Étude des anomalies morphométriques et de perfusion dans la dépression chronique et résistante

2013 ◽  
Vol 28 (S2) ◽  
pp. 32-32
Author(s):  
J.-M. Batail ◽  
J.-C. Ferré ◽  
J.-Y. Gauvrit ◽  
D. Drapier ◽  
B. Millet
Keyword(s):  
Spin Labeling ◽  
Non Invasive ◽  
Débit Sanguin

La dépression est une pathologie invalidante et récurrente. En effet, après un premier épisode dépressif caractérisé, le risque de rechute est estimé à 50 %. À l’heure actuelle, les processus physiopathologiques impliqués dans cette pathologie restent encore mal compris [2]. L’Arterial Spin Labeling (ASL) est une technique d’imagerie de perfusion innovante, non invasive, permettant une quantification du débit sanguin cérébral [1]. Elle a été utilisée dans l’étude de la perfusion cérébrale dans le trouble dépressif récurrent et résistant [3,4] avec des résultats divergents. Aucune étude n’a encore combiné des données morphométriques et de perfusion (ASL). L’objectif de ce travail est d’étudier les anomalies de perfusion et morphométriques impliquées chez des patients souffrant d’un état dépressif caractérisé et stratifiés en deux populations, les patients résistants et répondeurs aux thérapeutiques usuelles. Une hyper-perfusion de l’amygdale droite (p = 0,02) et de l’hippocampe droit (p = 0,02) chez les patients résistants a été décrite. Il a également été retrouvée une atrophie de régions corticales telles que le cortex orbito-frontal (p < 0,001), le cortex cingulaire antérieur (p = 0,002) chez les patients déprimés, ainsi qu’une hypertrophie des hippocampes droit et gauche (p = 0,004, p < 0,001) des patients résistants en comparaison des répondeurs. Notre étude a pu mettre en exergue que la combinaison des informations à la fois morphométriques et de perfusion permettrait d’améliorer la stratification des patients déprimés et notamment en ce qui concerne la notion de résistance thérapeutique.

Challenges for Non-Invasive Brain Perfusion Quantification Using Arterial Spin Labeling

2011 ◽  
Vol 24 (1) ◽  
pp. 77-83 ◽  
Author(s):  
I. Sousa ◽  
N. Santos ◽  
J. Sanches ◽  
P. Vilela ◽  
P. Figueiredo
Keyword(s):  
Arterial Spin Labeling ◽  
Brain Perfusion ◽  
Spin Labeling ◽  
Non Invasive ◽  
Perfusion Quantification

scholarly journals Measurement of Blood Flow in Arteriovenous Malformations before and after Embolization Using Arterial Spin Labeling

2012 ◽  
Vol 18 (1) ◽  
pp. 42-48 ◽  
Author(s):  
L. Suazo ◽  
B. Foerster ◽  
R. Fermin ◽  
H. Speckter ◽  
C. Vilchez ◽  
...  
Keyword(s):  
Arterial Spin Labeling ◽  
Spin Labeling ◽  
Conventional Angiography ◽  
Vein Of Galen Aneurysm ◽  
Non Invasive ◽  
Shunt Occlusion ◽  
Before And After ◽  
Invasive Method ◽  
Magnetic Resonance Imaging Mri ◽  
Partially Occluded

The assessment of shunt reduction after an embolization of an arteriovenous malformation (AVM) or fistula (AVF) from conventional angiography is often difficult and may be subjective. Here we present a completely non-invasive method using magnetic resonance imaging (MRI) to measure shunt reduction. Using pulsed arterial spin labeling (PASL), we determined the relative amount of signal attributed to the shunt over 1.75 s and 6 different slices covering the lesion. This amount of signal from the shunt was related to the total signal from all slices and measured before and after embolization. The method showed a fair agreement between the PASL results and the judgement from conventional angiography. In the case of a total or subtotal shunt occlusion, PASL showed a shunt reduction between 69% and 92%, whereas in minimal shunt reduction as judged by conventional angiography, the ASL result was −6% (indicating slightly increased flow) to 35% in a partially occluded vein of Galen aneurysm. The PASL method proved to be fairly reproducible (up to 2% deviation between three measurements without interventions). On conclusion, PASL is able to reliably measure the amount of shunt reduction achieved by embolization of AVMs and AVFs.

scholarly journals The Potential Utility of Arterial Spin Labeling in Detecting and Localizing Posterior Circulation Occlusions in Every Day Practice: A Clinical Report of Selected Cases

2020 ◽  
Vol 10 ◽  
pp. 78
Author(s):  
Vivek Yedavalli ◽  
Elizabeth Tong
Keyword(s):  
Arterial Spin Labeling ◽  
Cerebral Perfusion ◽  
Spin Labeling ◽  
Posterior Circulation ◽  
Clinical Report ◽  
Stroke Subtype ◽  
Everyday Clinical Practice ◽  
Anterior Circulation ◽  
Non Invasive ◽  
Invasive Method

