Dimensional and discrete variations on the psychosis continuum in a Dutch crowd-sourcing population sample

2017 ◽  
Vol 42 ◽  
pp. 55-62 ◽  
Author(s):  
J.T.W. Wigman ◽  
K.J. Wardenaar ◽  
R.B.K. Wanders ◽  
S.H. Booij ◽  
B.F. Jeronimus ◽  
...  

AbstractBackgroundMild psychotic experiences are common in the general population. Although transient and benign in most cases, these experiences are predictive of later mental health problems for a significant minority. The goal of the present study was to perform examinations of the dimensional and discrete variations in individuals’ reporting of subclinical positive and negative psychotic experiences in a unique Dutch internet-based sample from the general population.MethodsPositive and negative subclinical psychotic experiences were measured with the Community Assessment of Psychic Experiences in 2870 individuals. First, the prevalence of these experiences and their associations with demographics, affect, psychopathology and quality of life were investigated. Next, latent class analysis was used to identify data-driven subgroups with different symptom patterns, which were subsequently compared on aforementioned variables.ResultsSubclinical psychotic experiences were commonly reported. Both positive and negative psychotic experiences were associated with younger age, more negative affect, anxiety and depression as well as less positive affect and poorer quality of life. Seven latent classes (‘Low psychotic experiences’, ‘Lethargic’, ‘Blunted’, ‘Distressed’, ‘Paranormal’, ‘Distressed_grandiose’ and ‘Distressed/positive psychotic experiences’) were identified that demonstrated both dimensional differences in the number/severity of psychotic experiences and discrete differences in the patterns of reported experiences.ConclusionSubclinical psychotic experiences show both dimensional severity variations and discrete symptom-pattern variations across individuals. To understand and capture all interindividual variations in subclinical psychotic experiences, their number, nature and context (co-occurrence patterns) should be considered at the same time. Only some psychotic experiences may lay on a true psychopathological psychosis continuum.

2010 ◽  
Vol 120 (1-3) ◽  
pp. 126-132 ◽  
Author(s):  
Mascha C. ten Doesschate ◽  
Maarten W.J. Koeter ◽  
Claudi L.H. Bockting ◽  
Aart H. Schene

2011 ◽  
Vol 20 (7) ◽  
pp. 1123-1129 ◽  
Author(s):  
Luciane N. Cruz ◽  
Carisi A. Polanczyk ◽  
Suzi A. Camey ◽  
Juliana F. Hoffmann ◽  
Marcelo P. Fleck

2013 ◽  
Vol 13 (1) ◽  
Author(s):  
Jonathan Mond ◽  
Deborah Mitchison ◽  
Janet Latner ◽  
Phillipa Hay ◽  
Cathy Owen ◽  
...  

2008 ◽  
Vol 10 (5) ◽  
pp. 625-634 ◽  
Author(s):  
Luis Gutirrez-Rojas ◽  
Manuel Gurpegui ◽  
Jos L Ayuso-Mateos ◽  
Jos A Gutirrez-Ariza ◽  
Miguel Ruiz-Veguilla ◽  
...  

2020 ◽  
Vol 4 (1) ◽  
Author(s):  
Kim Rand ◽  
Espen Ajo Arnevik ◽  
Espen Walderhaug

Abstract Purpose There is a need to assess the quality of treatment for Substance Use Disorder (SUD), and document SUD patients’ health-related quality of life (HRQoL). The study aims to describe Norwegian SUD patients’ HRQoL as measured by EQ-5D, compared to a general population sample, and discuss the potential usefulness of the EQ-5D to monitor HRQoL for SUD patients. Methods One hundred seventy eight SUD patients (66.3% male) were administered the EQ-5D-3L at treatment start. Patients and general population samples were compared in terms of reported EQ-5D-3L health states, problems by dimension, UK index values, and EQ VAS scores. We investigated specific drug dependence, mental health disorders, sex, age, and education as predictors of EQ-5D-3L values and EQ VAS scores. Anxiety/depression dimension scores were compared to Hopkins symptom Checklist (HSCL-25) scores. Results 91.6% of the patient sample reported problems on the EQ-5D-3L, with 29.8% reporting extreme problem, compared to 39.8% and 3.0% in the general population sample. Mean index (EQ VAS) score among SUD patients was .59 (59.9) compared to .90 (84.1) in the general population. Regression analyses identified phobic anxiety and cocaine dependence as statistically significant predictors of higher EQ-5D-3L index scores. Conclusion SUD patients report substantially reduced HRQoL, as measured using the EQ-5D-3L. The most frequently reported problems were for the anxiety/depression, pain/discomfort, and usual activities dimensions. The EQ-5D may be a useful and practical instrument for monitoring HRQoL in SUD patients.


2008 ◽  
Vol 102 (3) ◽  
pp. 399-406 ◽  
Author(s):  
Marianne Voll-Aanerud ◽  
Tomas M.L. Eagan ◽  
Tore Wentzel-Larsen ◽  
Amund Gulsvik ◽  
Per S. Bakke

Sleep Science ◽  
2019 ◽  
Vol 12 (2) ◽  
Author(s):  
Camila Hirotsu ◽  
Cristina Frange ◽  
Patricia H Hirata ◽  
Renata C Cremaschi ◽  
Fernando M Coelho ◽  
...  

2009 ◽  
Vol 160 (1) ◽  
pp. 17-24 ◽  
Author(s):  
Joern Moock ◽  
Christin Albrecht ◽  
Nele Friedrich ◽  
Henry Völzke ◽  
Matthias Nauck ◽  
...  

ObjectiveTo analyse 12-month response to GH treatment in a single-country cohort of hypopituitary adult patients with GH deficiency (GHD) in regards to health-related quality of life (HRQoL) and insulin-like growth factor-1 (IGF-1) compared with values from general population sample. Moreover, association between the response in HRQoL and the IGF-1 values in patients and in the background population was investigated.DesignHRQoL was assessed by quality of life assessment of GH deficiency in adults (QoL-AGHDA) in 651 patients retrieved from the German KIMS (Pfizer International Metabolic Database) before and after 12 months of GH replacement and in a sample drawn from a cross-sectional study in Germany (n=2734). IGF-1 was measured in KIMS patients and in the population-based study with the same assay technique.ResultsIn KIMS patients, mean QoL-AGHDA scores before GH replacement were 9.2±6.8 (8.7±6.8) in women (men) and in the general population sample 4.5±5.3 (4.3±5.0) in women (men). Mean differences in QoL-AGHDA scores were statistically significant for all age categories (P<0.05). The mean IGF-1 SDS of KIMS patients before GH replacement was −1.1±1.4 (−0.8±1.4) in women (men). After GH replacement, a significant increase of IGF-1 concentration and a significant decrease of QoL-AGHDA scores near to age- and gender-specific population-based values were observed.ConclusionsThis study confirms an improvement in HRQoL and an increase of IGF-1 SDS in GH-replaced adults, which approximated the values of general population. However, there was no association between IGF-1 values and HRQoL assessment as one of the important treatment outcomes.


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