Blood Flow ◽  
Angiotensin Ii ◽  
Flow Rate ◽  
Sodium Reabsorption ◽  
Urinary Flow ◽  
Filtration Fraction ◽  
Water Diuresis ◽  
Urinary Osmolality ◽  
Anesthetized Dogs ◽  
Renal Sodium Reabsorption

Various parameters of renal function were studied before, during, and after the infusion of physiological increments of angiotensin II directly into one renal artery of anesthetized dogs. During water diuresis and during antidiuresis induced with exogenous antidiuretic hormone (ADH), angiotensin II consistently reduced UNaV, UKV, and CPAH, and increased the filtration fraction in the infused kidney. Urinary osmolality was increased only in the presence of ADH, while during water diuresis angiotensin II had no apparent effect on urinary osmolality or flow rate. During saline diuresis, a mean increment of angiotensin II concentration of 14 pg/ml was sufficient to significantly reduce UNaV and urinary flow rate. Changes in CCr, CPAH, and filtration fraction did not correlate with changes in sodium excretion, and intracortical distribution of blood flow remained unaltered. These data support the hypothesis that normal circulating levels of angiogensin II play a direct renal role in the control of sodium, potassium, and water homeostasis, and that angiotensin II exerts a direct, stimulatory effect on tubular sodium reabsorption independent of changes in GFR, RPF, filtration fraction, or intracortical distribution of blood flow.

scholarly journals SP070FRUCTOSE METABOLISM INCREASES BLOOD PRESSURE BY THE UPREGULATION OF RENAL SODIUM REABSORPTION IN MICE

2018 ◽  
Vol 33 (suppl_1) ◽  
pp. i369-i369
Author(s):  
Takahiro Hayasaki ◽  
Takuji Ishimoto ◽  
Tomohito Doke ◽  
Miguel Lanaspa ◽  
Richard Johnson ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Sodium Reabsorption ◽  
Renal Sodium Reabsorption

Effects of Certain Inhibitors on Renal Sodium Reabsorption and ATP Specific Activity

Nephron ◽  
1968 ◽  
Vol 5 (6) ◽  
pp. 474-488 ◽  
Author(s):  
R.H. Kessler ◽  
D. Landwehr ◽  
A. Quintanilla ◽  
S.A. Weseley ◽  
W. Kaufmann ◽  
...  
Keyword(s):  
Specific Activity ◽  
Sodium Reabsorption ◽  
Renal Sodium Reabsorption

Effects of prostaglandins E1 and E2 on renal sodium reabsorption and Starling forces

1974 ◽  
Vol 226 (5) ◽  
pp. 1015-1021 ◽  
Author(s):  
JW Strandhoy ◽  
CE Ott ◽  
EG Schneider ◽  
LR Willis ◽  
NP Beck ◽  
...  
Keyword(s):  
Sodium Reabsorption ◽  
Renal Sodium Reabsorption ◽  
Prostaglandins E1 And E2

scholarly journals Deletion of the angiotensin II type 1 receptor–associated protein enhances renal sodium reabsorption and exacerbates angiotensin II–mediated hypertension

2014 ◽  
Vol 86 (3) ◽  
pp. 570-581 ◽  
Author(s):  
Masato Ohsawa ◽  
Kouichi Tamura ◽  
Hiromichi Wakui ◽  
Akinobu Maeda ◽  
Toru Dejima ◽  
...  
Keyword(s):  
Angiotensin Ii ◽  
Sodium Reabsorption ◽  
Receptor Associated Protein ◽  
Renal Sodium Reabsorption

scholarly journals Genetics of hypertension: discoveries from the bench to human populations

2014 ◽  
Vol 306 (1) ◽  
pp. F1-F11 ◽  
Author(s):  
Nora Franceschini ◽  
Thu H. Le
Keyword(s):  
Association Studies ◽  
Complex Trait ◽  
Experimental Models ◽  
Sodium Reabsorption ◽  
Human Populations ◽  
Genome Wide Association Studies ◽  
Blood Pressure Homeostasis ◽  
Genome Wide ◽  
Clinical Hypertension ◽  
Renal Sodium Reabsorption

Hypertension is a complex trait that is influenced by both heritable and environmental factors. The search for genes accounting for the susceptibility to hypertension has driven parallel efforts in human research and in research using experimental animals in controlled environmental settings. Evidence from rodent models of genetic hypertension and human Mendelian forms of hypertension and hypotension have yielded mechanistic insights into the pathways that are perturbed in blood pressure homeostasis, most of which converge at the level of renal sodium reabsorption. However, the bridging of evidence from these very diverse approaches to identify mechanisms underlying hypertension susceptibility and the translation of these findings to human populations and public health remain a challenge. Furthermore, findings from genome-wide association studies still require functional validation in experimental models. In this review, we highlight results and implications from key studies in experimental and clinical hypertension to date.

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