scholarly journals Health-related quality of life and IGF-1 in GH-deficient adult patients on GH replacement therapy: analysis of the German KIMS data and the Study of Health in Pomerania

2009 ◽  
Vol 160 (1) ◽  
pp. 17-24 ◽  
Author(s):  
Joern Moock ◽  
Christin Albrecht ◽  
Nele Friedrich ◽  
Henry Völzke ◽  
Matthias Nauck ◽  
...  
Keyword(s):  
Quality Of Life ◽  
General Population ◽  
Gh Deficiency ◽  
Population Sample ◽  
Population Based ◽  
General Population Sample ◽  
Gh Replacement ◽  
Related Quality ◽  
Health Related

ObjectiveTo analyse 12-month response to GH treatment in a single-country cohort of hypopituitary adult patients with GH deficiency (GHD) in regards to health-related quality of life (HRQoL) and insulin-like growth factor-1 (IGF-1) compared with values from general population sample. Moreover, association between the response in HRQoL and the IGF-1 values in patients and in the background population was investigated.DesignHRQoL was assessed by quality of life assessment of GH deficiency in adults (QoL-AGHDA) in 651 patients retrieved from the German KIMS (Pfizer International Metabolic Database) before and after 12 months of GH replacement and in a sample drawn from a cross-sectional study in Germany (n=2734). IGF-1 was measured in KIMS patients and in the population-based study with the same assay technique.ResultsIn KIMS patients, mean QoL-AGHDA scores before GH replacement were 9.2±6.8 (8.7±6.8) in women (men) and in the general population sample 4.5±5.3 (4.3±5.0) in women (men). Mean differences in QoL-AGHDA scores were statistically significant for all age categories (P<0.05). The mean IGF-1 SDS of KIMS patients before GH replacement was −1.1±1.4 (−0.8±1.4) in women (men). After GH replacement, a significant increase of IGF-1 concentration and a significant decrease of QoL-AGHDA scores near to age- and gender-specific population-based values were observed.ConclusionsThis study confirms an improvement in HRQoL and an increase of IGF-1 SDS in GH-replaced adults, which approximated the values of general population. However, there was no association between IGF-1 values and HRQoL assessment as one of the important treatment outcomes.

Health related quality of life in recurrent depression: A comparison with a general population sample

2010 ◽  
Vol 120 (1-3) ◽  
pp. 126-132 ◽  
Author(s):  
Mascha C. ten Doesschate ◽  
Maarten W.J. Koeter ◽  
Claudi L.H. Bockting ◽  
Aart H. Schene
Keyword(s):  
Quality Of Life ◽  
General Population ◽  
Population Sample ◽  
General Population Sample ◽  
Health Related Quality ◽  
Recurrent Depression ◽  
Related Quality ◽  
Health Related

scholarly journals Respiratory symptoms, COPD severity, and health related quality of life in a general population sample

2008 ◽  
Vol 102 (3) ◽  
pp. 399-406 ◽  
Author(s):  
Marianne Voll-Aanerud ◽  
Tomas M.L. Eagan ◽  
Tore Wentzel-Larsen ◽  
Amund Gulsvik ◽  
Per S. Bakke
Keyword(s):  
Quality Of Life ◽  
General Population ◽  
Respiratory Symptoms ◽  
Population Sample ◽  
General Population Sample ◽  
Health Related Quality ◽  
Related Quality ◽  
Health Related

scholarly journals Health-related quality of life in Brazil: normative data for the SF-36 in a general population sample in the south of the country

2013 ◽  
Vol 18 (7) ◽  
pp. 1911-1921 ◽  
Author(s):  
Luciane Nascimento Cruz ◽  
Marcelo Pio de Almeida Fleck ◽  
Michele Rosana Oliveira ◽  
Suzi Alves Camey ◽  
Juliana Feliciati Hoffmann ◽  
...  
Keyword(s):  
Quality Of Life ◽  
General Population ◽  
Normative Data ◽  
Population Sample ◽  
General Population Sample ◽  
Health Related Quality ◽  
Sf 36 ◽  
Related Quality ◽  
Health Related

