alternating copolymers
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Molecules ◽  
2022 ◽  
Vol 27 (2) ◽  
pp. 466
Vamshi K. Chidara ◽  
Yves Gnanou ◽  
Xiaoshuang Feng

The anionic ring-opening copolymerization (ROCOP) of epoxides, namely of ethylene oxide (EO), with anhydrides (AH) generally produces strictly alternating copolymers. With triethylborane (TEB)-assisted ROCOP of EO with AH, statistical copolymers of high molar mass including ether and ester units could be obtained. In the presence of TEB, the reactivity ratio of EO (rEO), which is normally equal to 0 in its absence, could be progressively raised to values lower than 1 or higher than 1. Conditions were even found to obtain rEO equal or close to 1. Samples of P(EO-co-ester) with minimal compositional drift could be synthesized; upon basic degradation of their ester linkages, these samples afforded poly(ethylene oxide) (PEO) diol samples of narrow molar mass distribution. In other cases where rEO were lower or higher than 1, the PEO diol samples eventually isolated after degradation exhibited a broader distribution of molar masses because of the compositional drift of initial P(EO-co-ester) samples.

2021 ◽  
pp. 105550
Seyyed Emad Hooshmand ◽  
Arefeh Ebadati ◽  
Elaheh Sadat Hosseini ◽  
Amir Hossein Vahabi ◽  
Mojgan Oshaghi ◽  

2021 ◽  
Adrian H. Kopf ◽  
Odette Lijding ◽  
Barend O. W. Elenbaas ◽  
Martijn C. Koorengevel ◽  
Justyna M. Dobruchowska ◽  

Amphipathic copolymers such as poly(styrene-maleic acid) (SMA) are promising tools for the facile extraction of membrane proteins (MPs) into native nanodiscs. Here, we designed and synthesized a library of well-defined alternating copolymers of SMA analogues in order to elucidate polymer properties that are important for MP solubilization and stability. MP extraction efficiency was determined using KcsA from E.coli membranes and general solubilization efficiency was investigated via turbidimetry experiments on membranes of E.coli, yeast mitochondria and synthetic lipids. Remarkably, halogenation of SMA copolymers dramatically improved solubilization efficiency in all systems, while substituents on the copolymer backbone improved resistance to Ca2+. Relevant polymer properties were found to include hydrophobic balance, size and positioning of substituents, rigidity and electronic effects. The library thus contributes to the rational design of copolymers for the study of MPs.

2021 ◽  
pp. 2100501
Sagar Bag ◽  
Soumyadeep Ghosh ◽  
Soumya Paul ◽  
Md Ezaz Hasan Khan ◽  
Priyadarsi De

2021 ◽  
pp. 1174-1179
Zhenghui Liu ◽  
Yuan Yao ◽  
Xinfeng Tao ◽  
Jie Wei ◽  
Shaoliang Lin

Samantha Saxer ◽  
Omer Erdogan ◽  
Cédric Paniagua ◽  
Alain Chavanieu ◽  
Xavier Garric ◽  

Cansu Zeytun Karaman ◽  
Seza Göker ◽  
Ümmügülsüm Şahin ◽  
Serife O. Hacioglu ◽  
Sultan Taşkaya Aslan ◽  

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