Role of Transurethral Resection of the Prostate and Biopsy of the Peripheral Zone in the Same Session after Repeated Negative Biopsies in the Diagnosis of Prostate Cancer

AbstractIntroduction: Prostate cancer is the second most diagnosed cancer in men, after lung cancer. The gold standard procedure in prostate cancer (PCa) diagnosis is the ultrasound guided prostate biopsy. Transurethral resection of the prostate (TURP) used in solving the bladder outlet obstruction, can have a role in detection of PCa. The aim of this retrospective study is to examine the role of transurethral resection of the prostate in the diagnosis and therapy of prostate cancer.Materials and methods: At the Urology Clinic of Targu Mures we performed a total of 474 TURP over a two year period (2011-2013). The patients had a mean age of 71.857 years, and the indications were PCa with bladder outlet obstruction or bladder outlet obstruction with unknown causes but some with suspicion of PCa.Results: In case of 474 patients with TURP performed for bladder outlet obstruction, the histopathology findings were the following: 61 cases with newly diagnosed PCa, some in spite of normal PSA values, 23 cases with already hormone treated prostate cancer, while in 50 cases TURP was preceded by prostate biopsy (in 8 cases with increased PSA and several negative biopsies, we could confirm PCa of the peripheral zone of the prostate).Conclusion: TURP remains the elective surgical therapy of the bladder outlet obstruction, caused by BPH and even prostate cancer. Obtaining a greater volume of prostate tissue can help in the detection of prostate cancer in its early stages, especially in the transitional zone.

Download Full-text

The role of magnetic resonance imaging in targeting prostate cancer in patients with previous negative biopsies and elevated prostate-specific antigen levels

BJU International ◽

10.1111/j.1464-410x.2008.08205.x ◽

2009 ◽

Vol 103 (6) ◽

pp. 730-733 ◽

Cited By ~ 77

Author(s):

Nathan Lawrentschuk ◽

Neil Fleshner

Keyword(s):

Magnetic Resonance Imaging ◽

Prostate Cancer ◽

Magnetic Resonance ◽

Prostate Specific Antigen ◽

Specific Antigen ◽

Resonance Imaging ◽

Negative Biopsies

Download Full-text

S79 THE ROLE OF TRANSURETHRAL RESECTION OF PROSTATE IN (TURP) DETECTING PROSTATE CANCER IN PATIENTS WITH PREVIOUSLY NEGATIVE BIOPSY, ELEVATED PSA LEVELS AND POSITIVE LOWER URINARY TRACT SYMPTOMS

European Urology Supplements ◽

10.1016/s1569-9056(13)60273-0 ◽

2012 ◽

Vol 11 (4) ◽

pp. 153

Author(s):

Zafarghandi R. Mahdavi ◽

K. Aghamohammadpour ◽

A. Ghoreifi

Keyword(s):

Prostate Cancer ◽

Urinary Tract ◽

Lower Urinary Tract Symptoms ◽

Transurethral Resection ◽

Lower Urinary Tract ◽

Transurethral Resection Of Prostate ◽

Negative Biopsy ◽

Urinary Tract Symptoms ◽

Lower Urinary

Download Full-text

Testosterone, prolactin, and oncogenic regulation of the prostate gland. A new concept: Testosterone-independent malignancy is the development of prolactin-dependent malignancy!

Oncology Reviews ◽

10.4081/oncol.2018.356 ◽

2018 ◽

Cited By ~ 1

Author(s):

Leslie C. Costello ◽

Renty B. Franklin

Keyword(s):

Prostate Cancer ◽

Epithelial Cells ◽

Signaling Pathways ◽

Prostate Gland ◽

Peripheral Zone ◽

Metabolic Function ◽

Androgen Ablation ◽

Prolactin Signaling ◽

Maintenance Metabolism

Hormone-independent malignancy is a major issue of morbidity and deaths that confronts prostate cancer. Despite decades of research, the oncogenic and hormonal implications in the development and progression of prostate malignancy remain mostly speculative. This is largely due to the absence and/or lack of consideration by contemporary clinicians and biomedical investigators regarding the established implications of the co-regulation of testosterone and prolactin in the development, maintenance, metabolism and functions of the prostate gland. Especially relevant is the major metabolic function of production of high levels of citrate by the peripheral zone acinar epithelial cells. Citrate production, along with growth and proliferation by these cells, is regulated by co-existing testosterone and prolactin signaling pathways; and by the oncogenic down-regulation of ZIP1 transporter/zinc/citrate in the development of malignancy. These relationships had not been considered in the issues of hormonedependent malignancy. This review provides the relevant background that has established the dual role of testosterone and prolactin regulation of the prostate gland; which is essential to address the implications in the oncogenic development and progression of hormone-dependent malignancy. The oncogenic factor along with testosterone-dependent and prolactin-dependent relationships leads to the plausible concept that androgen ablation for the treatment of testosterone-dependent malignancy results in the development of prolactin-dependent malignancy; which is testosterone-independent malignancy. Consequently, both testosterone ablation and prolactin ablation are required to prevent and/or abort terminal hormonedependent prostate cancer.

Download Full-text