In living organisms lead is classified as potential toxic metal, and in high concentration can produce intoxication with the alteration of some vital organs, especially liver and kidney. In aquatic environment lead can be absorbed by fishes and other organisms, with different distribution in various tissues. Our aim of experiment was to verify and demonstrate the protective effect of lyophilized garlic and chlorella against bioaccumulation of lead in fishes living in aquatic environment deliberated polluted with lead. Thus, lyophilized garlic and chlorella administrated as supplements in fodder for fishes (Carassius gibelio) diminished the antagonistic effect of lead against zinc in all tested tissues: liver, kidney, heart, brain, ovary, testis, muscles myotome � epaxial, skin � with scales, gills, and intestine.