Effects of γ-aminobutyric acid (GABA) agonists and a GABA uptake inhibitor on pharmacoresistant seizure like events in organotypic hippocampal slice cultures

2009 ◽  
Vol 86 (2-3) ◽  
pp. 113-123 ◽  
Author(s):  
Abdul Wahab ◽  
Uwe Heinemann ◽  
Klaus Albus
Keyword(s):  
Hippocampal Slice ◽  
Aminobutyric Acid ◽  
Gaba Uptake ◽  
Uptake Inhibitor ◽  
Gaba Agonists ◽  
Hippocampal Slice Cultures ◽  
Gaba Uptake Inhibitor ◽  
Organotypic Hippocampal Slice Cultures

The γ-aminobutyric acid (GABA) uptake inhibitor, tiagabine, increases extracellular brain levels of GABA in awake rats

1992 ◽  
Vol 220 (2-3) ◽  
pp. 197-201 ◽  
Author(s):  
Anders Fink-Jensen ◽  
P.D. Suzdak ◽  
M.D.B. Swedberg ◽  
M.E. Judge ◽  
L. Hansen ◽  
...  
Keyword(s):  
Aminobutyric Acid ◽  
Gaba Uptake ◽  
Uptake Inhibitor ◽  
Brain Levels ◽  
Gaba Uptake Inhibitor ◽  
Awake Rats

scholarly journals A hierarchy of manganese competition and entry in organotypic hippocampal slice cultures

2021 ◽  
Author(s):  
Emily Petrus ◽  
Galit Saar ◽  
Alexia Daoust ◽  
Steve Dodd ◽  
Alan P. Koretsky
Keyword(s):  
Hippocampal Slice ◽  
Hippocampal Slice Cultures ◽  
Organotypic Hippocampal Slice Cultures

Anticonvulsant activity of the glial GABA uptake inhibitor, THAO, in chemical seizures

1989 ◽  
Vol 168 (2) ◽  
pp. 265-268 ◽  
Author(s):  
Susan F. Gonsalves ◽  
Bonnie Twitchell ◽  
Robert E. Harbaugh ◽  
Povl Krogsgaard-Larsen ◽  
Arne Schousboe
Keyword(s):  
Anticonvulsant Activity ◽  
Gaba Uptake ◽  
Uptake Inhibitor ◽  
Gaba Uptake Inhibitor

6-(4-Phenyl-benzyloxy-methyl) guvacine. Synthesis, GABA uptake inhibitor and muscarinic properties

1996 ◽  
Vol 6 (24) ◽  
pp. 3025-3028 ◽  
Author(s):  
Philippe Bisel ◽  
Jean Pierre Gies ◽  
Gilbert Schlewer ◽  
Camille G. Wermuth
Keyword(s):  
Gaba Uptake ◽  
Uptake Inhibitor ◽  
Gaba Uptake Inhibitor

Effects of the GABA uptake inhibitor tiagabine on inhibitory synaptic potentials in rat hippocampal slice cultures

1992 ◽  
Vol 67 (6) ◽  
pp. 1698-1701 ◽  
Author(s):  
S. M. Thompson ◽  
B. H. Gahwiler
Keyword(s):  
Time Constant ◽  
Decay Time ◽  
Time Course ◽  
Hippocampal Slice ◽  
Decay Time Constant ◽  
Gabab Receptors ◽  
Gaba Uptake ◽  
Whole Cell ◽  
Synaptic Potentials ◽  
Hippocampal Slice Cultures

1. The effects of the gamma-aminobutyric acid (GABA) uptake blocker tiagabine on inhibitory synaptic potentials (IPSPs) were examined with microelectrode and whole-cell recording from CA3 pyramidal cells in rat hippocampal slice cultures. 2. Tiagabine (10-25 microM) greatly prolonged the duration of monosynaptic IPSPs elicited in the presence of excitatory amino acid antagonists but had no effect on their amplitude. Part of the prolonged time course resulted from a GABAB receptor-mediated component that was not detectable under control conditions. 3. The mean decay time constant of the underlying GABAA receptor-mediated synaptic current was increased from 16 to 250 ms. Spontaneous miniature IPSPs recorded with whole-cell clamp were unaffected by tiagabine. Pentobarbital sodium, in contrast, increased the decay time constant of both evoked and spontaneous GABAA-mediated currents. 4. Tiagabine (25 microM) inhibited spontaneous and evoked epileptiform bursting induced by increasing the extracellular potassium concentration to 8 mM. 5. We conclude that GABA uptake plays a significant role in determining the time course of evoked IPSPs and also limits the likelihood that GABAB receptors are activated.

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