Arterial spin labeling (ASL) is a non-contrast, non-invasive method used for the evaluation of cerebral perfusion, which is now increasingly utilized in everyday clinical practice. As a marker of cerebral blood flow at the capillary level, it has particular utility in stroke assessment. One rarer stroke subtype with non-specific symptomatology that can lead to significant morbidity is the posterior circulation (PC) infarct. As with the more common anterior circulation infarcts, ASL has shown benefit in PC infarcts as well, but has not been extensively explored in the literature nor been directly compared to bolus perfusion techniques. This clinical report of selected cases shows the utility of ASL in localization and detection of PC infarcts both in conjunction with and in the absence of bolus perfusion.

scholarly journals Arterial spin labeling perfusion-weighted MRI for long-term follow-up of a cerebral arteriovenous malformation after stereotactic radiosurgery

2014 ◽  
Vol 3 (1) ◽  
pp. 204798161351016 ◽  
Author(s):  
Kazuhiro Shimizu ◽  
Nobuyuki Kosaka ◽  
Tatsuya Yamamoto ◽  
Hiroki Shioura ◽  
Toshiaki Kodera ◽  
...  
Keyword(s):  
Stereotactic Radiosurgery ◽  
Arterial Spin Labeling ◽  
Spin Labeling ◽  
High Signal ◽  
Non Invasive ◽  
Signal Abnormality ◽  
Complete Obliteration ◽  
Long Term Follow Up

We present a longitudinal series of arterial spin-labeling magnetic resonance imaging (ASL-MRI) in a patient with cerebral arteriovenous malformations (AVMs) treated by stereotactic radiosurgery (SRS). Pretreatment ASL-MRI showed high signal intensity in both the nidus and draining veins, and the latter signal abnormality gradually moved proximally by 14 months after SRS. At 24 months, the signal abnormalities finally disappeared, indicating complete obliteration of the nidus. The hemodynamic changes in the AVM were clearly visualized in the longitudinal ASL-MRI series, thus this non-invasive MR method may be useful not only for detecting AVMs but also for assessment of their response after SRS.

scholarly journals Comparison of non-invasive MRI measurements of cerebral blood flow in a large multisite cohort

2016 ◽  
Vol 36 (7) ◽  
pp. 1244-1256 ◽  
Author(s):  
Sudipto Dolui ◽  
Ze Wang ◽  
Danny JJ Wang ◽  
Raghav Mattay ◽  
Mack Finkel ◽  
...  
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Arterial Spin Labeling ◽  
Phase Contrast ◽  
Spin Labeling ◽  
Flow Measurements ◽  
Entire Cohort ◽  
Non Invasive ◽  
Global Cerebral Blood Flow ◽  
Continuous Arterial Spin Labeling

Arterial spin labeling and phase contrast magnetic resonance imaging provide independent non-invasive methods for measuring cerebral blood flow. We compared global cerebral blood flow measurements obtained using pseudo-continuous arterial spin labeling and phase contrast in 436 middle-aged subjects acquired at two sites in the NHLBI CARDIA multisite study. Cerebral blood flow measured by phase contrast (CBFPC: 55.76 ± 12.05 ml/100 g/min) was systematically higher ( p < 0.001) and more variable than cerebral blood flow measured by pseudo-continuous arterial spin labeling (CBFPCASL: 47.70 ± 9.75). The correlation between global cerebral blood flow values obtained from the two modalities was 0.59 ( p < 0.001), explaining less than half of the observed variance in cerebral blood flow estimates. Well-established correlations of global cerebral blood flow with age and sex were similarly observed in both CBFPCASL and CBFPC. CBFPC also demonstrated statistically significant site differences, whereas no such differences were observed in CBFPCASL. No consistent velocity-dependent effects on pseudo-continuous arterial spin labeling were observed, suggesting that pseudo-continuous labeling efficiency does not vary substantially across typical adult carotid and vertebral velocities, as has previously been suggested. Conclusions: Although CBFPCASL and CBFPC values show substantial similarity across the entire cohort, these data do not support calibration of CBFPCASL using CBFPC in individual subjects. The wide-ranging cerebral blood flow values obtained by both methods suggest that cerebral blood flow values are highly variable in the general population.

scholarly journals Non-invasive assessment of placental perfusion in vivo using arterial spin labeling (ASL) MRI: A preclinical study in rats

Placenta ◽  
2019 ◽  
Vol 77 ◽  
pp. 39-45 ◽  
Author(s):  
Benjamin Deloison ◽  
Laurent J. Salomon ◽  
Thibaud Quibel ◽  
Gihad E. Chalouhi ◽  
Marianne Alison ◽  
...  
Keyword(s):  
Arterial Spin Labeling ◽  
Spin Labeling ◽  
Preclinical Study ◽  
Placental Perfusion ◽  
Non Invasive
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