Protective effects of timosaponin B-II on high glucose-induced apoptosis in human umbilical vein endothelial cells

2014 ◽  
Vol 37 (1) ◽  
pp. 37-44 ◽  
Author(s):  
Changrun Guo ◽  
Lu Li ◽  
Xiaolin Yang ◽  
Zhaoqing Meng ◽  
Fei Li ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
High Glucose ◽  
Umbilical Vein ◽  
Protective Effects ◽  
Human Umbilical Vein ◽  
Induced Apoptosis ◽  
Umbilical Vein Endothelial Cells

scholarly journals Protective effects of hyperoside against H2O2-induced apoptosis in human umbilical vein endothelial cells

2016 ◽  
Vol 14 (1) ◽  
pp. 399-405 ◽  
Author(s):  
XU-LIANG HAO ◽  
YA KANG ◽  
JIAN-KUAN LI ◽  
QING-SHAN LI ◽  
EN-LI LIU ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Umbilical Vein ◽  
Protective Effects ◽  
Human Umbilical Vein ◽  
Induced Apoptosis ◽  
Umbilical Vein Endothelial Cells

Grx1 Antagonized High Glucose-Induced Apoptosis in Endothelial Cells through Inhibition of Jnk Pathway

2011 ◽  
Vol 345 ◽  
pp. 257-262
Author(s):  
Hai Tao Yu ◽  
Li Ling Yue ◽  
Chun Jing Zhang
Keyword(s):  
Endothelial Cells ◽  
High Glucose ◽  
Umbilical Vein ◽  
Annexin V ◽  
Inhibitory Effect ◽  
Expression Level ◽  
Protective Effects ◽  
Jnk Pathway ◽  
Induced Apoptosis ◽  
Umbilical Vein Endothelial Cells

To investigate the mechanism underlying the protective effects of glutaredoxin-1 (Grx1) against high glucose-induced apoptosis in umbilical vein endothelial cells. The proliferation of cells was measured by MTT assay. The cells ultra-structure were observed by TEM and the apoptotic rate was detected by the immunofluorescent of Annexin V－FITC/PI with flow cytometer. The level of p-JNK and JNK were evaluated by western bloting. Results showed that Grx1 prevented the inhibitory effect on cell viability induced by high glucose; Grxl could inhibit high glucose-induced apoptosis and restrain apoptosis rate of endothelial cell significantly. The expression level of p-JNK protein significantly increased while that of JNK protein has no insignificantly chang in cells of the high glucose group, After pretreatment with Grx1, the expression level of p-JNK protein decreased. These results demonstrated that Grx1 has protective effects against high glucose-induced apoptosis in HUVECs through inhibition of JNK pathway.

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