Elevated CO2 rates in a building affect the health of the occupant. This paper deals with an experimental and numerical analysis conducted in a full-scale test room located in the Department of Mechanical Engineering at the University of Technology. The experiments and CFD were conducted for analyzing ventilation performance. It is a study on the effect of the discharge airflow rate of the ceiling type air-conditioner on ventilation performance in the lecture room with the mixing ventilation. Most obtained findings show that database and questionnaires analyzed prefer heights between 0.2 m to 1.2 m in the middle of an occupied zone and breathing zone height of between 0.75 m to 1.8 given in the literature surveyed. It is noticed the mismatch of internal conditions with thermal comfort, and indoor air quality recommended by [ASHRAE Standard 62, ANSI / ASHRAE Standard 55-2010]. CFD simulations have been carried to provide insights on the indoor air quality and comfort conditions throughout the classroom. Particle concentrations, thermal conditions, and modified ventilation system solutions are reported.