Assessment of the neuronal underpinnings of cognitive impairment in bipolar disorder with a picture encoding paradigm and methodological lessons learnt

2021 ◽  
pp. 026988112110085
Author(s):  
JZ Petersen ◽  
J Macoveanu ◽  
HL Kjærstad ◽  
GM Knudsen ◽  
LV Kessing ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Cognitive Impairment ◽  
Neuronal Activity ◽  
Cognitive Impairments ◽  
Hierarchical Cluster ◽  
Small Region ◽  
Middle Temporal Gyrus ◽  
Recall Accuracy ◽  
Fmri Study

Background: Mood disorders are often associated with persistent cognitive impairments. However, pro-cognitive treatments are essentially lacking. This is partially because of poor insight into the neurocircuitry abnormalities underlying these deficits and their change with illness progression. Aims: This functional magnetic resonance imaging (fMRI) study investigates the neuronal underpinnings of cognitive impairments and neuronal change after mood episodes in remitted patients with bipolar disorder (BD) using a hippocampus-based picture encoding paradigm. Methods: Remitted patients with BD ( n=153) and healthy controls ( n=52) were assessed with neuropsychological tests and underwent fMRI while performing a strategic picture encoding task. A subgroup of patients ( n=43) were rescanned after 16 months. We conducted data-driven hierarchical cluster analysis of patients’ neuropsychological data and compared encoding-related neuronal activity between the resulting neurocognitive subgroups. For patients with follow-up data, effects of mood episodes were assessed by comparing encoding-related neuronal activity change in BD patients with and without episode(s). Results: Two neurocognitive subgroups were revealed: 91 patients displayed cognitive impairments while 62 patients were cognitively normal. No neuronal activity differences were observed between neurocognitive subgroups within the dorsal cognitive control network or hippocampus. However, exploratory whole-brain analysis revealed lower activity within a small region of middle temporal gyrus in impaired patients, which significantly correlated with poorer neuropsychological performance. No changes were observed in encoding-related neuronal activity or picture recall accuracy with the occurrence of mood episode(s) during the follow-up period. Conclusion: Memory encoding fMRI paradigms may not capture the neuronal underpinnings of cognitive impairment or effects of mood episodes.

Cognitive Impairments and Associated Factors After Ruptured Anterior Communicating Artery Aneurysm Treatment in Low-Grade Patients <60 Years: A Multicenter Retrospective Study

2020 ◽  
Author(s):  
Ning Ma ◽  
Xin Feng ◽  
Zhongxue Wu ◽  
Daming Wang ◽  
Aihua Liu
Keyword(s):  
Regression Analysis ◽  
Cognitive Impairment ◽  
Cox Regression ◽  
Cognitive Impairments ◽  
Young Patients ◽  
Endovascular Coiling ◽  
Anterior Communicating Artery ◽  
Cox Regression Analysis ◽  
Microsurgical Clipping

Abstract Background Aneurysmal subarachnoid hemorrhage (SAH) is a kind of destructive cerebrovascular disease which could affect people's cognition, even the life expectancy. People with SAH are considered in a fatal situation, especially in the young population. This study aimed to investigate cognitive impairment and related factors in young patients with ruptured anterior communicating artery (ACoA) aneurysms.Methods We conducted a multicentre retrospective follow-up study at three hospitals in China. The young patients (18-50 years) who underwent ruptured ACoA aneurysm treatment by microsurgical clipping or endovascular coiling at three academic institutions in China from January 2015 to November 2017 were recruited. Patient cognition and life quality were assessed by using modified Telephone Interview for Cognitive Status (TICS-m), the modified Rankin Scale (mRS), and the instrumental activities of daily living (IADL) scale 2. Multiple cox-regression analysis was used to identify variables independently associated with cognitive impairment.Results Of the total of 59 patients, 54 (91.5%) achieved good clinical outcomes (mRS score 0-2) and 51 (86.4%) had excellent quality of life (IADL score 8). Ten (16.9%) patients showed cognitive impairments (TICS-m<27). The multivariate COX regression analysis showed that mRS scores of 3-5 at discharge, female sex, and aneurysm size <5 mm was independently associated with cognitive impairment. TICS-m scores at the latest follow-up were similar after open surgery and coiling. Conclusion In this relatively young sample that excluded patients with very poor-grade SAH or serious complications, microsurgical clipping led to better clinical outcomes than endovascular coiling, while cognitive outcomes were similar across treatment modalities. These results are not completely consistent with previous studies, and should therefore be considered in the clinical practice as well as further investigated in larger patient samples.

scholarly journals Modulation of brain response to emotional conflict as a function of current mood in bipolar disorder: Preliminary findings from a follow-up state-based fMRI study

2014 ◽  
Vol 223 (2) ◽  
pp. 84-93 ◽  
Author(s):  
Gwladys Rey ◽  
Martin Desseilles ◽  
Sophie Favre ◽  
Alexandre Dayer ◽  
Camille Piguet ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Brain Response ◽  
Emotional Conflict ◽  
Fmri Study ◽  
Current Mood