The objective of this study was to provide normative SF-36 scores in a general population sample in Brazil and to describe differences in mean scores according to socio-demographic characteristics. The SF-36 questionnaire was distributed to a randomly selected sample of the general population of Porto Alegre in the State of Rio Grande do Sul. The response rate was 68% and 755 subjects were included (38% male, 62% female). Lower health status was revealed among females in the 30 to 44 year age bracket, from the lower income class, with less education and self-reported chronic medical conditions. The results and percentiles of scores of the SF-36 are reported as normative data for the general population. The SF-36 was an acceptable and practical instrument for measuring health-related quality of life in a sample of Brazilians. The results of this study can be useful for researchers using the SF-36 questionnaire in other groups to compare the scores with normative data. The SF-36 may prove a valuable tool for discovering vulnerable groups in epidemiological studies due to the ability to discriminate between different population subgroups.

Health-related Quality of Life in Preschool Children with Wheezing and Dyspnea: Preliminary Results from a Random General Population Sample

2005 ◽  
Vol 14 (8) ◽  
pp. 1931-1936 ◽  
Author(s):  
Ashna D. Mohangoo ◽  
Marie-Louise Essink-Bot ◽  
Elizabeth F. Juniper ◽  
Henriëtte A. Moll ◽  
Harry J. de Koning ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Preschool Children ◽  
General Population ◽  
Population Sample ◽  
General Population Sample ◽  
Health Related Quality ◽  
Preliminary Results ◽  
Related Quality ◽  
Health Related

scholarly journals Health-Related Quality of Life in Patients with Philadelphia-Negative Myeloproliferative Neoplasms: A Nationwide Population-Based Survey in Denmark

Cancers ◽  
2020 ◽  
Vol 12 (12) ◽  
pp. 3565
Author(s):  
Nana Brochmann ◽  
Esben Meulengracht Flachs ◽  
Anne Illemann Christensen ◽  
Marie Bak ◽  
Christen Lykkegaard Andersen ◽  
...  
Keyword(s):  
Quality Of Life ◽  
General Population ◽  
Myeloproliferative Neoplasms ◽  
Population Based ◽  
Public Hospitals ◽  
Health Related Quality ◽  
Symptom Profile ◽  
Related Quality ◽  
Health Related

Previous studies have clarified that many patients with Philadelphia-negative myeloproliferative neoplasms (MPNs) have burdensome symptom profiles and accordingly impaired functioning and quality of life (QoL). In Denmark, all MPN patients are affiliated with public hospitals and because of a healthcare system financed by taxpayers these patients do not have any financial costs related to the hematological disease. Diagnoses are recorded for all patients in hospitals, and diagnosis codes are communicated to the National Patient Register (NPR). Owing to this, it was possible to contribute to the elucidation of Philadelphia-negative MPN patients’ health-related quality of life (HRQoL), by conducting a nationwide, population-based, cross-sectional HRQoL survey of these patients with cost-free access to the best available, suitable medical treatment. The survey contained validated questionnaires covering functioning, symptom burden, symptom profile, QoL, and additional questions on lifestyle. Information on comorbid diagnoses was obtained from the NPR. The participants’ HRQoL was compared to the general population. Moreover, differences in HRQoL across essential thrombocythemia, polycythemia vera, myelofibrosis, and unclassifiable MPN participants were investigated, adjusted for age, sex, comorbidity, and lifestyle. To the best of our knowledge this is the first survey of HRQoL in patients with unclassifiable MPN. A total of 2228 Philadelphia-negative MPN patients participated. The participants reported their HRQoL to be inferior to the general population, but the difference was minor. The differences in HRQoL across groups of participants with different MPN subtypes were subtle. Fatigue and sexual problems were prevalent and burdensome. Overall, participants reported a slightly healthier lifestyle compared to the general population.

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