P.0278 Structural brain abnormalities associated with cognitive impairments in bipolar disorder

2021 ◽  
Vol 53 ◽  
pp. S201
Author(s):  
J. Macoveanu ◽  
K.O. Freeman ◽  
H.L. Kjærstad ◽  
G.M. Knudsen ◽  
L.V. Kessing ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Cognitive Impairments ◽  
Brain Abnormalities ◽  
Structural Brain

Structural brain abnormalities associated with cognitive impairments in bipolar disorder

2021 ◽  
Author(s):  
Julian Macoveanu ◽  
Katherine Olivia Freeman ◽  
Hanne Lie Kjærstad ◽  
Gitte Moos Knudsen ◽  
Lars Vedel Kessing ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Cognitive Impairments ◽  
Brain Abnormalities ◽  
Structural Brain

scholarly journals Structural brain abnormalities in bipolar disorder: what meta-analyses tell us

2010 ◽  
Vol 196 (3) ◽  
pp. 245-246 ◽  
Author(s):  
Antonio Vita ◽  
Luca De Peri ◽  
Emilio Sacchetti
Keyword(s):  
Bipolar Disorder ◽  
Brain Abnormalities ◽  
Meta Analyses ◽  
Structural Brain

Structural brain abnormalities in patients with type I bipolar disorder and suicidal behavior

2017 ◽  
Vol 265 ◽  
pp. 9-17 ◽  
Author(s):  
Dante G.G. Duarte ◽  
Maila de Castro L. Neves ◽  
Maicon R. Albuquerque ◽  
Gustavo Turecki ◽  
Yang Ding ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Suicidal Behavior ◽  
Type I ◽  
Brain Abnormalities ◽  
Structural Brain

Assessment of the neuronal underpinnings of cognitive impairment in bipolar disorder with a picture encoding paradigm and methodological lessons learnt

2021 ◽  
pp. 026988112110085
Author(s):  
JZ Petersen ◽  
J Macoveanu ◽  
HL Kjærstad ◽  
GM Knudsen ◽  
LV Kessing ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Cognitive Impairment ◽  
Neuronal Activity ◽  
Cognitive Impairments ◽  
Hierarchical Cluster ◽  
Small Region ◽  
Middle Temporal Gyrus ◽  
Recall Accuracy ◽  
Fmri Study

Background: Mood disorders are often associated with persistent cognitive impairments. However, pro-cognitive treatments are essentially lacking. This is partially because of poor insight into the neurocircuitry abnormalities underlying these deficits and their change with illness progression. Aims: This functional magnetic resonance imaging (fMRI) study investigates the neuronal underpinnings of cognitive impairments and neuronal change after mood episodes in remitted patients with bipolar disorder (BD) using a hippocampus-based picture encoding paradigm. Methods: Remitted patients with BD ( n=153) and healthy controls ( n=52) were assessed with neuropsychological tests and underwent fMRI while performing a strategic picture encoding task. A subgroup of patients ( n=43) were rescanned after 16 months. We conducted data-driven hierarchical cluster analysis of patients’ neuropsychological data and compared encoding-related neuronal activity between the resulting neurocognitive subgroups. For patients with follow-up data, effects of mood episodes were assessed by comparing encoding-related neuronal activity change in BD patients with and without episode(s). Results: Two neurocognitive subgroups were revealed: 91 patients displayed cognitive impairments while 62 patients were cognitively normal. No neuronal activity differences were observed between neurocognitive subgroups within the dorsal cognitive control network or hippocampus. However, exploratory whole-brain analysis revealed lower activity within a small region of middle temporal gyrus in impaired patients, which significantly correlated with poorer neuropsychological performance. No changes were observed in encoding-related neuronal activity or picture recall accuracy with the occurrence of mood episode(s) during the follow-up period. Conclusion: Memory encoding fMRI paradigms may not capture the neuronal underpinnings of cognitive impairment or effects of mood episodes.

Structural brain abnormalities in the early phase of schizophrenia

2008 ◽  
Vol 23 ◽  
pp. S119-S120
Author(s):  
R. Herold ◽  
A. Feldmann ◽  
T. Tenyi ◽  
F. Kover ◽  
S. Fekete
Keyword(s):  
Early Phase ◽  
Brain Abnormalities ◽  
Structural Brain

Akt-mTOR hypoactivity in bipolar disorder gives rise to cognitive impairments associated with altered neuronal structure and function

Neuron ◽  
2021 ◽  
Author(s):  
Amanda M. Vanderplow ◽  
Andrew L. Eagle ◽  
Bailey A. Kermath ◽  
Kathryn J. Bjornson ◽  
Alfred J. Robison ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Cognitive Impairments ◽  
Structure And Function ◽  
Neuronal Structure ◽  
And Function
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