Remission of positive symptoms according to the “remission in Schizophrenia Working Group” criteria: A longitudinal study of cognitive functioning

2013 ◽  
Vol 28 (5) ◽  
pp. 282-287 ◽  
Author(s):  
Y. Braw ◽  
R. Sitman ◽  
M. Cohen ◽  
U. Berger ◽  
S. Lev-Ran ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Longitudinal Study ◽  
Cognitive Functioning ◽  
Working Group ◽  
Longitudinal Research ◽  
Cognitive Impairments ◽  
Positive Symptoms ◽  
Longitudinal Research Design ◽  
Symptomatic Remission

AbstractSchizophrenia patients in positive symptomatic remission (PSR; n = 39) were assessed using a longitudinal research design. The patients were found to exhibit widespread cognitive impairments that were stable over the three-year follow-up period. The findings support a generalized and stable cognitive impairment profile among schizophrenia patients in partial symptomatic remission.

Five-year follow-up of cognitive impairment in older adults with bipolar disorder

2016 ◽  
Vol 18 (2) ◽  
pp. 148-154 ◽  
Author(s):  
Sigfried NTM Schouws ◽  
Hannie C Comijs ◽  
Annemieke Dols ◽  
Aartjan TF Beekman ◽  
Max L Stek
Keyword(s):  
Older Adults ◽  
Bipolar Disorder ◽  
Cognitive Impairment

Abstract P244: Comorbidities and Physical and Cognitive Impairments in Elderly Heart Failure Patients: Impact on Total Mortality: The Cardiovascular Health Study (CHS)

Circulation ◽  
2012 ◽  
Vol 125 (suppl_10) ◽  
Author(s):  
Khalil Murad ◽  
David C Goff ◽  
Timothy M Morgan ◽  
Gregory L Burke ◽  
Dalane W Kitzman
Keyword(s):  
Heart Failure ◽  
Cognitive Impairment ◽  
Elderly Patients ◽  
Mortality Risk ◽  
Daily Living ◽  
Cognitive Impairments ◽  
Total Mortality ◽  
Cardiovascular Health Study ◽  
Activity Of Daily Living

Background: Comorbidities and physical and cognitive impairments are common in patients with heart failure (HF) and often associated with greater mortality. However, the prevalence of these conditions and their associated mortality risk in elderly patients with incident HF is unknown. Method: We examined the prevalence of 9 comorbidities and 4 measures of physical and cognitive impairments in 558 participants from CHS (age 79.2 ± 6.3, 52% men) with incident HF diagnosed between 1990 and 2002. Participants were followed prospectively until mid 2008 (an average follow up time of 4.7 years) to determine the associated mortality risk. Results: The burden of comorbidities was high; 60% of participants had ≥ 3 comorbidities, and only 2.5% had none. Impairment in ≥ 1 activity of daily living (ADL) and ≥ 1 instrumental activity of daily living (IADL) was present in 22.5% and 43.7% of participants, respectively. Significant cognitive impairment (modified mini-mental state exam (3MSE) score < 80) was present in 17% of participants. During follow up, 504 participants died, with 1-year and 5-year survival rates of 0.81 and 0.44 respectively. In a multivariable-adjusted model, the following were significantly associated with greater total mortality (hazard ratio: 95% confidence interval): comorbidities including diabetes mellitus (1.64: 1.33–2.03), chronic kidney disease (moderate (1.32: 1.07–1.62); severe (3.00: 1.82–4.95)), cerebrovascular disease (1.53: 1.22–1.92), and depression (1.44: 1.09–1.90); Physical impairment (1 ADL impaired (1.30: 1.04–1.63); ≥ 2 IADL impaired (1.49: 1.07–2.04)); and cognitive impairment (3MSE score < 80 (1.33: 1.02–1.73)). Conclusion: Elderly patients with incident HF have high burdens of comorbidities and physical and cognitive impairments that significantly contribute to their high mortality rates.

Associations between cognition in parents with schizophrenia or bipolar disorder and their 7-year old high-risk offspring

2017 ◽  
Vol 41 (S1) ◽  
pp. s813-s813
Author(s):  
A.N. Greve ◽  
J.R.M. Jepsen ◽  
V. Bliksted ◽  
E.L. Rasmussen ◽  
D. Gantriis ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Cognitive Impairment ◽  
Social Cognition ◽  
High Risk ◽  
Cognitive Functioning ◽  
Verbal Memory ◽  
Cognitive Impairments ◽  
Risk And Resilience ◽  
Birth Cohorts ◽  
Competing Interest

