Main-chain degradable, pH-responsive and covalently cross-linked nanoparticles via a one-step RAFT-based radical ring-opening terpolymerization

2020 ◽  
Vol 122 ◽  
pp. 109391 ◽  
Author(s):  
Alexander W. Jackson ◽  
Lohitha Rao Chennamaneni ◽  
Praveen Thoniyot
Keyword(s):  
Ring Opening ◽  
Main Chain ◽  
Ph Responsive ◽  
Radical Ring ◽  
One Step

Main-chain degradable star polymers comprised of pH-responsive hyperbranched cores and thermoresponsive polyethylene glycol-based coronas

2018 ◽  
Vol 9 (39) ◽  
pp. 4824-4839 ◽  
Author(s):  
Ulrike Wais ◽  
Lohitha Rao Chennamaneni ◽  
Praveen Thoniyot ◽  
Haifei Zhang ◽  
Alexander W. Jackson
Keyword(s):  
Polyethylene Glycol ◽  
Ring Opening ◽  
Main Chain ◽  
Star Polymers ◽  
Hyperbranched Polymers ◽  
Ph Responsive ◽  
Radical Ring ◽  
Ketene Acetal

Dual stimuliresponsive main-chain degradable star hyperbranched polymers have been synthesized via cyclic ketene acetal radical ring-opening and RAFT-based methacrylate copolymerization.

scholarly journals Novel monomers in radical ring-opening polymerisation for biodegradable and pH responsive nanoparticles

2019 ◽  
Vol 10 (39) ◽  
pp. 5285-5288 ◽  
Author(s):  
Jenny Folini ◽  
Chao-Hung Huang ◽  
James C. Anderson ◽  
Wolfgang P. Meier ◽  
Jens Gaitzsch
Keyword(s):  
Ring Opening ◽  
Ph Sensitive ◽  
Ph Responsive ◽  
Radical Ring ◽  
Cyclic Ketene Acetals ◽  
Ketene Acetals

We report the first amine-bearing cyclic ketene acetals (CKAs) for radical ring-opening polymerisation (RROP). The resulting polyesters and their corresponding nanoparticles were biodegradable and showed the desired pH sensitive behaviour.

scholarly journals Influence of cyclodextrin on the solubility of a classically prepared 2-vinylcyclopropane macromonomer in aqueous solution

2012 ◽  
Vol 8 ◽  
pp. 1528-1535 ◽  
Author(s):  
Helmut Ritter ◽  
Jia Cheng ◽  
Monir Tabatabai
Keyword(s):  
Aqueous Solution ◽  
Carboxylic Acid ◽  
Graft Copolymer ◽  
Ring Opening ◽  
Main Chain ◽  
Double Bonds ◽  
Radical Ring ◽  
Unsaturated Polymer ◽  
End Group ◽  
Clouding Point

A macromonomer 5 consisting of a polymerizable vinylcyclopropane end group and a poly(N-isopropylacrylamide) (poly(NiPAAm)) chain was obtained from amidation of 1-ethoxycarbonyl-2-vinylcyclopropane-1-carboxylic acid (4) with an amino-terminated poly(NiPAAm) 3 as an example. This macromonomer 5 showed an LCST effect after complexation of the vinyl end group with ß-cyclodextrin in water. Via radical ring-opening copolymerization of 5 and NiPAAm a graft copolymer 8 with a clouding point of 32 °C was synthesized. The branched unsaturated polymer was treated with ozone to cleave the double bonds of the main chain.

scholarly journals Truly Random Degradable Vinyl Copolymers via Photocontrolled Radical Ring-Opening Cascade Copolymerization

2021 ◽  
Author(s):  
Wenqi Wang ◽  
Zefeng Zhou ◽  
Xuanting Tang ◽  
Stephanie Moran ◽  
Jing Jin ◽  
...  
Keyword(s):  
Sulfur Dioxide ◽  
Ring Opening ◽  
Main Chain ◽  
Radical Ring ◽  
Polymer Backbone ◽  
Vinyl Polymers ◽  
Powerful Approach ◽  
Chain Composition ◽  
Promising Solution

Degradable vinyl polymers by radical ring-opening polymerization have become a promising solution to the challenges caused by the widespread use of non-degradable vinyl plastics. However, achieving even distribution of labile functional groups in the backbone of degradable vinyl polymers remains challenging. Herein, we report a photocatalytic approach to truly random degradable vinyl copolymers with tunable main-chain composition via radical ring-opening cascade copolymerization (rROCCP). The rROCCP of the macrocyclic allylic sulfone and acrylates or acrylamides mediated by visible light at ambient temperature achieved near-unity reactivity ratios of both comonomers over the entire range of the comonomer compositions and afforded truly random vinyl copolymers with degradable units evenly distributed in the polymer backbone. Experimental and computational evidence revealed an unusual reversible inhibition of chain propagation by in situ generated sulfur dioxide, which was successfully overcome by reducing the solubility of sulfur dioxide in the reaction mixture. This study provided a powerful approach to truly random degradable vinyl copolymers with tunable main-chain labile functionalities and comparable thermal and mechanical properties to traditional non-degradable vinyl polymers.

Biodegradable phosphorylcholine copolymer for cardiovascular stent coating

2020 ◽  
Vol 8 (24) ◽  
pp. 5361-5368 ◽  
Author(s):  
Jun Liu ◽  
Jing Wang ◽  
Yun-fan Xue ◽  
Ting-ting Chen ◽  
Dan-ni Huang ◽  
...  
Keyword(s):  
Ring Opening ◽  
Ring Opening Polymerization ◽  
Promising Material ◽  
Radical Ring ◽  
Biodegradable Stent ◽  
Cardiovascular Stent ◽  
One Step ◽  
Stent Coating

A biodegradable phosphorylcholine-based copolymer synthesized via one-step radical ring-opening polymerization may be a promising material for biodegradable stent coating.

TiCp2Cl-Catalyzed Living Radical and Ring Opening Polymerizations Initiated from Epoxides and Aldehydes in the Synthesis of Linear, Graft and Branched Polymers

2004 ◽  
Vol 856 ◽  
Author(s):  
Alexandru D. Asandei ◽  
Isaac W. Moran ◽  
Gobinda Saha ◽  
Yanhui Chen
Keyword(s):  
Electron Transfer ◽  
Ring Opening ◽  
Glycidyl Methacrylate ◽  
Ring Opening Polymerization ◽  
Branched Polymers ◽  
Single Electron Transfer ◽  
Radical Ring ◽  
Polymer Architectures ◽  
Complex Polymer

ABSTRACTTi(III)Cp2Cl-catalyzed radical ring opening (RRO) of epoxides or single electron transfer (SET) reduction of aldehydes generates Ti alkoxides and carbon centered radicals which add to styrene, initiating a radical polymerization. This polymerization is mediate in a living fashion by the reversible termination of growing chains with the TiCp2Cl metalloradical. In addition, polymers or monomers containing pendant epoxide groups (glycidyl methacrylate) can be used as substrates for radical grafting or branching reactions by self condensing vinyl polymerization. In addition, Ti alkoxides generated in situ by both epoxide RRO and aldehyde SET initiate the living ring opening polymerization of ε-caprolactone. Thus, new initiators and catalysts are introduced for the synthesis of complex polymer architectures.

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