Protective effect of a cysteine prodrug and antioxidant, L-2-oxothiazolidine-4-carboxylate, against ethanol-induced gastric lesions in rats

2012 ◽  
Vol 64 (3) ◽  
pp. 233-237 ◽  
Author(s):  
Meshal Al Moutaery ◽  
Hannan Al Rayes ◽  
Ramaiz Al Swailam ◽  
Ibrahim Elfaki ◽  
Haseeb Ahmad Khan ◽  
...  
Keyword(s):  
Protective Effect ◽  
Gastric Lesions ◽  
Cysteine Prodrug

scholarly journals Gastroprotective effect of ethylacetate fraction of the leaves of Hannoa klaineana on aspirin and histamine-induced gastric ulcer in rats

2020 ◽  
Vol 8 (1) ◽  
pp. 70
Author(s):  
Ibrahim Abubakar ◽  
Hassan Muhammad Yankuzo ◽  
Yusha'u Shuaibu Baraya ◽  
Mu'azu Abubakar Gusau
Keyword(s):  
Protective Effect ◽  
Ph Value ◽  
Gastrointestinal Diseases ◽  
Gastric Volume ◽  
Total Acidity ◽  
Gastric Lesions ◽  
Ulcer Index ◽  
Ulcer Disease ◽  
Gastroprotective Effect ◽  
Ulcer Model

Background: Peptic ulcer disease remains endemic in our society affecting about four million people every year worldwide. Hannoa klaineana is used traditionally in the treatment of various gastrointestinal diseases including ulcer.Aim: This study aims at evaluating the gastroprotective effect of ethylacetate fraction of the leaves of Hannoa klaineana (Simaroubaceae).Methods: The gastroprotective effect of ethylacetate fraction of the Hannoa klaineana (50, 100 and 200mg/kg b.wt) was evaluated using aspirin and histamine induced ulcer models.Results: In aspirin-induced ulcer model, the ethylacetate fraction of the Hannoa klaineana demonstrated significant (p<0.001) decreased in mean ulcer index with the maximum protective effect (99.84%) at 200 mg/kg against the gastric damages. While histamine-induced ulcer model, the solvent fraction significantly (p<0.001) decreased mean ulcer index with the protective effect up to 99.83% against the gastric lesions. In both models, a significant (p<0.001) increased in pH value coupled with significant (p<0.001) decreased in gastric volume, free and total acidity in rats pre-treated with varying doses of the ethylacetate fraction was found.Conclusion: The mechanism of gastroprotective effects of ethylacetate fraction of the Hannoa klaineana could be attributed to its ability to stimulate prostaglandins secretion or possess prostaglandins like-substances or suppression of histamine-induced vasospastic effect and gastric secretion.   

scholarly journals Synthesis and Protective Effect of 1,3,5-Triazine Derivatives, Leukotriene C4 Antagonist, on HClEthanol-Induced Gastric Lesions in Rats.

1991 ◽  
Vol 39 (12) ◽  
pp. 3180-3182 ◽  
Author(s):  
Yoshihiro HASEGAWA ◽  
Toshihiko YANAGISAWA ◽  
Yuka OKUI ◽  
Toshitsugu SATO ◽  
Kunio HOSAKA ◽  
...  
Keyword(s):  
Protective Effect ◽  
Leukotriene C4 ◽  
Gastric Lesions ◽  
Triazine Derivatives

Role of peripheral capsaicin-sensitive neurons and CGRP in central vagally mediated gastroprotective effect of TRH

1994 ◽  
Vol 266 (5) ◽  
pp. R1610-R1614
Author(s):  
K. Kato ◽  
H. Yang ◽  
Y. Tache
Keyword(s):  
Monoclonal Antibody ◽  
Protective Effect ◽  
Sensory Neurons ◽  
Gastric Lesions ◽  
Conscious Rats ◽  
Calcitonin Gene ◽  
Efferent Pathways ◽  
Afferent Terminals ◽  
Cgrp Antagonist

We investigated in conscious rats the role of capsaicin-sensitive neurons and alpha-calcitonin gene-related peptide (CGRP), the form preferentially expressed in capsaicin sensory neurons, in mediating intracisternal thyrotropin-releasing hormone (TRH) analogue-induced vagal muscarinic gastroprotection against ethanol lesions. The TRH analogue RX-77368 (1.5 ng ic) reduced by 78 and 66% gastric hemorrhagic lesions induced by intragastric intubation of 60 and 80% ethanol, respectively. alpha-CGRP (1 nmol/kg iv) inhibited by 88% gastric lesions induced by 60% ethanol, and this peptide action was blocked by the CGRP antagonist, CGRP-(8-37) (128 nmol/kg iv). The protective effect of RX-77368 against 60% ethanol was completely abolished by the CGRP monoclonal antibody 4901 (4.8 mg/kg iv), CGRP-(8-37) (128 nmol/kg iv), and capsaicin pretreatment (125 mg/kg). Gastric lesions induced by 60% ethanol were not altered by the CGRP antagonist or antibody alone but were enhanced by capsaicin pretreatment. These results suggest that the gastroprotection induced by intracisternal TRH analogue involves an interaction between central vagal efferent pathways and splanchnic sensory afferent terminals containing CGRP.

scholarly journals Protective effect of Artemisia campestris extract against aspirin-induced gastric lesions and oxidative stress in rat

RSC Advances ◽  
2014 ◽  
Vol 4 (91) ◽  
pp. 49831-49841 ◽  
Author(s):  
Hichem Sebai ◽  
Mohamed-Amine Jabri ◽  
Abdelaziz Souli ◽  
Karim Hosni ◽  
Slimen Selmi ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Protective Effect ◽  
Gastric Lesions ◽  
Artemisia Campestris ◽  
And Oxidative Stress

ChemInform Abstract: Synthesis and Protective Effect of 1,3,5-Triazine Derivatives, Leukotriene C4 Antagonist, on HCl×Ethanol-Induced Gastric Lesions in Rats.

ChemInform ◽  
2010 ◽  
Vol 23 (42) ◽  
pp. no-no
Author(s):  
Y. HASEGAWA ◽  
T. YANAGISAWA ◽  
Y. OKUI ◽  
T. SATO ◽  
K. HOSAKA ◽  
...  
Keyword(s):  
Protective Effect ◽  
Leukotriene C4 ◽  
Gastric Lesions ◽  
Triazine Derivatives
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