IntroductionNeurocognitive and social cognitive impairments are central characteristics of schizophrenia and, to a lesser extent, of bipolar disorder. Birth cohorts and familial high risk studies have described cognitive impairments in subjects before onset of diagnosis as well as in children with increased genetic risk for development of the disorders.ObjectivesTo our knowledge, this is the first study to investigate the correlations between neurocogntion and social cognition in parents and offspring simultaneously and with the same methodology. We will divide the parents into subgroups (cognitive impairment and good cognitive functioning) and use these subgroups to describe correlations with their offspring. Identifying associations between parents and offspring can add important clues to risk factors for schizophrenia and bipolar disorder and, on the long-term, help the development of more effective and potentially preventive treatments.MethodsThis study is part of the Danish high risk and resilience study–VIA7. The VIA7 cohort consists of 522 children age 7 with zero, 1 or 2 parents diagnosed with schizophrenia or bipolar disorder and both of their biological parents. We assessed neurocognition and social cognition with a comprehensive test battery including: intelligence (RIST), executive functions (WAIS-IV, D-KEFS, CANTAB), verbal memory (TOMAL2), attention, emotion recognition, decision making and response control (CANTAB), theory of mind (animated triangles) and social perception (TASIT). Parental subgroups were based on the 95% CI of the controls (cognitive impairment < 95%CI and good cognitive functioning > 95% CI).ResultsData analysis is ongoing and results will be presented at the conference.Disclosure of interestThe authors have not supplied their declaration of competing interest.

Small World Index in Default Mode Network Predicts Progression from Mild Cognitive Impairment to Dementia

2020 ◽  
Vol 30 (02) ◽  
pp. 2050004 ◽  
Author(s):  
Francesca Miraglia ◽  
Fabrizio Vecchio ◽  
Camillo Marra ◽  
Davide Quaranta ◽  
Francesca Alù ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Default Mode Network ◽  
Resting State ◽  
Cognitive Impairments ◽  
Small World ◽  
Default Mode ◽  
Delta Band ◽  
Eeg Functional Connectivity

Aim of this study was to explore the EEG functional connectivity in amnesic mild cognitive impairments (MCI) subjects with multidomain impairment in order to characterize the Default Mode Network (DMN) in converted MCI (cMCI), which converted to Alzheimer’s disease (AD), compared to stable MCI (sMCI) subjects. A total of 59 MCI subjects were recruited and divided -after appropriate follow-up- into cMCI or sMCI. They were further divided in MCI with linguistic domain (LD) impairment and in MCI with executive domain (ED) impairment. Small World (SW) index was measured as index of balance between integration and segregation brain processes. SW, computed restricting to nodes of DMN regions for all frequency bands, evaluated how they differ between MCI subgroups assessed through clinical and neuropsychological four-years follow-up. In addition, SW evaluated how this pattern differs between MCI with LD and MCI with ED. Results showed that SW index significantly decreased in gamma band in cMCI compared to sMCI. In cMCI with LD impairment, the SW index significantly decreased in delta band, while in cMCI with ED impairment the SW index decreased in delta and gamma bands and increased in alpha1 band. We propose that the DMN functional alterations in cognitive impairment could reflect an abnormal flow of brain information processing during resting state possibly associated to a status of pre-dementia.

scholarly journals Are Empirically-Derived Subtypes of Mild Cognitive Impairment Consistent with Conventional Subtypes?

2013 ◽  
Vol 19 (6) ◽  
pp. 635-645 ◽  
Author(s):  
Lindsay R. Clark ◽  
Lisa Delano-Wood ◽  
David J. Libon ◽  
Carrie R. McDonald ◽  
Daniel A. Nation ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Diagnostic Errors ◽  
Hierarchical Cluster ◽  
Diagnostic Methods ◽  
Cognitive Domain ◽  
Normal Limits ◽  
Prodromal Alzheimer’S Disease ◽  
Advanced Stages

AbstractGiven the importance of identifying dementia prodromes for future treatment efforts, we examined two methods of diagnosing mild cognitive impairment (MCI) and determined whether empirically-derived MCI subtypes of these diagnostic methods were consistent with one another as well as with conventional MCI subtypes (i.e., amnestic, non-amnestic, single-domain, multi-domain). Participants were diagnosed with MCI using either conventional Petersen/Winblad criteria (n = 134; >1.5 SDs below normal on one test within a cognitive domain) or comprehensive neuropsychological criteria developed by Jak et al. (2009) (n = 80; >1 SD below normal on two tests within a domain), and the resulting samples were examined via hierarchical cluster and discriminant function analyses. Results showed that neuropsychological profiles varied depending on the criteria used to define MCI. Both criteria revealed an Amnestic subtype, consistent with prodromal Alzheimer's disease (AD), and a Mixed subtype that may capture individuals in advanced stages of MCI. The comprehensive criteria uniquely yielded Dysexecutive and Visuospatial subtypes, whereas the conventional criteria produced a subtype that performed within normal limits, suggesting its susceptibility to false positive diagnostic errors. Whether these empirically-derived MCI subtypes correspond to dissociable neuropathologic substrates and represent reliable prodromes of dementia will require additional follow-up. (JINS, 2013, 19, 1–11)

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