This paper introduces a new method of surface modification by self-assembled monolayer
(SAM) and polymer monolayer grafting. Since most of the glass surfaces lack the reactive functional
group, an activation process with 3-(trimethoxysilyl)propyl methacrylate(TPM) is used in our
experiment to generate the vinyl reactive sites on the substrate surface for further graft
polymerization. The TPM saline layer acts as the “anchor” part to link the functional part onto the
surface of substrate. The paper summarizes the surface modifications by the polymerizations of
PEGMA, AA(Acrylic acid) and NVP(Nitrogen-vinyl-2-pyrrolidone) respectively and their
applications for protein adsorption and cell adhesion through a series of measurements. In previous
research, AA and NVP had also been adopted for surface treatment and had achieved good results.
The substrate can be glass, alumina, silicon, metals or stainless steel. We choose glass as our substrate
during the experiment.
